dimethyl[3-(10H-phenothiazin-10-yl)propyl]amine

• ChemBase编号: 303
• 分子式: C17H20N2S
• 平均质量: 284.4191
• 单一同位素质量: 284.13471965
• SMILES: S1c2c(N(CCCN(C)C)c3c1cccc3)cccc2
• Canonical SMILES: CN(CCCN1c2ccccc2Sc2c1cccc2)C
• InChI: InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
• InChIKey: ZGUGWUXLJSTTMA-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: dimethyl[3-(10H-phenothiazin-10-yl)propyl]amine
• IUPAC传统名: promazine
• 商标名: AB; Aminazin; Aminazine; Ampazine; Ampliactil; Amplictil; Berophen; Chlor-Promanyl; Chlordelazin; Chlorderazin; Chlorpromados; Chlorpromazine Hcl Intensol; Chlropromados; Contomin; Elmarin; Esmind; Esparin; Fenactil; Fenaktyl; Fraction; Largactil; Largactilothiazine; Largactyl; Liranol; Megaphen; Neo-Hibernex; Novomazina; Phenactyl; Prazin; Prazine; Proma; Promactil; Promapar; Promazil; Promwill; Propaphenin; Protactyl; Prozil; Psychozine; Romtiazin; Sanopron; Sinophenin; Sonazine; Sparine; Thorazine; Torazina; Verophen; Vesprin; Wintermin
• 别名: Chlorpromazine Hcl; CPZ; Phenothiazine; Promazine Hcl; Promazina; Promazin; Promazine

登记号

• CAS号: 58-40-2
• PubChem SID: 46504504; 160963766
• PubChem CID: 4926
• CHEBI ID: 8459
• ATC码: N05AA03
• CHEMBL: 564
• Chemspider ID: 4757
• DrugBank ID: DB00420
• 美国药典/FDA物质标识码: O9M39HTM5W
• 维基百科标题: Promazine
• Medline Plus: a600010

理论计算性质

JChem

• 质子受体: 2
• 质子供体: 0
• LogD (pH = 5.5): 0.6436315
• LogD (pH = 7.4): 2.1355963
• Log P: 3.9309556
• 摩尔折射率: 88.9515 cm^3
• 极化性: 34.1545 Å^3
• 极化表面积: 6.48 Å^2
• 可自由旋转的化学键: 4
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: 4.63
• LOG S: -4.14
• 溶解度: 2.07e-02 g/l

分子性质

理化性质

• 溶解度: 14.2 mg/L
• 疏水性(logP): 4.3

药理学性质

• 蛋白结合率: 94%

详细说明

DrugBank - DB00420

• Drug Groups: approved
• Description: A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. [PubChem]
• Indication: Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
• Pharmacology: Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
• Toxicity: Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic, primarily to N-desmethylpromazine and promazine sulfoxide.
• Absorption: Absorption may be erratic and peak plasma concentrations show large interindividual differences.
• Protein Binding: 94%
• External Links: Wikipedia