(2S,3S,4S,5R,6S)-6-{[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-5-{[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-3,4-dihydroxyoxane-2-carboxylic acid amine

• ChemBase编号: 73000
• 分子式: C42H65NO16
• 平均质量: 839.9626
• 单一同位素质量: 839.43033501
• SMILES: [C@@]1(CC[C@]2([C@@H](C1)C1=CC(=O)[C@H]3[C@]([C@@]1(CC2)C)(CC[C@@H]1[C@@]3(CC[C@@H](C1(C)C)O[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(=O)O)O)O)O)O)O)C(=O)O)C)C)C)(C)C(=O)O.N
• Canonical SMILES: O[C@@H]1[C@@H](O[C@@H]2O[C@H](C(=O)O)[C@H]([C@@H]([C@H]2O)O)O)[C@H](O[C@@H]([C@H]1O)C(=O)O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2C(=O)C=C2[C@@]1(C)CC[C@@]1([C@H]2C[C@](C)(CC1)C(=O)O)C)C)C.N
• InChI: InChI=1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
• InChIKey: ILRKKHJEINIICQ-OOFFSTKBSA-N

名称和登记号

名称

• IUPAC标准名: (2S,3S,4S,5R,6S)-6-{[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-5-{[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-3,4-dihydroxyoxane-2-carboxylic acid amine
• IUPAC传统名: glyzyrrhizin amine
• 别名: 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid 铵盐; 甘草甜; 甘草酸 铵盐 来源于甘草根（甘草）; AMGZ; Ammonium Glycyrrhizinate; Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice); 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid ammonium salt; Glycyrrhizin

登记号

• CAS号: 53956-04-0; 1407-03-0
• EC号: 258-887-7
• MDL号: MFCD00167400
• Beilstein号: 3897076
• PubChem SID: 24873374; 162037920; 24895085
• PubChem CID: 62074

理论计算性质

• Acid pKa: 2.961005
• 质子受体: 16
• 质子供体: 8
• LogD (pH = 5.5): -2.329018
• LogD (pH = 7.4): -6.5692225
• Log P: 3.1302059
• 摩尔折射率: 198.8299 cm^3
• 极化性: 80.55014 Å^3
• 极化表面积: 267.04 Å^2
• 可自由旋转的化学键: 7
• 里宾斯基五规则: false

分子性质

理化性质

• 比旋光度: [α]20/D +48±4°, c = 1% in ethanol: water (1:1)
• 甜度: 50 × sucrose

安全信息

• 保存条件: -20°C
• RTECS编号: LZ6500000
• 德国WGK号: 2
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥70% (HPLC); ≥95.0% (NT)
• 成盐信息: Glycyrrhizinate
• 杂质: ≤7% water
• 线性分子式: C42H62O16 · NH3

详细说明

Selleck Chemicals - S2376

Research Area: Metabolic Disease
Biological Activity:
Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. It is an excellent foaming agent that acts as a co-emulsifier. It is also excellent in recipes that require gelling or suspension properties for a consistent feeling in the mouth or a stable cloud effect in the product.Very small quantities are required to achieve the desired results, usually a few parts per million. However, varying amounts should be evaluated in your product for best taste.MAGZ is up to 50 times sweeter than sucrose — and can greatly enhance an already sweetened product as a result of synergies with both natural and synthetic sweeteners. It was found to be active against viruses, while not affecting cell activity and ability to replicate. It was also reported that glycyrrhizic acid inactivates herpes simplex particles irreversibly. [1]

Sigma Aldrich - 50531

Biochem/physiol Actions
甘草属（甘草）甜根中的生物活性组分。抗病毒。

Sigma Aldrich - G2137

Biochem/physiol Actions
甘草属（甘草）甜根中的生物活性组分。抗病毒。
包装
25, 100 g in poly bottle

参考文献

• van Rossum TG et al. Am J Gastroenterol. 2001 Aug;96(8):2432-7.