octafluoropropane

• ChemBase编号: 438
• 分子式: C3F8
• 平均质量: 188.0193256
• 单一同位素质量: 187.98722576
• SMILES: FC(F)(C(F)(F)F)C(F)(F)F
• Canonical SMILES: FC(C(F)(F)F)(C(F)(F)F)F
• InChI: InChI=1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChIKey: QYSGYZVSCZSLHT-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: octafluoropropane
• IUPAC传统名: perflutren; definity
• 商标名: Definity; Freon 218; Genetron 218; Octafluoropropane; Perfluoropropane; Perfluoropropane 99+%; Perfluoropropaneminimum; Perflutren [USAN]; Propane, octafluoro-
• 别名: Perflutren; Octafluoropropane; Perfluoropropane (PFC-218) 99.9%; Freon 218; Perfluoropropane; RC 218, PFC 218; R218; Flutec PP30; genetron 218; Octafluoropropane

登记号

• CAS号: 76-19-7
• MDL号: MFCD00039239
• PubChem SID: 160963901; 46506030
• PubChem CID: 6432
• CHEBI ID: 31980
• CHEMBL: 1663
• Chemspider ID: 6192
• DrugBank ID: DB00556
• KEGG ID: D01738
• 美国药典/FDA物质标识码: CK0N3WH0SR
• 维基百科标题: Octafluoropropane

理论计算性质

JChem

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): 2.78236
• LogD (pH = 7.4): 2.78236
• Log P: 2.78236
• 摩尔折射率: 17.5372 cm^3
• 极化性: 6.707999 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: 2.96
• LOG S: -3.11
• 溶解度: 1.46e-01 g/l

分子性质

理化性质

• 溶解度: 5.7 mg/L
• 外观: Colorless gas with; faintly sweet odor
• 熔点: -183 °C (90.15 K); -183°C
• 沸点: -36.7 °C (236.45 K); -39°C
• 闪点: N/A; none°C
• 密度: 1.352; 8.17 g/l, gas
• 疏水性(logP): 3

安全信息

• 保存注意事项: Flammable
• RTECS编号: TZ5255000
• 安全公开号: R R: ?; S: ?
• 主要危害: Suffocation
• NFPA704:
  

  1

详细说明

DrugBank - DB00556

• Drug Groups: approved
• Description: Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
• Indication: Use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border.
• Pharmacology: Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. It provide contrast enhancement of the endocardial borders during echocardiography. The perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood.
• Affected Organisms: Humans and other mammals
• Biotransformation: OFP is not metabolized. The phospholipid components of the microspheres are thought to be metabolized to free fatty acids.
• Half Life: The mean half-life of OFP in blood 1.9 minutes
• External Links: RxList; Drugs.com

Apollo Scientific Ltd - PC6210

Cylinder - 1/4" NPT connection