N-{2-[bis(propan-2-yl)amino]ethyl}-2-(2-oxopyrrolidin-1-yl)acetamide

• ChemBase编号: 73294
• 分子式: C14H27N3O2
• 平均质量: 269.38308
• 单一同位素质量: 269.21032712
• SMILES: C(C(=O)NCCN(C(C)C)C(C)C)N1C(=O)CCC1
• Canonical SMILES: O=C(CN1CCCC1=O)NCCN(C(C)C)C(C)C
• InChI: InChI=1S/C14H27N3O2/c1-11(2)17(12(3)4)9-7-15-13(18)10-16-8-5-6-14(16)19/h11-12H,5-10H2,1-4H3,(H,15,18)
• InChIKey: ZULJGOSFKWFVRX-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: N-{2-[bis(propan-2-yl)amino]ethyl}-2-(2-oxopyrrolidin-1-yl)acetamide
• IUPAC传统名: pramiracetam
• 别名: Pramiracetam

登记号

• CAS号: 68497-62-1
• PubChem SID: 162038214
• PubChem CID: 51712

理论计算性质

• Acid pKa: 15.849032
• 质子受体: 3
• 质子供体: 1
• LogD (pH = 5.5): -3.3008301
• LogD (pH = 7.4): -2.0830343
• Log P: 0.10419401
• 摩尔折射率: 76.312 cm^3
• 极化性: 29.734663 Å^3
• 极化表面积: 52.65 Å^2
• 可自由旋转的化学键: 7
• 里宾斯基五规则: true

分子性质

安全信息

• 保存条件: -20°C

产品相关信息

• 成盐信息: Free Base

详细说明

Selleck Chemicals - S2594

Research Area: Neurological Disease
Biological Activity:
Pramiracetam is a more potent nootropic drug derived from piracetam. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. Pramiracetam was also effective in the treatment of cognitive disorders of cerebrovascular and traumatic origins. In a study, two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food. This procedure permitted a distinction between working memory (short-term) and reference memory (long-term). Both doses of pramiracetam significantly enhanced performance in the reference memory component of the task, but did not significantly affect the working memory component. These data suggest that pramiracetam can improve some aspects of spatial learning and memory in the rat. [1][2][3]References on Pramiracetam[1] Psychopharmacology (Berl). , 1986, 89(3):378-81[2] http://en.wikipedia.org/wiki/Pramiracetam, , [3] Drugs., 2010 Feb 12, 70(3):287-312