(6S)-6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole hydrochloride

• ChemBase编号: 72824
• 分子式: C11H13ClN2S
• 平均质量: 240.75232
• 单一同位素质量: 240.04879711
• SMILES: [C@@H]1(CN2C(=N1)SCC2)c1ccccc1.Cl
• Canonical SMILES: C1CN2C(=N[C@H](C2)c2ccccc2)S1.Cl
• InChI: InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
• InChIKey: LAZPBGZRMVRFKY-HNCPQSOCSA-N

名称和登记号

名称

• IUPAC标准名: (6S)-6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole hydrochloride
• IUPAC传统名: levamisole hydrochloride; levamisole hydrochloride hydrochloride
• 别名: (-)-四咪唑/驱虫净 盐酸盐; 左旋咪唑 盐酸盐; 左咪唑 盐酸盐; (-)-四咪唑/驱虫净 盐酸盐; (S)-(-)-6-苯基-2,3,5,6-四氢咪唑并[2,1-b]噻唑 盐酸盐; L(-)-2,3,5,6-四氢-6-苯基咪唑并(2,1-b)噻唑 盐酸盐; Ergamisol; Levamisole Hydrochloride; (-)-Tetramisole hydrochloride; (S)-(-)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride; L(-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride; Levamisole hydrochloride; Levamisol hydrochloride; (6S)-6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole hydrochloride; (-)-Tetramisole hydrochloride; (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride

登记号

• CAS号: 16595-80-5
• EC号: 240-654-6
• MDL号: MFCD00012675
• Beilstein号: 4358988
• PubChem SID: 24870601; 24278526; 162037745
• PubChem CID: 27944

理论计算性质

• 质子受体: 2
• 质子供体: 0
• LogD (pH = 5.5): 0.91581506
• LogD (pH = 7.4): 2.220205
• Log P: 2.358227
• 摩尔折射率: 60.0784 cm^3
• 极化性: 23.02744 Å^3
• 极化表面积: 15.6 Å^2
• 可自由旋转的化学键: 1
• 里宾斯基五规则: true

分子性质

理化性质

• 熔点: 228-230 °C
• 疏水性(logP): 1.844

安全信息

• 保存条件: -20°C
• RTECS编号: NJ5960000
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 联合国危险货物编号: 2811
• 德国WGK号: 3
• 联合国危险货物等级: 6.1
• 联合国危险货物包装类别(PG): 3
• 危险公开号: 25
• 安全公开号: 36/37/39-45
• GHS危险品标识: GHS06
• GHS警示词: Danger
• GHS危险声明: H301
• GHS警示性声明: P301 + P310
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• RID/ADR: UN 2811 6.1/PG 3

产品相关信息

• 纯度: ≥99% (GC); 95%; 95+%
• 级别: VETRANAL™, analytical standard
• 成盐信息: Hcl
• Empirical Formula (Hill Notation): C11H12N2S · HCl

详细说明

Selleck Chemicals - S1939

Research Area: Immunology
Biological Activity:
Levamisole Hydrochloride(Ergamisol)is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. [1]

Sigma Aldrich - L9756

Application
Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited. Not for veterinary use.
Biochem/physiol Actions
Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors.1 Very effective in treatment of ascariasis (hookworm infestation).2 Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.3
包装
5, 10 g in poly bottle
Other Notes
Levamisole hydrochloride is soluble in water at 50mg/mL yielding a clear, colorless solution. Solutions are stable at 2-8°C for ~1 month.

Sigma Aldrich - 31742

Biochem/physiol Actions
Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors.1 Very effective in treatment of ascariasis (hookworm infestation).2 Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.3
法律信息
VETRANAL 商标 Sigma-Aldrich Co. LLC

参考文献

• http://www.drugbank.ca/drugs/DB00848