(chloromethyl)trimethylsilane

• ChemBase编号: 87753
• 分子式: C4H11ClSi
• 平均质量: 122.66864
• 单一同位素质量: 122.03185456
• SMILES: [Si](C)(C)(CCl)C
• Canonical SMILES: ClC[Si](C)(C)C
• InChI: InChI=1S/C4H11ClSi/c1-6(2,3)4-5/h4H2,1-3H3
• InChIKey: OOCUOKHIVGWCTJ-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: (chloromethyl)trimethylsilane
• IUPAC传统名: (chloromethyl)trimethylsilane
• 别名: 三甲基氯甲基硅烷; (氯甲基)三甲基硅烷; CHLOROMETHYLTRIMETHYLSILANE; Silane CMM3; (Chloromethyl)trimethylsilane; (Trimethylsilyl)methyl chloride; (Chloromethyl)trimethylsilane

登记号

• CAS号: 2344-80-1
• EC号: 219-058-5
• MDL号: MFCD00000878
• Beilstein号: 906705
• PubChem SID: 24850936; 162074793; 24852326; 24855086
• PubChem CID: 75361

理论计算性质

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): 3.057
• LogD (pH = 7.4): 3.057
• Log P: 3.057
• 摩尔折射率: 26.6836 cm^3
• 极化性: 12.8536415 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 1
• 里宾斯基五规则: true

分子性质

理化性质

• 沸点: 97-98°C; 98-99 °C(lit.); 98-99°C
• 闪点: -2°C(28°F); 24.8 °F; -4 °C; -4°C
• 密度: 0.879; 0.879 g/mL at 25 °C(lit.); 0.88 g/mL at 20 °C; 0.886
• 折射率: 1.4180; n20/D 1.418(lit.)
• 蒸汽压: ~25 mmHg ( 20 °C)

安全信息

• 保存注意事项: Irritant/Highly Flammable/Keep Cold; Moisture Sensitive
• 欧盟危险性物质标志: 易燃性(Flammable) (F); 刺激性(Irritant) (Xi)
• 联合国危险货物编号: 1993; UN1993
• 德国WGK号: 3
• 联合国危险货物等级: 3
• 联合国危险货物包装类别(PG): 2; II
• 危险公开号: 11-36/37/38
• 安全公开号: 16-26-36; 9-16-23-26-33-37
• TSCA收录: 是
• GHS危险品标识: GHS02; GHS07
• GHS警示词: Danger
• GHS危险声明: H224-H315-H319-H335; H225-H315-H319-H335
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A; P210-P261-P305 + P351 + P338
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 1993 3/PG 2

产品相关信息

• 纯度: ≥98.0% (GC); 97%; 98%
• 级别: produced by Wacker; purum
• 线性分子式: (CH3)3SiCH2Cl

详细说明

MP Biomedicals - 05205827

MP Biomedicals Rare Chemical collection

Sigma Aldrich - 205354

包装
25, 4×25, 100 mL in Sure/Seal™

Sigma Aldrich - 18146

Other Notes
根据要求提供批量采购价
包装
1 kg in glass bottle
250 g in glass bottle

Sigma Aldrich - 25300

Other Notes
用于酮类和醛类通过α,β-环氧硅烷进行皮特森成烯反应和同素化反应的试剂，综述1,2；用于合成烯丙基硅烷3

参考文献

• For a review of the chemistry of chloromethyltrimethylsilane, see: Synthesis, 717 (1985).
• Treatment with s-BuLi at -78^o gives ɑ-lithio-ɑ-chloromethyltrimethylsilane which reacts with aldehydes and ketones to give ɑ?-epoxy silanes, readily hydrolyzed to homologated aldehydes: Tetrahedron, 39, 867 (1983):
  
• Metallation gives useful precursors of various organosilicon compounds. For use of the Grignard in the olefination of ketones, see: J. Org. Chem., 39, 3264 (1974); 52, 281 (1987). For Ni-catalyzed reaction of the Grignard with allylic dithioacetals, see: J. Org. Chem., 53, 5582 (1988); Org. Synth. Coll., 9, 727 (1998); for an example with reaction scheme, see trans-Cinnamaldehyde, A14689.