(5E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl]hept-5-enoic acid

• ChemBase编号: 312
• 分子式: C21H36O5
• 平均质量: 368.50754
• 单一同位素质量: 368.25627425
• SMILES: O[C@@H]1[C@@H]([C@H]([C@H](O)C1)/C=C/C(O)(CCCCC)C)C/C=C/CCCC(=O)O
• Canonical SMILES: CCCCCC(/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C/CCCC(=O)O)O)(O)C
• InChI: InChI=1S/C21H36O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5+,14-12+/t16-,17-,18+,19-,21+/m1/s1
• InChIKey: DLJKPYFALUEJCK-MRVZPHNRSA-N

名称和登记号

名称

• IUPAC标准名: (5E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl]hept-5-enoic acid
• IUPAC传统名: tham
• 商标名: Carboprost; Hemabate; Tham
• 别名: Carboprost Tromethamine

登记号

• CAS号: 58551-69-2
• PubChem SID: 160963775
• PubChem CID: 5284525

理论计算性质

JChem

• Acid pKa: 4.3552947
• 质子受体: 5
• 质子供体: 4
• LogD (pH = 5.5): 1.7186534
• LogD (pH = 7.4): -0.030425675
• Log P: 2.8916311
• 摩尔折射率: 105.1089 cm^3
• 极化性: 40.570885 Å^3
• 极化表面积: 97.99 Å^2
• 可自由旋转的化学键: 12
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: 4.29
• LOG S: -3.72
• 溶解度: 7.08e-02 g/l

分子性质

理化性质

• 溶解度: Carboprost tromethamine dissolves readily in water at room temperature at a concentration greater than 75 mg/mL.
• 疏水性(logP): 3.3

详细说明

DrugBank - DB00429

• Drug Groups: approved
• Description: A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy. [PubChem]
• Indication: For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
• Pharmacology: Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myome-trium has not been determined. Nonetheless, they evacuate the products of conception from the uterus in most cases. Postpartum, the resultant myometrial contractions provide hemostasis at the site of placentation. Carboprost tromethamine also stimulates the smooth muscle of the human gastrointestinal tract. This activity may produce the vomiting or diarrhea or both that is common when carbo-prost tromethamine is used to terminate pregnancy and for use postpartum. In laboratory animals and also in humans carboprost tromethamine can elevate body temperature. With the clinical doses of carboprost trometh-amine used for the termination of pregnancy, and for use postpartum, some patients do experience transient temperature increases. In laboratory animals and in humans large doses of carboprost tromethamine can raise blood pressure, probably by contracting the vascular smooth muscle. With the doses of carboprost tromethamine used for terminating pregnancy, this effect has not been clinically significant. In laboratory animals and also in humans carboprost tromethamine can elevate body temperature. With the clinical doses of carboprost tromethamine used for the termination of pregnancy, some patients do experience temperature increases. In some patients, carboprost tromethamine may cause transient bronchoconstriction.
• Toxicity: Symptoms of overdose include irritation, nausea, vomiting, diarrhea, coughing, dyspnea, asthma, hypertension, flushing, and pyrexia.
• Affected Organisms: Humans and other mammals
• Biotransformation: Metabolized in the lungs and liver. Metabolites are excreted in urine.
• External Links: RxList; Drugs.com