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2,2-dichloro-N-[(2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide

ChemBase编号:179844
分子式:C11H12Cl2N2O5
平均质量:323.12938
单一同位素质量:322.01232685
SMILES和InChIs

SMILES:
[N+](=O)(c1ccc(C([C@H](NC(=O)C(Cl)Cl)CO)O)cc1)[O-]
Canonical SMILES:
OC[C@H](C(c1ccc(cc1)[N+](=O)[O-])O)NC(=O)C(Cl)Cl
InChI:
InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9?/m1/s1
InChIKey:
WIIZWVCIJKGZOK-VEDVMXKPSA-N

引用这个纪录

CBID:179844 http://www.chembase.cn/molecule-179844.html

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名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
2,2-dichloro-N-[(2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
IUPAC传统名
2,2-dichloro-N-[(2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
别名
Alficetyn
Chemicetin
Chlorcetin
Chlorocid
Chlorocidin C
Chloromycetin
Chloronitrin
Chloroptic
Detreomycin
Enteromycetin
Flamycin
Gloveticol
Halcetin
Kemicetine
Levomycetin
Normimycin V
Ophthochlor
Paraxin
Sintomicetin
Synthomycin
Umimycin
Chloramphenicol
CAS号
56-75-7
PubChem SID
164235754
PubChem CID
16399516

数据来源

数据来源

所有数据来源 商品来源 非商品来源
数据来源 数据ID 价格
InterBioScreen
Bio-0639 external link 加入购物车 请登录
数据来源 数据ID
PubChem 16399516 external link

理论计算性质

理论计算性质

JChem
Acid pKa 7.4943175  质子受体
质子供体 LogD (pH = 5.5) 0.87482697 
LogD (pH = 7.4) 0.66041094  Log P 0.8787035 
摩尔折射率 73.2007 cm3 极化性 27.817905 Å3
极化表面积 115.38 Å2 可自由旋转的化学键
里宾斯基五规则 true 

分子性质

分子性质

药理学性质 产品相关信息 生物活性(PubChem)
生物活性机理
Interferes with transfer of activated aminoacids from soluble RNA to ribosomes expand 查看数据来源
Protein synthesis inhibitor expand 查看数据来源
生物来源
Metab. of the fungus Acrodontium salmoneum expand 查看数据来源
应用领域
Antibiotic expand 查看数据来源

详细说明

详细说明

参考文献

参考文献

供应商提供 Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
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  • Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1380A, (nmr)
  • Long, L.M. et al., J.A.C.S., 1949, 71, 2473, (synth)
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  • IARC Monog., 1976, 10, 85; Suppl. 6, 142; Suppl. 7, 145, (tox, rev)
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  • Pongs, O. et al., Antibiotics (N.Y.), 1979, 5, 26, (rev)
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  • Hazra, B.G. et al., Synth. Commun., 1989, 19, 1763, (synth)
  • Chenevert, R. et al., Synthesis, 1989, 444, (synth, pmr)
  • Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 961, (rev)
  • Rao, A.V.R. et al., Chem. Comm., 1992, 859, (synth)
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  • Merck Index, 12th edn., 1996, No. 2120
  • Hazra, B.G. et al., Synth. Commun., 1997, 27, 1857-1864, (synth)
  • Corey, E.J. et al., Tet. Lett., 2000, 41, 2765-2768, (synth)
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  • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CDP250; CDP700
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专利

专利

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