您当前所在的位置:首页 > 产品中心 > 产品详细信息
608-73-1 分子结构
点击图片或这里关闭

1,2,3,4,5,6-hexachlorocyclohexane

ChemBase编号:314
分子式:C6H6Cl6
平均质量:290.82984
单一同位素质量:287.86006627
SMILES和InChIs

SMILES:
ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl
Canonical SMILES:
ClC1C(Cl)C(Cl)C(C(C1Cl)Cl)Cl
InChI:
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChIKey:
JLYXXMFPNIAWKQ-UHFFFAOYSA-N

引用这个纪录

CBID:314 http://www.chembase.cn/molecule-314.html

Collapse All Expand All

名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
1,2,3,4,5,6-hexachlorocyclohexane
IUPAC传统名
hexachlorocyclohexane
lindane
商标名
Aalindan
Aficide
Agrocide
Agrocide III
Agrocide WP
Ameisenmittel merck
Ameisentod
Aparasin
Aphtiria
Aplidal
Arbitex
Atlas steward
BBH
Ben-Hex
Bentox 10
Benzene hexachloride
Bexol
Celanex
Chloresene
Codechine
DBH
Detmol-Extrakt
Devoran
Dol Granule
Drilltox-Spezial Aglukon
Entomoxan
Esoderm
Fumite lindane
Gamacid
Gamene
Gamma-BHC dust
Gamma-Col
Gamma-HCH dust
Gammalin
Gammalin 20
Gammasan
Gammaterr
Gammexane
Gexane
HCCH
HCH
HGI
Heclotox
Hexa
Hexachloran
Hexachlorane
Hexachlorocyclohexane
Hexatox
Hexaverm
Hexicide
Hexit
Hexyclan
Hortex
Indane
Isotox
Jacutin
Kokotine
Kwell
Lendine
Lentox
Lidenal
Lindafor
Lindatox
Lindex
Lindosep
Lintox
Linvur
Lorexane
Milbol 49
Mszycol
Murfume grain store smoke
Neo-Scabicidol
New kotol
Nexen FB
Nexit
Nexit-Stark
Nexol-E
Nicochloran
Omnitox
Ovadziak
Owadziak
PMS Lindane
Pedraczak
Pflanzol
Quellada
Sang-«
gamma»
Scabene
Scabene lotion
Spritz-Rapidin
Spruehpflanzol
Streunex
TAP 85
Thionex
Tri-6
Viton
beta-BHC
beta-Hexachlorocyclohexane
beta-Lindane
别名
六六六
六六六
六六六(六氯环己烷的混合物)
Lindane
HCH
HCH
BHC (mixture of hexachlorocyclohexanes)
BENZENE HEXACHLORIDE
CAS号
608-73-1
58-89-9
EC号
206-270-8
200-401-2
MDL号
MFCD00003825
PubChem SID
160963777
24862770
PubChem CID
727

数据来源

数据来源

所有数据来源 商品来源 非商品来源

理论计算性质

理论计算性质

JChem ALOGPS 2.1
质子受体 质子供体
LogD (pH = 5.5) 4.3455415  LogD (pH = 7.4) 4.3455415 
Log P 4.3455415  摩尔折射率 54.081 cm3
极化性 22.464584 Å3 极化表面积 0.0 Å2
可自由旋转的化学键 里宾斯基五规则 true 
Log P 3.94  LOG S -4.73 
溶解度 5.47e-03 g/l 

分子性质

分子性质

理化性质 安全信息 产品相关信息 生物活性(PubChem)
溶解度
7.3 mg/L expand 查看数据来源
密度
1.85 g/ml expand 查看数据来源
疏水性(logP)
3.8 expand 查看数据来源
RTECS编号
GV3500000 expand 查看数据来源
GV4900000 expand 查看数据来源
欧盟危险性物质标志
环境危害性(Nature polluting) 环境危害性(Nature polluting) (N) expand 查看数据来源
有毒(Toxic) 有毒(Toxic) (T) expand 查看数据来源
联合国危险货物编号
2811 expand 查看数据来源
MSDS下载
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
德国WGK号
3 expand 查看数据来源
联合国危险货物等级
6.1 expand 查看数据来源
联合国危险货物包装类别(PG)
2 expand 查看数据来源
3 expand 查看数据来源
危险公开号
20/21-25-40-48/22-50/53-64 expand 查看数据来源
21-25-40-50/53 expand 查看数据来源
R:23/24/25-36/38-50/53 expand 查看数据来源
安全公开号
22-36/37-45-60-61 expand 查看数据来源
36/37-45-61 expand 查看数据来源
S:13-45-60-61 expand 查看数据来源
GHS危险品标识
GHS06 expand 查看数据来源
GHS08 expand 查看数据来源
GHS09 expand 查看数据来源
GHS警示词
Danger expand 查看数据来源
GHS危险声明
H301-H312-H351-H362-H373-H410 expand 查看数据来源
H301-H312-H351-H410 expand 查看数据来源
GHS警示性声明
P263-P273-P280-P301 + P310-P501 expand 查看数据来源
P273-P280-P301 + P310-P501 expand 查看数据来源
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges expand 查看数据来源
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges expand 查看数据来源
RID/ADR
UN 2811 6.1/PG 2 expand 查看数据来源
UN 2811 6.1/PG 3 expand 查看数据来源
级别
analytical standard expand 查看数据来源
PESTANAL®, analytical standard expand 查看数据来源
质检报告
下载链接 expand 查看数据来源
包装
ampule of 500 mg expand 查看数据来源
Empirical Formula (Hill Notation)
C6H6Cl6 expand 查看数据来源

详细说明

详细说明

MP Biomedicals MP Biomedicals DrugBank DrugBank Sigma Aldrich Sigma Aldrich
MP Biomedicals -  05204985 external link
MP Biomedicals Rare Chemical collection
DrugBank -  DB00431 external link
Item Information
Drug Groups approved
Description An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment.
Indication For the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies.
Pharmacology Scabies is a common, highly pruritic infestation of the skin caused by Sarcoptes scabiei (lice). It is a very contagious condition with specific lesions, such as burrows, and nonspecific lesions, such as papules, vesicles and excoriations. The typical areas of the body it affects are finger webs, scalp (hair), wrists, axillary folds, abdomen, buttocks, inframammary folds and genitalia (males). It is characterized by intense night-time itching. Scabies is spread through close personal contact (relatives, sexual partners, schoolchildren, chronically ill patients and crowded communities). Scabies infestations and the corresponding symptoms can be eliminated by killing the scabies with topical insecticides or scabicides. Lindane is a scabicide that is essentially an organochloride insecticide.
Toxicity Lindane is a moderately toxic compound via oral exposure, with a reported oral LD50 of 88 to 190 mg/kg in rats. Gamma-HCH (which constitutes 99% of lindane) is generally considered to be the most acutely toxic of the isomers following single administration. It is moderately toxic via the dermal route as well, with reported dermal LD50 values of 500 to 1000 mg/kg in rats, 300 mg/kg in mice, 400 mg/kg in guinea pigs, and 300 mg/kg in rabbits. Acute exposure to lindane may lead to central nervous system stimulation (usually developing within 1 hour), mental/motor impairment, excitation, clonic (intermittent) and tonic (continuous) convulsion. Other adverse reactions include central nervous system toxicity, as well as skin and gastrointestinal changes.
Affected Organisms
Scabies (Sarcoptes scabei) and other insects
Biotransformation Primarily hepatic through dechlorination leading to 2-chlorophenol, 0-chlorophenol, chlorocyclohexane, chlorocyclohexanol.
Absorption Lindane is absorbed significantly through the skin. A mean peak blood concentration of 28 nanograms per mL occurred in infants and children 6 hours after total body application of lindane lotion for scabies.
Half Life 18 hours
Protein Binding 91%
References
Brown VJ: Life after lindane in California. Environ Health Perspect. 2008 Mar;116(3):A128. [Pubmed]
Strong M, Johnstone PW: Interventions for treating scabies. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000320. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com
Sigma Aldrich -  36756 external link
法律信息
PESTANAL 注册商标 Sigma-Aldrich Laborchemikalien GmbH

参考文献

参考文献

供应商提供 Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • Strong M, Johnstone PW: Interventions for treating scabies. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000320. Pubmed
  • Brown VJ: Life after lindane in California. Environ Health Perspect. 2008 Mar;116(3):A128. Pubmed
正在搜索,请耐心等待...(如果遇到网页错误或者长时间没有结果,请刷新页面[F5])

专利

专利

PubChem iconPubChem Patent Google Patent Search IconGoogle Patent

互联网资源

互联网资源

百度图标百度 google iconGoogle