octahydropyrrolo[1,2-a]piperazine-1,4-dione

• ChemBase编号: 154564
• 分子式: C7H10N2O2
• 平均质量: 154.1665
• 单一同位素质量: 154.07422757
• SMILES: C1CC2C(=O)NCC(=O)N2C1
• Canonical SMILES: O=C1CNC(=O)C2N1CCC2
• InChI: InChI=1S/C7H10N2O2/c10-6-4-8-7(11)5-2-1-3-9(5)6/h5H,1-4H2,(H,8,11)
• InChIKey: OWOHLURDBZHNGG-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: octahydropyrrolo[1,2-a]piperazine-1,4-dione
• IUPAC传统名: hexahydropyrrolo[1,2-a]piperazine-1,4-dione
• 别名: (S)-3,6-Dioxohexahydropyrrolo[1,2-a]pyrazine; Glycyl-L-proline lactam; cyclo-Glycyl-L-Proline; cyclo-L-prolylglycine; cyclo-GP; Cyclo-Gly-Pro; octahydropyrrolo[1,2-a]piperazine-1,4-dione

登记号

• CAS号: 3705-27-9
• MDL号: MFCD01083707
• PubChem SID: 162248702
• PubChem CID: 193540

理论计算性质

• Acid pKa: 11.351039
• 质子受体: 2
• 质子供体: 1
• LogD (pH = 5.5): -1.3691372
• LogD (pH = 7.4): -1.3691797
• Log P: -1.3691367
• 摩尔折射率: 37.79 cm^3
• 极化性: 14.663719 Å^3
• 极化表面积: 49.41 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: DMSO: >10 mg/mL
• 外观: powder
• 疏水性(logP): -0.822

安全信息

• 德国WGK号: 3
• 保存温度: -20°C

产品相关信息

• 纯度: ≥98% (GC/HPLC); 95%
• Empirical Formula (Hill Notation): C7H10N2O2

详细说明

Sigma Aldrich - C2374

Biochem/physiol Actions
Cyclo-Gly-Pro is a neuro-protective compound, an endogenous diketopiperazine, which enhances memory. In the animal model of PD, the compound improved functional recovery when administered after the onset of dyskinesia. It appears that the compound recovery function may result from non-proliferative neurogenesis that results from the inhibition of apoptosis of stem cells and/or the promotion of neuronal-orientated proliferation in the SVZ (subventricular zone).