chloro({[chlorobis(propan-2-yl)silyl]oxy})bis(propan-2-yl)silane

• ChemBase编号: 76130
• 分子式: C12H28Cl2OSi2
• 平均质量: 315.42712
• 单一同位素质量: 314.10557394
• SMILES: O([Si](C(C)C)(C(C)C)Cl)[Si](Cl)(C(C)C)C(C)C
• Canonical SMILES: CC([Si](C(C)C)(O[Si](C(C)C)(C(C)C)Cl)Cl)C
• InChI: InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
• InChIKey: DDYAZDRFUVZBMM-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: chloro({[chlorobis(propan-2-yl)silyl]oxy})bis(propan-2-yl)silane
• IUPAC传统名: chloro[(chlorodiisopropylsilyl)oxy]diisopropylsilane
• 别名: 1,3-二氯-1,1,3,3-四异丙基二硅氧烷; TIPDSiCl2; 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane; 1,3-Dichloro-1,1,3,3-tetrakis(prop-2-yl)disiloxane; 1,3-Dichloro-1,1,3,3-tetrakis(isopropyl)disiloxane; 1,3-DICHLORO-1,1,3,3-TETRA-ISOPROPYL-1,3-DISILOXANE

登记号

• CAS号: 69304-37-6
• EC号: 000-000-0
• MDL号: MFCD00009655
• Beilstein号: 1934216
• PubChem SID: 162041045; 24860447; 24862477; 24862491
• PubChem CID: 172404

理论计算性质

• 质子受体: 1
• 质子供体: 0
• LogD (pH = 5.5): 4.9202
• LogD (pH = 7.4): 4.9202
• Log P: 4.9202
• 摩尔折射率: 73.4112 cm^3
• 极化性: 33.049164 Å^3
• 极化表面积: 9.23 Å^2
• 可自由旋转的化学键: 6
• 里宾斯基五规则: true

分子性质

理化性质

• 沸点: 69-70°C/0.5mm; 70 °C/0.5 mmHg(lit.); 70°C/0.5mm
• 闪点: >110°C(230°F); 110 °C; 110°C; 113 °C; 230 °F; 235.4 °F
• 密度: 0.986; 0.986 g/mL at 25 °C(lit.); 1.0 g/ml
• 折射率: 1.4540; n20/D 1.454(lit.); n20/D 1.455

安全信息

• 保存注意事项: Corrosive/Moisture Sensitive/Keep Cold/Store under Argon; Moisture Sensitive
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• 联合国危险货物编号: 3265; UN1760
• 德国WGK号: 3
• 联合国危险货物等级: 8
• 联合国危险货物包装类别(PG): 2; II
• 危险公开号: 34
• 安全公开号: 20-26-36/37/39-45; 26-27-28-36/37/39-45
• TSCA收录: 否
• GHS危险品标识: GHS05
• GHS警示词: Danger
• GHS危险声明: H314; H314-H318
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A; P280-P305 + P351 + P338-P310
• 个人保护装置: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 3265 8/PG 2
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥90%; ≥97.0% (GC); ≥98.5% (GC); 90%; 97%
• 级别: puriss.; purum
• 线性分子式: [(CH3)2CH]2Si(Cl)OSi(Cl)[CH(CH3)2]2

详细说明

MP Biomedicals - 02157657

Purity: 90%
1 ml = approx. 1.0 g

Sigma Aldrich - 337005

包装
1, 5 g in glass bottle

Sigma Aldrich - 36520

Other Notes
用于同时保护核苷的 3′- 和 5′-羟基官能团的试剂1,2；糖类的基团保护试剂3,4

参考文献

• Reagent for the protection of diols, including carbohydrate-type molecules, as their 1,3-(1,1,3,3-tetraisopropyldisiloxanylidene) (TIPDS) derivatives, formed in the presence of imidazole: J. Chem. Res. Synop., 24 (1979); J. Org. Chem., 50, 1651 (1985), or pyridine-DMF: Tetrahedron, 41, 4545, 4557 (1985). The high steric demand of the TIPDS group enables discrimination between primary and secondary OH. It is readily cleaved by F^- (e.g. TBAF in THF) or by aqueous acid or base. See Appendix 4.