(2S)-2,5-diaminopentanoic acid hydrochloride

• ChemBase编号: 69818
• 分子式: C5H13ClN2O2
• 平均质量: 168.62192
• 单一同位素质量: 168.06655535
• SMILES: C(=O)([C@@H](N)CCCN)O.Cl
• Canonical SMILES: N[C@H](C(=O)O)CCCN.Cl
• InChI: InChI=1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
• InChIKey: GGTYBZJRPHEQDG-WCCKRBBISA-N

名称和登记号

名称

• IUPAC标准名: (2S)-2,5-diaminopentanoic acid hydrochloride
• IUPAC传统名: ornithine hydrochloride
• 别名: (S)-2,5-二氨基戊酸 单盐酸盐; L-鸟氨酸 单盐酸盐; (S)-(+)-2,5-二氨基戊酸 盐酸盐; L-鸟氨酸 单盐酸盐; L-鸟氨酸 盐酸盐; L-鸟氨酸盐酸盐; (S)-2,5-Diaminopentanoic Acid Hydrochloride; L-(+)-Ornithine Monohydrochloride; (S)-α,δ-Diaminovaleric Acid; 5-Amino-L-norvaline; L-Ornithine monohydrochloride; L-2,5-Diaminopentanoic acid; (S)-(+)-2,5-Diaminopentanoic acid hydrochloride; (S)-2,5-Diaminopentanoic acid monohydrochloride; L-Ornithine monohydrochloride; L-Ornithine hydrochloride; L-Ornithine hydrochloride; H-Orn-OH.HCl

登记号

• CAS号: 3184-13-2
• EC号: 221-678-6
• MDL号: MFCD00064562
• Beilstein号: 3625847
• 默克索引号: 146874
• PubChem SID: 24886830; 24897960; 24898036; 162035543; 24897996
• PubChem CID: 76654
• FEMA编号: 4190

理论计算性质

• Acid pKa: 2.6664226
• 质子受体: 4
• 质子供体: 3
• LogD (pH = 5.5): -6.399376
• LogD (pH = 7.4): -5.4160175
• Log P: -3.6582875
• 摩尔折射率: 33.2085 cm^3
• 极化性: 13.533871 Å^3
• 极化表面积: 89.34 Å^2
• 可自由旋转的化学键: 4
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: H2O: soluble1 M at 20 °C, clear, colorless; H2O: soluble1 M at 20 °C, clear, faintly yellow; Water
• 外观: White Solid
• 熔点: 233°C (dec.); 239-241°C; 245 °C (dec.)(lit.); ca 238°C dec.
• 比旋光度: [α]20/D +23.0±0.5°, c = 5% in 5 M HCl; [α]24/D +23.6°, c = 4 in 6 M HCl; +23 (c=5 in 5N HCl)
• 紫外吸收波长: λ: 260 nm Amax: 0.06; λ: 280 nm Amax: 0.06
• pH值: 5.0-6.0 (25 °C, 1 M in H2O)

安全信息

• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere; Room Temperature (15-30°C)
• 保存注意事项: IRRITANT
• RTECS编号: RM2985000
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 2
• 危险公开号: 36
• 安全公开号: 26
• TSCA收录: false; 是
• GHS危险品标识: GHS07
• GHS警示词: Warning
• GHS危险声明: H319
• GHS警示性声明: P305 + P351 + P338
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

药理学性质

• 过敏源: no known allergens

产品相关信息

• 纯度: ~99%; ≥99%; ≥99.0% (AT); ≥99.5% (AT); 95+%; 99%
• 适用性: suitable for cell culture
• 燃烧残渣: ≤0.1%; ≤0.1% (as SO4)
• 杂质: ≤0.005% Phosphorus (P); ≤0.1% Insoluble matter; ≤0.3% foreign amino acids; ammonia and citrulline, essentially free; ammonia- and citrulline-free, essentially free; insoluble matter, passes filter test
• 痕量阳离子: Al: ≤0.0005%; Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤0.005%; Ca: ≤10 mg/kg; Ca: ≤60 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤0.0005%; Cu: ≤5 mg/kg; Fe: ≤0.0005%; Fe: ≤5 mg/kg; K: ≤0.005%; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤0.0005%; Mg: ≤10 mg/kg; Mg: ≤5 mg/kg; Mn: ≤10 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤0.005%; Na: ≤50 mg/kg; NH4+: ≤0.05%; NH4+: ≤100 mg/kg; NH4+: ≤200 mg/kg; Ni: ≤5 mg/kg; Pb: ≤0.001%; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤0.0005%; Zn: ≤5 mg/kg
• 痕量阴离子: sulfate (SO42-): ≤0.05%; sulfate (SO42-): ≤100 mg/kg; sulfate (SO42-): ≤50 mg/kg
• 干燥失重: ≤0.1% loss on drying, 20 °C (HV); ≤0.5% loss on drying, 110 °C
• λ: 1 M in H2O
• 产品线: BioXtra
• 线性分子式: NH2(CH2)3CH(CO2H)(NH2) · HCl
• Empirical Formula (Hill Notation): C5H12N2O2 · HCl

详细说明

MP Biomedicals - 02194718

Cell Culture Reagent
Hydrochloride
Crystalline
Purity: ~99%
This material is essentially free of citrulline and ammonia.

MP Biomedicals - 02100421

Hydrochloride
Crystalline
Purity: ~99%
This material is essentially free of citrulline and ammonia.

Sigma Aldrich - O6503

Other Notes
精氨酸通过精氨酸酶降解所得产物
Application
Use as a media supplement to support the biosynthesis of polyamines.
General description
L-Ornithine is an amino acid that is not coded for by the genetic code. It is formed during the decomposition of argininine by arginase and participates in the urea cycle. Ornithine is the starting point for the formation of a family of polyamines that include spermine, spermidine and putrescine.

Sigma Aldrich - O2375

Other Notes
精氨酸通过精氨酸酶降解所得产物
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. O2375.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
包装
1 kg in poly bottle
10 mg in autosmp vl
5, 25, 100 g in poly bottle
Biochem/physiol Actions
L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle.

Sigma Aldrich - 75469

Other Notes
精氨酸通过精氨酸酶降解所得产物

Sigma Aldrich - O4386

Other Notes
精氨酸通过精氨酸酶降解所得产物
Biochem/physiol Actions
L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle.

Sigma Aldrich - W419001

包装
1 kg in poly bottle
1 sample in glass bottle
100 g in poly bottle

Sigma Aldrich - O8305

包装
25 g in poly bottle

Sigma Aldrich - 75470

Other Notes
精氨酸通过精氨酸酶降解所得产物

Toronto Research Chemicals - O695550

L-Ornithine is a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chick

参考文献

• Fattori, D., et al.: J. Med. Chem., 50, 550 (2007)
• Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007)
• Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2007)