1-[4-(prop-2-enoyl)piperazin-1-yl]prop-2-en-1-one

• ChemBase编号: 78399
• 分子式: C10H14N2O2
• 平均质量: 194.23036
• 单一同位素质量: 194.1055277
• SMILES: N1(CCN(C(=O)C=C)CC1)C(=O)C=C
• Canonical SMILES: C=CC(=O)N1CCN(CC1)C(=O)C=C
• InChI: InChI=1S/C10H14N2O2/c1-3-9(13)11-5-7-12(8-6-11)10(14)4-2/h3-4H,1-2,5-8H2
• InChIKey: YERHJBPPDGHCRJ-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 1-[4-(prop-2-enoyl)piperazin-1-yl]prop-2-en-1-one
• IUPAC传统名: 1-[4-(prop-2-enoyl)piperazin-1-yl]prop-2-en-1-one
• 别名: 1,4-二丙烯酰哌嗪; 1,4-DIACRYLOYLPIPERAZINE; 1,4-Di(acryloyl)piperazine; N,N′-Bis(acryloyl)piperazine; BAP; PDA; Piperazine diacrylamide; 1,4-Bis(acryloyl)piperazine; 1,4-(Diacryloyl)piperazine; 1,1'-(1,4-Piperazinediyl)bis-2-propen-1-one; 1,4-Bis(1-oxo-2-propenyl)piperazine; 1,4-Bis(acryloyl)piperazine; N,N'-Bisacryloylpiperazine; NSC 133364; NSC 49404; PIP; 1,4-Diacrylylpiperazine; Diacroyl piperazine; 1,4-Diacryloylpiperazine

登记号

• CAS号: 6342-17-2
• EC号: 000-000-0
• MDL号: MFCD00077661
• Beilstein号: 745431
• PubChem SID: 24848678; 162043168; 24893477; 24878601
• PubChem CID: 193422

理论计算性质

• 质子受体: 2
• 质子供体: 0
• LogD (pH = 5.5): 0.0036626533
• LogD (pH = 7.4): 0.0036637203
• Log P: 0.003663734
• 摩尔折射率: 53.876 cm^3
• 极化性: 20.36739 Å^3
• 极化表面积: 40.62 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

分子性质

理化性质

• 熔点: 91.5-93.5 °C(lit.); 91.5-93.5°C; 91-95°C

安全信息

• 保存注意事项: Irritant/Hygroscopic
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 3
• 危险公开号: 36/37/38
• 安全公开号: 26-36; 26-37
• TSCA收录: 否
• GHS危险品标识: GHS07
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• GHS警示性声明: P261-P305 + P351 + P338; P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves; Eyeshields, Gloves
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥99%; ≥99.0% (TLC); 97%
• 适用性: suitable for electrophoresis
• 杂质: ≤0.05% free acrylic acid
• 痕量阳离子: Zn: ≤5 mg/kg
• 痕量阴离子: sulfate (SO42-): ≤50 mg/kg
• 产品线: BioReagent
• Empirical Formula (Hill Notation): C10H14N2O2

详细说明

MP Biomedicals - 04809240

1,4-Diacryloylpiperazine is a unique polyacrylamide gel crosslinker. Used in place of Bis (N,N'-methylene-bis-acrylamide), 1,4-Diacryloylpiperazine provides increased gel strength, improved electrophoretic separation of proteins, and less background during silver staining.
Purity: >99%
mp 94-96° C
White powder
Heavy metals (as Pb): <10ppm

MP Biomedicals - 04809237

1,4-Diacryloylpiperazine is a unique polyacrylamide gel crosslinker. Used in place of Bis (N,N'-methylene-bis-acrylamide), 1,4-Diacryloylpiperazine provides increased gel strength, improved electrophoretic separation of proteins, and less background during silver staining.
Purity: >99%
mp 94-96° C
White powder
Heavy metals (as Pb): <10ppm

MP Biomedicals - 04809239

1,4-Diacryloylpiperazine is a unique polyacrylamide gel crosslinker. Used in place of Bis (N,N'-methylene-bis-acrylamide), 1,4-Diacryloylpiperazine provides increased gel strength, improved electrophoretic separation of proteins, and less background during silver staining.
Purity: >99%
mp 94-96° C
White powder
Heavy metals (as Pb): <10ppm

Sigma Aldrich - D1538

Application
PDA is used as a cross-linker for polyacrylamide gels to reduce background on silver-stained gels. PDA has also been shown to increase resolution and increase gel strength.
包装
5, 10 g in poly bottle

Sigma Aldrich - 14470

Other Notes
Used as a vinylating agent for graft-copolymerization of different enzymes to cellulose, dextran, or starch1; New crosslinking agent for polyacrylamide gels with improved protein separation and detection by silver staining2; Increased resolution in 2D-protein electrophoresis3.

Sigma Aldrich - 542350

Application
Cross-linking monomer for development of polyacrylamide gels.

Toronto Research Chemicals - D416000

Used as a crosslinker in polyacrylamide gels. PIP provides polyacrylamide gels with increased physical strength and improved separation and detection of proteins.

参考文献

• Hochstrasser, A., Patchornik, A., Merrill, C., Analytical Biochemistry , 173 : 412 (1988).
• Hochstrasser, A., Patchornik, A., Merrill, C., Analytical Biochemistry , 173 : 412 (1988).
• Hochstrasser, A., Patchornik, A., Merrill, C., Analytical Biochemistry , 173 : 412 (1988).
• Cross-linker in polyacrylamide gels.