2-aminoacetic acid

• ChemBase编号: 31
• 分子式: C2H5NO2
• 平均质量: 75.0666
• 单一同位素质量: 75.03202841
• SMILES: OC(=O)CN
• Canonical SMILES: NCC(=O)O
• InChI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChIKey: DHMQDGOQFOQNFH-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 2-aminoacetic acid
• IUPAC传统名: glycine
• 商标名: Glycolixir; Glycosthene; Gyn-Hydralin; Padil; Aciport; Glicoamin; Glycocoll
• 别名: 甘氨酸, ACS; 乙氨酸; 氨基乙酸; 氨基醋酸; 甘氨酸; 甘氨酸; Glycine, ACS; Glycine-2-3H; Glycine; GLYCINE, ELECTROPHORESIS GRADE; Additive Screening Solution 47/Fluka kit no 78374; Glycine solution; Glycine 1 M solution; 2-Aminoacetic acid; Aminoacetic acid; Aminoethanoic acid; Gly; Glycine; Glycolixir; Hampshire Glycine; GLYCINE ACS REAGENT GRADE; 6-Aminopurine HCl; ADENINE HYDROCHLORIDE; Glycocoll; G; GLYCINE FREE ACID; GLYCINE, USP GRADE; Glycinum; Aciport; Glicoamin; Glycosthene; Gyn-Hydralin; H 1; NSC 25936; NSC 2916; NSC 54188; Padil; 2-Aminoacetic acid; H-Gly-OH

登记号

• CAS号: 21931-03-3; 6055-72-7; 56-40-6
• EC号: 231-791-2; 200-272-2
• MDL号: MFCD00135793; MFCD00008131
• Beilstein号: 635782
• 默克索引号: 144491
• PubChem SID: 46508219; 24849510; 24860042; 24873323; 24901611; 24895306; 24895210; 24895135; 160963494; 24895290; 24865701; 24895353; 24895355
• PubChem CID: 750
• CHEBI ID: 15428
• ATC码: B05CX03
• CHEMBL: 773
• Chemspider ID: 730
• DrugBank ID: DB00145
• FEMA编号: 3287
• IUPHAR配体索引: 727
• KEGG ID: D00011
• 美国药典/FDA物质标识码: TE7660XO1C
• 维基百科标题: Glycine
• 欧洲委员会编号: 4118
• Flavis Number: 17.034
• E编码: E640

理论计算性质

JChem

• Acid pKa: 2.307457
• 质子受体: 3
• 质子供体: 2
• LogD (pH = 5.5): -3.4094565
• LogD (pH = 7.4): -3.4150424
• Log P: -3.4094596
• 摩尔折射率: 16.0034 cm^3
• 极化性: 6.549665 Å^3
• 极化表面积: 63.32 Å^2
• 可自由旋转的化学键: 1
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: -3.34
• LOG S: 0.87
• 溶解度: 5.52e+02 g/l

分子性质

理化性质

• 溶解度: 1 M HCl: soluble1 M at 20 °C, clear, colorless; 1 M HCl: soluble1 M, clear; 1 M HCl: soluble1 M, clear, colorless; 1 M HCl: soluble75 mg/L, clear, colorless (2.252g in 30mL); 24.99 g/100 mL (25 °C) in water; 249 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; H2O: soluble100 mg/mL; hydrochloric acid: soluble1 M at 20 °C, clear; soluble in ethanol, pyridine ; insoluble in ether
• 外观: Crystalline; powder; Powder; white solid
• 熔点: ~250 °C (dec.); 182 °C; 233 °C (decomposition); 240 °C (dec.)(lit.); ca 245°C dec.
• 沸点: >= 233 °C with decomposition
• 密度: 1.03 g/mL at 20 °C; 1.16 g/ml; 1.595; 1.607 g/cm^3
• 紫外吸收波长: A1M/260, 1 M HCl ≤0.01; A1M/280 ≤0.15; A1M/280, 1 M HCl ≤0.01; λ: 260 nm Amax: 0.01; λ: 280 nm Amax: 0.01
• 疏水性(logP): -3.4
• pKa: 2.34 (carboxyl), 9.6 (amino); 2.35; 2.35 (25°C)
• 荧光: λex 200-600; λem 300-800 nm (corresponds)
• pH值: 5.9-6.4 (20 °C, 5%)
• 感官: sweet

安全信息

• 保存条件: Room Temperature (15-30°C)
• RTECS编号: MB7600000
• 欧盟危险性物质标志: R
• 联合国危险货物编号: 2910
• 德国WGK号: 1; 3
• 联合国危险货物等级: 7
• TSCA收录: 是
• 半数致死量: 2600 mg/kg (mouse, oral)
• 个人保护装置: Eyeshields, Gloves; Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RID/ADR: UN 2910 7
• 保存温度: 20-25°C; 2-8°C
• Regulation Compliance: FCC; FDA 21 CFR (170.50); FDA 21 CFR (172.320); FDA 21 CFR (172.812)

药理学性质

• 相关基因信息: rat ... Grin2a(24409)
• 过敏源: no known allergens

产品相关信息

• 纯度: ≥98.5%; ≥99%; ~99%; >99.5%; ≥98.5%; ≥98.5% (NT); ≥99%; ≥99% (titration); ≥99% (TLC); ≥99.0%; ≥99.0% (NT); 98%; 98.5+%; 99%; 99.5+%; 99.7-101% (calc. to the dried substance); 99-101% (based on anhydrous substance)
• 级别: ACS; ACS reagent; analytical standard; certified reference material; ELECTROPHORESIS; EP; for electrophoresis; for luminescence; for molecular biology; JP; NI; Ph Eur; PharmaGrade; puriss. p.a.; purum; Reag. Ph. Eur.; REAGENT; reagent grade; ReagentPlus®; SAJ special grade; TraceCERT®; USP
• 适用性: complies for appearance of solution; complies for reaction against H2SO4; in accordance for identity (IR); meets EP, JP, USP testing specifications; suitable for cell culture; suitable for manufacturing use
• 燃烧残渣: ≤0.05%; ≤0.05% (as SO4); ≤0.1%; ≤0.1% (as SO4)
• 杂质: ≤0.001% heavy metals (as Pb); ≤0.01% Ammonia; ≤0.01% Insoluble matter; ≤0.02% ammonium (NH4); ≤0.1% other ninhydrin-positive substances; ≤0.1% water (Karl Fischer); ≤0.3% foreign amino acids; ≤0.5% other ninhydrin-positive substances; 18.6%±0.2% total nitrogen acc. to Kjeldahl; DNases, none detected; endotoxin, tested; H2SO4, passes test(darkened); Hydrolyzable subsances, passes test; hydrolyzable substances, complies; Insoluble matter, passes filter test; insoluble matter, passes filter test; organic volatile impurities, complies (GC); phosphatases, none detected; proteases, none detected; residual solvents, complies; RNases, none detected
• 痕量阳离子: Al: ≤0.0005%; Al: ≤5 mg/kg; As: ≤0.00001%; As: ≤0.1 mg/kg; Ba: ≤0.0005%; Ba: ≤5 mg/kg; Bi: ≤0.0005%; Bi: ≤5 mg/kg; Ca: ≤0.001%; Ca: ≤10 mg/kg; Cd: ≤0.0005%; Cd: ≤5 mg/kg; Co: ≤0.0005%; Co: ≤5 mg/kg; Cr: ≤0.0005%; Cr: ≤5 mg/kg; Cu: ≤0.0005%; Cu: ≤5 mg/kg; Fe: ≤0.0005%; Fe: ≤5 mg/kg; heavy metals (as Pb): ≤0.002%; heavy metals (as Pb): ≤20 ppm; K: ≤0.005%; K: ≤50 mg/kg; Li: ≤0.0005%; Li: ≤5 mg/kg; Mg: ≤0.0005%; Mg: ≤5 mg/kg; Mn: ≤0.0005%; Mn: ≤5 mg/kg; Mo: ≤0.0005%; Mo: ≤5 mg/kg; Na: ≤0.005%; Na: ≤50 mg/kg; NH4+: ≤0.005%; NH4+: ≤0.02%; NH4+: ≤200 mg/kg; Ni: ≤0.0005%; Ni: ≤5 mg/kg; Pb: ≤0.0005%; Pb: ≤5 mg/kg; Sr: ≤0.0005%; Sr: ≤5 mg/kg; Zn: ≤0.0005%; Zn: ≤5 mg/kg
• 痕量阴离子: chloride (Cl-): ≤0.005%; chloride (Cl-): ≤30 mg/kg; chloride (Cl-): ≤50 mg/kg; chloride (Cl-): ≤70 ppm; sulfate (SO42-): ≤0.005%; sulfate (SO42-): ≤20 mg/kg; sulfate (SO42-): ≤50 mg/kg
• 生物来源: from non-animal source
• 干燥失重: ≤0.05% loss on drying; ≤0.05% loss on drying, 20 °C (HV); ≤0.05% loss on drying, 20°C (HV); ≤0.05% loss on drying, HV, 20 °C; ≤0.2% loss on drying; ≤0.2% loss on drying, 105 °C, 2 h; ≤0.2% loss on drying, 110 °C; ≤0.5% loss on drying, 105°C, 2 h
• 标签扩展内容: 30-60 Ci/mmol
• 产品质量级别: GMP-COMPENDIA
• 品质说明: meets analytical specification of Ph. Eur., BP, USP
• λ: 1 M in 1 M HCl
• 药典: testing & handling conforms to Pharmacopeia
• 产品线: BioUltra; BioXtra
• 线性分子式: NH2CH2COOH

详细说明

MP Biomedicals - 04808831

Electrophoresis Grade Purity: > 99.5% Heavy metals (as Pb): 20 ppm Used for preparation of Tris-glycine buffers.

MP Biomedicals - 02194049

ACS Reagent Grade
Purity: >98.5%
Heavy metals (as Pb): 20 ppm

MP Biomedicals - 02194681

Cell Culture Reagent
Crystalline
Free Acid

MP Biomedicals - 02100191

Crystalline

MP Biomedicals - 02194825

Molecular Biology Reagent Purity: 99+% Ideal for all molecular biology applications and buffer preparations.

MP Biomedicals - 02100570

Crystalline
Free Acid

MP Biomedicals - 04808822

Electrophoresis Grade
Purity: > 99.5%
Heavy metals (as Pb): 20 ppm
Used for preparation of Tris-glycine buffers.

MP Biomedicals - 02199462

USP Grade
White crystalline powder

DrugBank - DB00145

• Drug Groups: approved; nutraceutical
• Description: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem]
• Indication: Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.
• Pharmacology: Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.
• Toxicity: ORL-RAT LD₅₀ 7930 mg/kg, SCU-RAT LD₅₀ 5200 mg/kg, IVN-RAT LD₅₀ 2600 mg/kg, ORL-MUS LD₅₀ 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• Absorption: Absorbed from the small intestine via an active transport mechanism.
• External Links: Wikipedia; PDRhealth

Sigma Aldrich - G8790

Application
氨基酸可用于细胞培养基的研发以及现有培养基的配制。
Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - G7126

Biochem/physiol Actions
Glycine is a non-chiral amino acid that can be synthesized in the body from the amino acid serine by Serine Hydroxymethyltransferase.
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
包装
1 kg in poly bottle
10 mg in autosmp vl
100, 500 g in poly bottle
5, 25 kg in poly drum
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

Sigma Aldrich - G5417

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
包装
按照 cGMP 制造和包装

Sigma Aldrich - G3649

包装
serum bottle
Physical form
Aqueous solution containing 2% ethanol

Sigma Aldrich - 50046

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
Other Notes
Buffer component in the coupled phosphatase-kinase reaction for end labeling of restriction fragments1; Component of Tris-glycine reservoir buffer used in SDS-polyacrylamide gel electrophoresis in the characterization of in vitro translation products2.

Sigma Aldrich - 241261

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
包装
50 g in poly bottle

Sigma Aldrich - 94119

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - G8898

Analysis Note
经过检测，可用于 PAGE 电极缓冲液和蛋白质印迹转移缓冲液。
Application
甘氨酸是用于聚丙烯酰胺凝胶电泳的 Tris-甘氨酸和 Tris-甘氨酸-SDS 运行缓冲液的成分1。甘氨酸也是蛋白质印迹 Towbin 转移缓冲液的成分2。
Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 50056

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 74834

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - G7403

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 50049

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
Other Notes
Commonly used buffer substance in cryoenzymology1; For osmotic pressure maintenance in isoelectric focusing of erythrocytes2; In protein chemistry - salting-in effect3; Growth requirement of various microorganisms4.

Sigma Aldrich - 50052

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 50058

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 15527

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 410225

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
包装
50, 250 g in poly bottle

Sigma Aldrich - 76524

Analysis Note
该有证标准物质 (CRM) 根据 ISO/IEC 17025 和 ISO 指南 34 生产和认证。该有证标准物质可溯源到 NIST 标准参考物质。
Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
General description
证书上给出了含不确定度的认证含量（定量 NMR 法测定）和有效期。 证书下载：http://www.sigma-aldrich.com。
法律信息
TraceCERT 注册商标 Sigma-Aldrich Co. LLC

Sigma Aldrich - G6201

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - W328707

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。
包装
1 kg in poly bottle
1 sample in glass bottle
10, 25 kg in fiber drum

Sigma Aldrich - 12-1210

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 50050

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Sigma Aldrich - 33226

Biochem/physiol Actions
脊髓中的抑制性神经递质，NMDA 受体的变构调节剂。

Toronto Research Chemicals - G615990

Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

参考文献

• Scott, D., et al.: J. Neurosci., 21, 3063 (2001)
• Laube, B., et al.: Neuropharmacology, 47, 994 (2001)
• Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2001)
• Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2001)
• Wolosker, H., et al.: Mol. Neurobiol., 36