3,4,10,11-tetramethoxy-7,8-dihydro-6$l^{5}-azatetraphen-6-ylium chloride

• ChemBase编号: 73017
• 分子式: C21H22ClNO4
• 平均质量: 387.85668
• 单一同位素质量: 387.12373587
• SMILES: c1c(c(c2c(c1)cc1[n+](c2)CCc2c1cc(c(c2)OC)OC)OC)OC.[Cl-]
• Canonical SMILES: COc1cc2CC[n+]3c(c2cc1OC)cc1c(c3)c(OC)c(cc1)OC.[Cl-]
• InChI: InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1
• InChIKey: RLQYRXCUPVKSAW-UHFFFAOYSA-M

名称和登记号

名称

• IUPAC标准名: 3,4,10,11-tetramethoxy-7,8-dihydro-6$l^{5}-azatetraphen-6-ylium chloride; 3,4,10,11-tetramethoxy-7,8-dihydro-6λ^5-azatetraphen-6-ylium chloride
• IUPAC传统名: palmatine chloride
• 别名: Palmatine hydrochloride; Palmatine chloride; 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride

登记号

• CAS号: 10605-02-4
• PubChem SID: 162037937
• PubChem CID: 73442

理论计算性质

• 质子受体: 4
• 质子供体: 0
• LogD (pH = 5.5): -1.2218883
• LogD (pH = 7.4): -1.2218883
• Log P: -1.2218883
• 摩尔折射率: 100.6828 cm^3
• 极化性: 41.039276 Å^3
• 极化表面积: 40.8 Å^2
• 可自由旋转的化学键: 4
• 里宾斯基五规则: true

分子性质

安全信息

• 保存条件: -20°C

产品相关信息

• 成盐信息: chloride; Cl-

详细说明

Selleck Chemicals - S2397

Research Area: Neurological Disease
Biological Activity:
Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) is a hydrochloride salt of palmatine which is a protoberberine alkaloid. Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. [1] Palmatine inhibited carbachol-induced Ca2+-activated Cl− secretion and the carbachol-induced increase of intracellular Ca2+ concentration. Palmatine also inhibited cAMP-activated Cl− secretion induced by prostaglandin E2 (PGE2) or forskolin. Palmatine prevented the elevation of intracellular cAMP by forskolin. Determination of apical Cl− currents showed that palmatine suppressed the forskolin-stimulated, apical cAMP-activated Cl− current but not the carbachol-stimulated apical Ca2+-activated Cl− current. [2]

参考文献

• Wu DZ et al. Br J Pharmacol. 2008 Mar;153(6):1203-13.