[2-(2,3-dihydro-1,4-benzodioxin-6-yloxy)ethyl]dimethylamine hydrochloride

• ChemBase编号: 154359
• 分子式: C12H18ClNO3
• 平均质量: 259.72922
• 单一同位素质量: 259.09752112
• SMILES: CN(C)CCOc1ccc2c(c1)OCCO2.Cl
• Canonical SMILES: CN(CCOc1ccc2c(c1)OCCO2)C.Cl
• InChI: InChI=1S/C12H17NO3.ClH/c1-13(2)5-6-14-10-3-4-11-12(9-10)16-8-7-15-11;/h3-4,9H,5-8H2,1-2H3;1H
• InChIKey: VRCSNYKNBODDIM-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: [2-(2,3-dihydro-1,4-benzodioxin-6-yloxy)ethyl]dimethylamine hydrochloride
• IUPAC传统名: [2-(2,3-dihydro-1,4-benzodioxin-6-yloxy)ethyl]dimethylamine hydrochloride
• 别名: p30

登记号

• MDL号: MFCD01727216
• PubChem SID: 162248498
• PubChem CID: 71311847

理论计算性质

• 质子受体: 4
• 质子供体: 0
• LogD (pH = 5.5): -1.7281688
• LogD (pH = 7.4): -0.046478506
• Log P: 1.3473516
• 摩尔折射率: 61.4977 cm^3
• 极化性: 24.205555 Å^3
• 极化表面积: 30.93 Å^2
• 可自由旋转的化学键: 4
• 里宾斯基五规则: true

分子性质

安全信息

• 欧盟危险性物质标志: B
• 德国WGK号: 1
• 安全公开号: 23-24/25
• 保存温度: -20°C

详细说明

Sigma Aldrich - P1246

Preparation Note
Expressed as a GST fusion protein.
Unit Definition
One unit will incorporate 1 picomole of phosphate into histone H1 peptide per minute at pH 7.2 at 30 °C.
Physical form
p30 is supplied in a solution of 25 mM Tris, pH 7.4, 1 mM DTT, and 30% glycerol. (0.5 μg protein/ 25 ul vial)
Application
p30 is an endogenous truncated form of p39 that associates with Cdk5 to form Nclk, which regulates neurotransmission, axon guidance, central nervous system (CNS) architecture, and pathogenesis. Therefore, p30 is useful in studying neurodegenerative diseases such as Alzheimer’s, Amyotrophic Lateral Sclerosis, and Parkinson’s Disease.
Biochem/physiol Actions
P30 activates GST-Neuronal cyclin-dependent kinase 5 (Cdk5). It also associates with Cdk5 to form an activated neuronal Cdc2-like kinase (Nclk). Product P1246 is recombinant, from bovine and is expressed in E. coli.