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60-32-2 分子结构
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6-aminohexanoic acid

ChemBase编号:395
分子式:C6H13NO2
平均质量:131.17292
单一同位素质量:131.09462866
SMILES和InChIs

SMILES:
OC(=O)CCCCCN
Canonical SMILES:
NCCCCCC(=O)O
InChI:
InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChIKey:
SLXKOJJOQWFEFD-UHFFFAOYSA-N

引用这个纪录

CBID:395 http://www.chembase.cn/molecule-395.html

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名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
6-aminohexanoic acid
IUPAC传统名
6-amino hexanoic acid
aminocaproic acid
商标名
Acepramin
Acepramine
Afibrin
Amicar
Amikar
Aminokapron
Atsemin
Caplamin
Capracid
Capramol
Capranol
Caprocid
Caprolisin
EACA
EACS
Epsamon
Epsicapron
Epsikapron
Epsilcapramin
Epsilcapramine
Hemocaprol
Hemopar
Hepin
Ipsilon
Respramin
别名
ε-氨基己酸
6-氨己酸
6-氨基己酸
6-氨己酸
6-氨基己酸
Aminocaproate
ACS
Aminocaproic
aminocaproic acid
ε-amino caproic acid
ε-Ahx
6-aminohexanoic acid
E-aminocaproic acid
Aminocaproic Acid
6-Amino-n-hexanoic acid
6-Aminocaproic acid
EACA
ε-AMINO-n-CAPROIC ACID
Amicar
6-Aminocaproic acid
6-Amino Hexanoic Acid
ε-Aminocaproic acid
6-Aminohexanoic acid solution
Additive Screening Solution 32/Fluka kit no 78374
6-Aminohexanoic acid
A 14719
Acepramin
Acepramine
Acikaprin
Afibrin
Amikar
Aminokapron
CL 10304
CY 116
Caplamin
Capramol
Caprocid
Caprolisin
EACS
Epsamon
Epsicapron
Epsikapron
Epsilcapramin
Epsilon S
Hemocaprol
Hemopar
Hepin
Ipsilon
NSC 212532
NSC 26154
NSC 400230
Respramin
ε-Amino-n-caproic Acid
ε-Amino-n-hexanoic Acid
ε-Aminohexanoic Acid
ε-Leucine
ε-Norleucine
ω-Aminocaproic Acid
ω-Aminohexanoic Acid
6-Aminohexanoic Acid
epsilon-Aminocaproic acid
CAS号
60-32-2
EC号
200-469-3
MDL号
MFCD00008238
Beilstein号
906872
默克索引号
14432
PubChem SID
160963858
24278238
46508972
46506934
24890662
PubChem CID
564

理论计算性质

理论计算性质

JChem ALOGPS 2.1
Acid pKa 4.72614  质子受体
质子供体 LogD (pH = 5.5) -2.050338 
LogD (pH = 7.4) -1.9963912  Log P -1.9971552 
摩尔折射率 34.6598 cm3 极化性 13.835553 Å3
极化表面积 63.32 Å2 可自由旋转的化学键
里宾斯基五规则 true 
Log P -2.69  LOG S -0.46 
溶解度 4.52e+01 g/l 

分子性质

分子性质

理化性质 安全信息 药理学性质 产品相关信息 生物活性(PubChem)
溶解度
5.05E+005 mg/L expand 查看数据来源
H2O: soluble0.5 M, clear expand 查看数据来源
H2O: soluble50 mg/mL expand 查看数据来源
Water expand 查看数据来源
外观
white powder expand 查看数据来源
White Solid expand 查看数据来源
熔点
203-205°C expand 查看数据来源
204-206 expand 查看数据来源
207-209 °C (dec.)(lit.) expand 查看数据来源
210-212°C expand 查看数据来源
密度
1.03 g/mL at 20 °C expand 查看数据来源
疏水性(logP)
0 expand 查看数据来源
-2.235 expand 查看数据来源
保存条件
-20°C expand 查看数据来源
-20°C Freezer expand 查看数据来源
Room Temperature (15-30°C) expand 查看数据来源
RTECS编号
MO6300000 expand 查看数据来源
欧盟危险性物质标志
刺激性(Irritant) 刺激性(Irritant) (Xi) expand 查看数据来源
MSDS下载
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
德国WGK号
2 expand 查看数据来源
危险公开号
36/37/38 expand 查看数据来源
安全公开号
26-36 expand 查看数据来源
TSCA收录
expand 查看数据来源
GHS危险品标识
GHS07 expand 查看数据来源
GHS警示词
Warning expand 查看数据来源
GHS危险声明
H315-H319 expand 查看数据来源
H315-H319-H335 expand 查看数据来源
GHS警示性声明
P261-P305 + P351 + P338 expand 查看数据来源
P305 + P351 + P338 expand 查看数据来源
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves expand 查看数据来源
Eyeshields, Gloves expand 查看数据来源
保存温度
2-8°C expand 查看数据来源
相关基因信息
human ... PLG(5340) expand 查看数据来源
human ... PLG(5340)rat ... Ppm1a(24666) expand 查看数据来源
纯度
≥98.5% (NT) expand 查看数据来源
≥99% expand 查看数据来源
≥99% (titration) expand 查看数据来源
≥99.0% g/mL expand 查看数据来源
95% expand 查看数据来源
98% expand 查看数据来源
99% expand 查看数据来源
浓度
1 M expand 查看数据来源
级别
puriss. expand 查看数据来源
SAJ special grade expand 查看数据来源
成盐信息
Free Base expand 查看数据来源
质检报告
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
包装
vial of 200 mg expand 查看数据来源
燃烧残渣
≤0.1% expand 查看数据来源
杂质
≤0.005% Phosphorus (P) expand 查看数据来源
≤0.1% Insoluble matter expand 查看数据来源
痕量阳离子
Al: ≤0.0005% expand 查看数据来源
Ca: ≤0.005% expand 查看数据来源
Cu: ≤0.0005% expand 查看数据来源
Fe: ≤0.0005% expand 查看数据来源
K: ≤0.005% expand 查看数据来源
Mg: ≤0.001% expand 查看数据来源
Na: ≤0.02% expand 查看数据来源
NH4+: ≤0.05% expand 查看数据来源
Pb: ≤0.001% expand 查看数据来源
Zn: ≤0.0005% expand 查看数据来源
痕量阴离子
chloride (Cl-): ≤0.05% expand 查看数据来源
sulfate (SO42-): ≤0.05% expand 查看数据来源
线性分子式
H2N(CH2)5CO2H expand 查看数据来源

详细说明

详细说明

DrugBank DrugBank Sigma Aldrich Sigma Aldrich MP Biomedicals MP Biomedicals Selleck Chemicals Selleck Chemicals TRC TRC
DrugBank -  DB00513 external link
Item Information
Drug Groups approved; investigational
Description An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. [PubChem]
Indication For use in the treatment of excessive postoperative bleeding.
Pharmacology Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity. Aminocaproic acid may be a possible prophylactic for vascular disease, as it may prevent formation of lipoprotein (a), a risk factor for vascular disease.
Toxicity A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Affected Organisms
Humans and other mammals
Biotransformation Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid.
Absorption Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Half Life The terminal elimination half-life is approximately 2 hours.
Elimination Renal excretion is the primary route of elimination, whether aminocaproic acid is administered orally or intravenously.
Distribution * 23.1 ± 6.6 L
Clearance * 169 mL/min
External Links
Wikipedia
RxList
Drugs.com
DrugBank -  DB04134 external link
Item Information
Drug Groups experimental
Description An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. [PubChem]
Sigma Aldrich -  A7824 external link
Biochem/physiol Actions
赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。1,2据报告,EACA 可抑制纤溶酶原结合至活化的血小板。3早期报告表明,EACA 可抑制补体系统第一组分的活化。4结合并灭活羧肽酶 B。5
Sigma Aldrich -  A2504 external link
包装
1 kg in poly bottle
25, 100, 500 g in poly bottle
5 kg in poly drum
Application
EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
Biochem/physiol Actions
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo-xy-peptidase, plasmin, and plasminogen activator.
赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。据报告,EACA 可抑制纤溶酶原结合至活化的血小板。早期报告表明,EACA 可抑制补体系统第一组分的活化。结合并灭活羧肽酶 B。
Sigma Aldrich -  07260 external link
Other Notes
Improves solubilization of membrane proteins in electrophoresis6
Biochem/physiol Actions
赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。1,2据报告,EACA 可抑制纤溶酶原结合至活化的血小板。3早期报告表明,EACA 可抑制补体系统第一组分的活化。4结合并灭活羧肽酶 B。5
Sigma Aldrich -  01-3540 external link
Biochem/physiol Actions
赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。1,2据报告,EACA 可抑制纤溶酶原结合至活化的血小板。3早期报告表明,EACA 可抑制补体系统第一组分的活化。4结合并灭活羧肽酶 B。5
Sigma Aldrich -  A9812 external link
包装
棕色螺纹盖样品瓶包装
Biochem/physiol Actions
赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。1,2据报告,EACA 可抑制纤溶酶原结合至活化的血小板。3早期报告表明,EACA 可抑制补体系统第一组分的活化。4结合并灭活羧肽酶 B。5
Sigma Aldrich -  A44606 external link
Application
止血剂。2,6用作赖氨酸类似物,用于表征纤溶酶原中的结合位点。7,8
Biochem/physiol Actions
赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。1,2据报告,EACA 可抑制纤溶酶原结合至活化的血小板。3早期报告表明,EACA 可抑制补体系统第一组分的活化。4结合并灭活羧肽酶 B。5
MP Biomedicals -  02101645 external link
Crystalline
A plasmin inhibitor.
Selleck Chemicals -  S1671 external link
Research Area: Cardiovascular Disease
Biological Activity:
Aminocaproic acid(Amicar) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that binds particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme is responsible for fibrinolysis. For this reason it is effective in treatment of certain bleeding disorders, especially fibrogenemia, and is marketed as Amicar. Aminocaproic acid is also an intermediate in the polymerization of Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam. [1]
Toronto Research Chemicals -  A609985 external link
6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in electrophoresis. Studies suggest that 6-Aminohexanoic Acid i

参考文献

参考文献

供应商提供 Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • Has been recommended as a reagent for the extraction of aldehydes from reaction mixtures, giving better recovery than bisulfite: Chem. Pharm. Bull., 28, 1917 (1980).
  • http://en.wikipedia.org/wiki/Aminocaproic_acid
  • Steffen, L.W., and Steffen, B.W., Clin. Chem. , 22 : 381, (1976).
  • Ohta ,S. et al.: Chem. Pharm. Bull., 28, 1917 (1980)
  • Shagger, H. et al.: Anal. Biochem., 199, 223 (1980)
  • Soter, N.A. et al.: J. Immunol., 114, 928 (1980)
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专利

专利

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