chlorotrimethylsilane

• ChemBase编号: 74408
• 分子式: C3H9ClSi
• 平均质量: 108.64206
• 单一同位素质量: 108.0162045
• SMILES: [Si](C)(C)(C)Cl
• Canonical SMILES: C[Si](Cl)(C)C
• InChI: InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• InChIKey: IJOOHPMOJXWVHK-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: chlorotrimethylsilane
• IUPAC传统名: chlorotrimethylsilane
• 别名: 三甲基氯硅烷 溶液; 三甲基硅基氯; 三甲基氯硅烷; 三甲基氯硅烷 溶液; 三甲基氯硅烷/邻二甲苯 1/24 (v/v); 硅烷化溶液 IV; 硅烷 M3; Chlorotrimethylsilane solution; Dow Corning® Z-1224; Chlorotrimethylsilane; Chlorotrimethylsilane solution; Trimethylchlorosilane/o-Xylene 1/24 (v/v); Silanization solution IV; Trimethylsilyl chloride; TMCS; Chlorotrimethylsilane 99%; Chlorotrimethylsilane; TMSCl; Trimethylchlorosilane; Trimethylsilyl chloride; Silane M3; Chlorotrimethylsilane; TMS chloride

登记号

• CAS号: 75-77-4
• EC号: 200-900-5
• MDL号: MFCD00000502
• Beilstein号: 1209232
• PubChem SID: 24863995; 24864026; 24892952; 24890169; 24864097; 24889641; 162039327; 24888307
• PubChem CID: 6397
• Chemspider ID: 6157
• 维基百科标题: Trimethylsilyl_chloride

理论计算性质

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): 2.0128
• LogD (pH = 7.4): 2.0128
• Log P: 2.0128
• 摩尔折射率: 23.4766 cm^3
• 极化性: 11.012379 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: reacts in water
• 外观: Colorless liquid, fumes in moist air
• 熔点: -40 °C (233.2 K); -40 °C(lit.); -58°C; ca -58°C
• 沸点: 56-58°C; 56-58°C; 57 °C (330.2 K); 57 °C(lit.)
• 闪点: -.4 °F; 104 °F; -18 °C; -18°C; -20 °C; -27°C(-16°F); -28 °C; 39.2 °F; 4 °C; -4 °F; 40 °C
• 自燃点: 400 °C; 752 °F
• 密度: 0.856; 0.856 g/cm^3, liquid; 0.856 g/mL at 25 °C(lit.); 0.88 g/mL at 25 °C; 1.257 g/mL at 25 °C
• 折射率: 1.387; 1.3887; n20/D 1.387(lit.); n20/D 1.500
• 蒸汽压: 100 mmHg ( 25 °C)
• 蒸汽密度: 3.7 (vs air)

安全信息

• 保存注意事项: Highly Flammable/Corrosive/Harmful/Moisture Sensitive/Store under Argon/Keep Cold; Moisture Sensitive
• RTECS编号: VV2710000
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C); Corrosive (C); 易燃性(Flammable) (F); Flammable (F); X; 有害性(Harmful) (Xn)
• 联合国危险货物编号: 1298; 1993; 2920; 2924; UN1298
• 德国WGK号: 1; 2
• 联合国危险货物等级: 3; 8
• 联合国危险货物包装类别(PG): 2; II
• 危险公开号: 10-14-34-40; 11-14-19-35-37; 11-14-20/21-35-37; 11-14-21-34; 11-20/21-36/38; R11, R14, R20, R21, R35, R37
• 安全公开号: 16-26-36/37; 16-26-36/37/39-45; 26-36/37/39-45; 7/9-16-26-36/37/39-45; 8-16-26-30-36/37/39-45-60; S16, S26, S36, S37, S39, S45
• TSCA收录: 是
• GHS危险品标识: GHS02; GHS05; GHS06; GHS07; GHS08
• GHS警示词: Danger
• NFPA704:
  

  3

  3
• 爆炸极限: 6.4 %
• GHS危险声明: H225-H311-H314-H318; H225-H312-H314-H331-H335; H225-H312-H315-H318-H332; H225-H314-H335; H226-H314-H351
• GHS警示性声明: P210-P261-P280-P305 + P351 + P338-P310; P210-P280-P305 + P351 + P338; P210-P303+P361+P353-P305+P351+P338-P361-P405-P501A; P280-P305 + P351 + P338-P310
• 个人保护装置: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US); Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 1298 3/PG 2; UN 1993 3/PG 2; UN 2920 8/PG 2; UN 2924 3/PG 2
• 欧盟补充危害声明: May form explosive peroxides., Reacts violently with water.; Reacts violently with water.

产品相关信息

• 纯度: ≥97%; ≥98.0% (GC); ≥99%; ≥99.0% (GC); 97%; 98+%
• 浓度: ~1 M in THF; 1.0 M in methylene chloride; 1.0 M in THF
• 级别: produced by Wacker; puriss.; purum; Selectophore™
• 杂质: <0.1% dichlorodimethylsilane
• 提纯方法: glass distillation; redistillation
• 线性分子式: (CH3)3SiCl

详细说明

Sigma Aldrich - 385433

包装
800 mL in Sure/Seal™

Sigma Aldrich - C72854

Application
用于制备 GC 分析所需各种化合物的挥发性衍生物。
包装
100, 500 mL in Sure/Seal™
5 mL in glass bottle
View returnable container options.
法律信息
Dow Corning 注册商标 The Dow Chemical Company or an affiliated company of Dow

Sigma Aldrich - 92361

Application
Used in Fisher Glycosylation
包装
1 L in glass bottle
100, 250, 500 mL in glass bottle

Sigma Aldrich - 95541

Application
Used in Fisher Glycosylation
Other Notes
硅烷 M3
根据要求提供批量采购价
包装
5 kg in ss drum
500 g in Sure/Seal™

Sigma Aldrich - 384410

包装
100, 800 mL in Sure/Seal™

Sigma Aldrich - 92360

Other Notes
硅烷化试剂1,2

Sigma Aldrich - 386529

Application
Used in Fisher Glycosylation
包装
1 L in Sure/Seal™
25, 100 mL in Sure/Seal™

Sigma Aldrich - 85120

General description
请访问 传感器应用门户网站 了解更多信息。
Other Notes
通过浸渍烘焙方法用于硅烷化微电极移液管的即用型溶液1,2
法律信息
Selectophore 商标 Sigma-Aldrich GmbH

参考文献

• For facile O-silylation of tertiary alcohols in the presence of Mg metal, see: Synlett, 1025 (2000).
• Carbonyl compounds can be converted to their silyl enol ethers, e.g. with triethylamine in DMF: Org. Synth. Coll., 6, 327 (1988); 7,424 (1990); 8, 460 (1993); or using catalysis with NaI: Org. Synth. Coll., 9, 573 (1998).
• Conjugated enones give trimethylsilyloxydienes. For examples, see: Org. Synth. Coll., 6, 445 (1988); 7, 282 (1990). TMS chloride, LiBr and trimethylamine in THF is a convenient system for silylation of enones: Acta Chem. Scand., 43, 188 (1989). The same combination converts ɑ- and ?-diketones to their bis silyl enol ethers: Acta Chem. Scand., 43, 304 (1989). See also Trimethylsilyl trifluoromethanesulfonate, A12535.
• The conversion of alcohols to alkyl chlorides requires catalysis, e.g. SeO₂: J. Org. Chem., 53, 3634 (1988), or by DMSO: J. Org. Chem., 60, 2638 (1995). The same system is also effective in opening epoxides.
• For cleavage of ethers, see Sodium iodide, A15480.
• Silylation at carbon atoms is usually carried out using organometallic reagents, e.g. vinylmagnesium bromide: Org. Synth. Coll., 6, 1033 (1988). In aromatic rings, silyl groups can be introduced by directed metallation, followed by silylation; see e.g.: J. Org. Chem., 49, 4657 (1989). The silyl substituents can readily be replaced by electrophiles, allowing "abnormal" patterns of substitution. See 1,3-Dimethoxybenzene, A13380.
• For further details and reviews, see Appendix 4.