N-(4-aminobenzenesulfonyl)acetamide hydrate sodium

• ChemBase编号: 155424
• 分子式: C8H12N2NaO4S
• 平均质量: 255.24665
• 单一同位素质量: 255.04154716
• SMILES: CC(=O)NS(=O)(=O)c1ccc(cc1)N.O.[Na]
• Canonical SMILES: CC(=O)NS(=O)(=O)c1ccc(cc1)N.O.[Na]
• InChI: InChI=1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2
• InChIKey: UPEPDWDCUMJQBS-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: N-(4-aminobenzenesulfonyl)acetamide hydrate sodium
• IUPAC传统名: sulfacetamide hydrate sodium
• 别名: N-(p-Aminobenzenesulfonyl)acetamide; Sulfacetamide sodium salt

登记号

• CAS号: 6209-17-2
• MDL号: MFCD00007885
• PubChem SID: 162249562; 24899806
• PubChem CID: 16219986

理论计算性质

• Acid pKa: 4.2999835
• 质子受体: 4
• 质子供体: 2
• LogD (pH = 5.5): -1.0395306
• LogD (pH = 7.4): -1.2013199
• Log P: -0.26104107
• 摩尔折射率: 52.4822 cm^3
• 极化性: 20.56703 Å^3
• 极化表面积: 89.26 Å^2
• 可自由旋转的化学键: 1
• 里宾斯基五规则: true

分子性质

安全信息

• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品相关信息

• 线性分子式: C8H9N2O3SNa

详细说明

Sigma Aldrich - S8647

Application
Sulfacetamide is an antibiotic that is used to treat skin infections and urinary tract infections1. Sulfacetamide is used to study the treatment of acne and seborrheic dermatitis. It is used to study neonatal chlamydial conjunctivitis and meningococcal conjunctivitis.
Biochem/physiol Actions
Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.