2,17,18-trimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-ol

• ChemBase编号: 4455
• 分子式: C21H32N2O
• 平均质量: 328.49158
• 单一同位素质量: 328.25146365
• SMILES: CC12Cc3c[nH]nc3CC1CCC1C2CCC2(C)C1CCC2(C)O
• Canonical SMILES: CC12Cc3c[nH]nc3CC1CCC1C2CCC2(C1CCC2(C)O)C
• InChI: InChI=1S/C21H32N2O/c1-19-11-13-12-22-23-18(13)10-14(19)4-5-15-16(19)6-8-20(2)17(15)7-9-21(20,3)24/h12,14-17,24H,4-11H2,1-3H3,(H,22,23)
• InChIKey: LKAJKIOFIWVMDJ-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 2,17,18-trimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-ol
• IUPAC传统名: 2,17,18-trimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-ol
• 商标名: Winstrol; Winstrol Depot (intramuscular injection); Stromba
• 别名: Stanozolol

登记号

• CAS号: 10418-03-8
• PubChem SID: 160967887; 99443270
• PubChem CID: 5277

理论计算性质

JChem

• Acid pKa: 16.234053
• 质子受体: 2
• 质子供体: 2
• LogD (pH = 5.5): 3.8062527
• LogD (pH = 7.4): 3.8072276
• Log P: 3.80724
• 摩尔折射率: 96.7977 cm^3
• 极化性: 37.831547 Å^3
• 极化表面积: 48.91 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: 4.33
• LOG S: -5.28
• 溶解度: 1.73e-03 g/l

详细说明

DrugBank - DB06718

• Drug Groups: approved
• Description: Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes.
• Indication: Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating C1-inhibitor deficient hereditary angioedema. C1-inhibitor is a protease that inhibits the complement system (part of the innate immune system), a biochemical chain of reactions which assists the body in removing pathogens from the body. Stanozolol may help control attacks of hereditary angioedema. Stanozolol can be administered orally or intramuscularly.
• Pharmacology: Stanozolol is a synthetic anabolic-androgenic steroid (AAS), which promotes cell growth (anabolism) and development/maintenance of masculine characteristics (androgenism).
• Half Life: 24 hours
• References: Guilarte M, Luengo O, Nogueiras C, Labrador-Horrillo M, Munoz E, Lopez A, Cardona V: Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. J Investig Allergol Clin Immunol. 2008;18(2):126-30. [Pubmed] ; Thevis M, Schanzer W: Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators. Handb Exp Pharmacol. 2010;(195):99-126. [Pubmed] ; Sloane DE, Lee CW, Sheffer AL: Hereditary angioedema: Safety of long-term stanozolol therapy. J Allergy Clin Immunol. 2007 Sep;120(3):654-8. [Pubmed]
• External Links: Wikipedia

参考文献

• Guilarte M, Luengo O, Nogueiras C, Labrador-Horrillo M, Munoz E, Lopez A, Cardona V: Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. J Investig Allergol Clin Immunol. 2008;18(2):126-30. Pubmed
• Thevis M, Schanzer W: Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators. Handb Exp Pharmacol. 2010;(195):99-126. Pubmed
• Sloane DE, Lee CW, Sheffer AL: Hereditary angioedema: Safety of long-term stanozolol therapy. J Allergy Clin Immunol. 2007 Sep;120(3):654-8. Pubmed