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SMILES: c1ccc(c(c1)N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2)OC.Cl.Cl Canonical SMILES: COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2.Cl.Cl InChI: InChI=1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H InChIKey: NIBOMXUDFLRHRV-UHFFFAOYSA-N
CBID:73169 http://www.chembase.cn/molecule-73169.html
α2C-adrenoceptor
α1D-adrenoceptor
6.54 (pKi) [1]
8.2 (pKi) [2]
BMY 7378 inhibits 5-HT release induced by 8-OH-DPAT, but this effect is attenuated by pretreatment with the 5-HT1 receptor/beta-adrenoceptor antagonist pindolol (8 mg/kg s.c.), while the effect is not alter by pretreatment with a combination of the beta 1- and beta 2-adrenoceptor antagonists metoprolol (4 mg/kg s.c.) and ICI 118 551 (4 mg/kg s.c.). [4]