hexanedihydrazide

• ChemBase编号: 52248
• 分子式: C6H14N4O2
• 平均质量: 174.20096
• 单一同位素质量: 174.11167571
• SMILES: C(=O)(CCCCC(=O)NN)NN
• Canonical SMILES: NNC(=O)CCCCC(=O)NN
• InChI: InChI=1S/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)
• InChIKey: IBVAQQYNSHJXBV-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: hexanedihydrazide
• IUPAC传统名: adipic acid dihydrazide
• 别名: 己二酸二酰肼; Adipic acid dihydrazide; adipohydrazide; Adipohydrazide; Adipyl hydrazide; Adipic dihydrazide; Adipic acid dihydrazide; ADIPYL HYDRAZIDE; hexanediohydrazide; 1,4-Butanedicarboxylic dihydrazide; Hexanedioic dihydrazide; Adipic dihydrazide

登记号

• CAS号: 1071-93-8
• EC号: 213-999-5
• MDL号: MFCD00007614
• Beilstein号: 973863
• PubChem SID: 162057011; 24890442; 24845239
• PubChem CID: 66117
• Chemspider ID: 59505
• 医学主题词(MeSH): Adipic+dihydrazide
• 维基百科标题: Adipic_acid_dihydrazide

理论计算性质

• Acid pKa: 12.649596
• 质子受体: 4
• 质子供体: 4
• LogD (pH = 5.5): -1.7212892
• LogD (pH = 7.4): -1.716249
• Log P: -1.7161822
• 摩尔折射率: 45.3516 cm^3
• 极化性: 17.123558 Å^3
• 极化表面积: 110.24 Å^2
• 可自由旋转的化学键: 5
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: H2O: soluble100 mg/mL
• 熔点: 176–185 °C; 180-182 °C; 180-182 °C(lit.); 180-182°C; 180-182°C
• 闪点: 150 °C; 302 °F

安全信息

• 保存注意事项: IRRITANT; Irritant
• RTECS编号: AV1400000
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 3
• 危险公开号: 36/37/38
• 安全公开号: 26-37
• TSCA收录: false; 是
• GHS危险品标识: GHS07
• GHS危险声明: H315-H319-H335
• GHS警示性声明: P280G-P305+P351+P338
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C

产品相关信息

• 纯度: ≥97.0% (NT); ≥98%; 95%; 97%; 98%
• 级别: purum
• 产品质量级别: PREMIUM
• 线性分子式: NH2NHCO(CH2)4CONHNH2

详细说明

MP Biomedicals - 05213452

MP Biomedicals Rare Chemical collection

Sigma Aldrich - A0638

Application
Homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. Typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Other Notes
Note that the hydrazone bond may be stabilized by selective reduction using, for example, sodium cyanoborohydride.
包装
25, 100 g in poly bottle

Sigma Aldrich - 02191

Other Notes
Bifunctional linker employed for the immobilization of carbohydrates, e.g. to MMAC resins (methyl vinyl ether, maleic anhydride co-polymer)1,2
Application
Adipic acid dihydrazide can be used to study chemical synthesis, organic building blocks, carbonyl compounds and hydrazides. Adipic acid dihydrazide has been used in a study to show that diphtheria toxoid can be successfully employed as a carrier protein for conjugation with Salmonella O-specific polysaccharides and play an important role in facilitating adequate immune response in typhoid fever vaccines. Adipic acid dihydrazide has also been used in a study to assess the activity of the derivatives of glycoside steviolbioside from the plant Stevia rebaudiana.

Sigma Aldrich - 217824

包装
25 g in poly bottle