nitroso

• ChemBase编号: 318
• 分子式: NO
• 平均质量: 30.0061
• 单一同位素质量: 29.99798863
• SMILES: O=[N]
• Canonical SMILES: [N]=O
• InChI: InChI=1S/NO/c1-2
• InChIKey: MWUXSHHQAYIFBG-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: nitroso
• IUPAC系统名: Oxidonitrogen(?) (additive)
• IUPAC传统名: nitric oxide
• 商标名: Amidogen, oxo-; INOmax; Mononitrogen monoxide; NMO; NO; Nitric oxide 10% by volume or more; Nitric oxide trimer; Nitrogen monooxide; Nitrogen monoxide; Nitrogen oxide; Nitrosyl radical; RCRA waste number P076; nitrogen protoxide
• 别名: 氧化氮; 一氧化氮; Nitric Oxide; Nitric oxide; Nitrogen monoxide; Nitrogen(II) oxide

登记号

• CAS号: 10102-43-9
• EC号: 233-271-0
• MDL号: MFCD00011525
• PubChem SID: 160963781; 24857795; 46506897
• PubChem CID: 145068
• CHEBI ID: 16480
• ATC码: R07AX01
• CHEMBL: 1200689
• Chemspider ID: 127983
• DrugBank ID: DB00435
• Gmelin ID: 451
• KEGG ID: D00074
• 美国药典/FDA物质标识码: 31C4KY9ESH
• 维基百科标题: Nitric_oxide

理论计算性质

• 质子受体: 1
• 质子供体: 0
• LogD (pH = 5.5): -0.3514
• LogD (pH = 7.4): -0.3514
• Log P: -0.3514
• 摩尔折射率: 2.8858 cm^3
• 极化性: 1.69344 Å^3
• 极化表面积: 34.14 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: 74 cm^3 dm^-3 in water; 9.49E+004 mg/L
• 外观: Colourless gas
• 熔点: -163.6 °C(lit.); -164°C
• 沸点: -151.7 °C(lit.); -152°C
• 密度: 1.3402 g dm^-3
• 折射率: 1.0002697
• 蒸汽密度: 1.05 (vs air)
• 疏水性(logP): 0
• 标准摩尔生成焓 (ΔfH^o298): 90.29 kJ mol^-1
• 标准摩尔熵 (S^o298): 210.76 J K^-1 mol^-1

安全信息

• RTECS编号: QX0525000
• 欧盟危险性物质标志: 氧化性(Oxidising) (O); 有毒(Toxic) (T)
• 联合国危险货物编号: 1660
• 德国WGK号: 1
• 联合国危险货物等级: 2.3
• 危险公开号: 8-23-34-44; R8, R23, R34, R44
• 安全公开号: 17-23-36/37/39-45; S1, S17, S23, S36/37/39, S45
• GHS危险品标识: GHS03; GHS05; GHS06
• GHS警示词: Danger
• NFPA704:
  

  0

  3

  3

  OX
• GHS危险声明: H270-H314-H331
• GHS警示性声明: P220-P261-P280-P305 + P351 + P338-P310
• 个人保护装置: Faceshields, Gloves, Goggles, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• RID/ADR: UN 1660 2.3

药理学性质

• 给药途径: Inhalation
• 生物利用度: good
• 半衰期: 2–6 seconds
• 代谢: via pulmonary capillary bed

产品相关信息

• 纯度: 98.5%
• 线性分子式: NO

详细说明

DrugBank - DB00435

• Drug Groups: approved
• Description: Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.; ; Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant.; ; The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
• Indication: For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
• Pharmacology: Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia, sepsis, hyaline membrane disease, congenital diaphragmatic hernia (CDH), and pulmonary hypoplasia. In these states, pulmonary vascular resistance (PVR) is high, which results in hypoxemia secondary to right-to-left shunting of blood through the patent ductus arteriosus and foramen ovale. In neonates with PPHN, Nitric oxide improves oxygenation (as indicated by significant increases in PaO2). Nitric oxide appears to increase the partial pressure of arterial oxygen (PaO2) by dilating pulmonary vessels in better entilated areas of the lung, redistributing pulmonary blood flow away from lung regions with low ventilation/perfusion (V/Q) ratios toward regions with normal ratios.
• Affected Organisms: Humans and other mammals
• Biotransformation: via pulmonary capillary bed
• Absorption: Nitric oxide is absorbed systemically after inhalation.
• Half Life: 2–6 seconds
• Elimination: Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled.
• References: Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007 Jan;87(1):315-424. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

Sigma Aldrich - 295566

包装
17 L in steel cylinder
Recommended products
推荐使用不锈钢控制阀 Z146951、Z187224 或不锈钢调节器 Z148504 和 Z148512 中的任意一种，以及"T"型吹扫阀 Z151661。

参考文献

• Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007 Jan;87(1):315-424. Pubmed