1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

• ChemBase编号: 69886
• 分子式: C9H12N2O6
• 平均质量: 244.20138
• 单一同位素质量: 244.06953611
• SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O1)n1c(=O)[nH]c(=O)cc1
• Canonical SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc(=O)[nH]c1=O
• InChI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
• InChIKey: DRTQHJPVMGBUCF-XVFCMESISA-N

名称和登记号

名称

• IUPAC标准名: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC传统名: uridine; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• 别名: 尿苷; 尿嘧啶-1-β-D-呋喃核糖苷; 尿嘧啶核苷; 5′-脱氧尿苷; 1-β-D-Ribofuranosyluracil; Uracil-1-β-D-ribofuranoside; Uridine; 5′-Deoxyuridine; Uridine; Arabinosyl-Uracil; 1-β-D-Arabinofuranosyluracil; URACIL-β-D-ARABINOFURANOSIDE; uridine

登记号

• CAS号: 58-96-8; 15958-99-3
• EC号: 221-386-9; 200-407-5
• MDL号: MFCD00006526
• Beilstein号: 754902
• PubChem SID: 162035611; 24900640; 24900638; 24900434
• PubChem CID: 6029
• CHEMBL: 100259
• DrugBank ID: DB02745
• 医学主题词(MeSH): Uridine
• 美国药典/FDA物质标识码: WHI7HQ7H85
• 维基百科标题: Uridine

理论计算性质

• Acid pKa: 9.700741
• 质子受体: 6
• 质子供体: 4
• LogD (pH = 5.5): -2.4152691
• LogD (pH = 7.4): -2.4173849
• Log P: -2.4152422
• 摩尔折射率: 52.5656 cm^3
• 极化性: 20.901344 Å^3
• 极化表面积: 119.33 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: H2O: soluble0.1 M, clear, colorless; H2O: soluble50 mg/mL
• 外观: powder; Powder
• 熔点: 163-167 °C; 163-167 °C(lit.)
• 比旋光度: [α]20/D +9.5±1°, c = 2% in H2O

安全信息

• 保存条件: 0°C; -20°C
• 保存注意事项: IRRITANT
• RTECS编号: YQ8818000
• 德国WGK号: 3
• TSCA收录: false
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

药理学性质

• 作用靶点: DNA; RNA Synthesis
• 相关基因信息: mouse ... Uck1(22245)
• 生物活性机理: Antimetabolite

产品相关信息

• 纯度: ≥99%; ≥99.0% (HPLC); 95+%; 99%
• 成盐信息: Free Base
• 适用性: suitable for cell culture
• 燃烧残渣: ≤0.1%
• 杂质: ≤0.005% Phosphorus (P); ≤0.1% Insoluble matter
• 痕量阳离子: Al: ≤0.0005%; Ca: ≤0.01%; Cu: ≤0.0005%; Fe: ≤0.003%; K: ≤0.005%; Mg: ≤0.003%; Na: ≤0.02%; NH4+: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• 痕量阴离子: sulfate (SO42-): ≤0.05%
• 生物来源: Widely distributed in nature
• 应用领域: Virucide
• 品质说明: crystallized
• 产品线: BioReagent; BioUltra
• Empirical Formula (Hill Notation): C9H12N2O5; C9H12N2O6

详细说明

MP Biomedicals - 02100074

Crystalline

Selleck Chemicals - S202

Research Area: DNA/RNA
Biological Activity:

Sigma Aldrich - U3750

包装
1, 25, 100 g in poly bottle