8-{2-[(2-pentylcyclopropyl)methyl]cyclopropyl}octanoic acid

• ChemBase编号: 153851
• 分子式: C20H36O2
• 平均质量: 308.49864
• 单一同位素质量: 308.27153039
• SMILES: CCCCCC1CC1CC1CC1CCCCCCCC(=O)O
• Canonical SMILES: CCCCCC1CC1CC1CC1CCCCCCCC(=O)O
• InChI: InChI=1S/C20H36O2/c1-2-3-7-10-16-13-18(16)15-19-14-17(19)11-8-5-4-6-9-12-20(21)22/h16-19H,2-15H2,1H3,(H,21,22)
• InChIKey: CONYTTFKIUJZOF-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 8-{2-[(2-pentylcyclopropyl)methyl]cyclopropyl}octanoic acid
• IUPAC传统名: 8-{2-[(2-pentylcyclopropyl)methyl]cyclopropyl}octanoic acid
• 别名: 2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid; 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid; FR 236924; DCP-LA

登记号

• CAS号: 28399-31-7
• MDL号: MFCD09265251
• PubChem SID: 162247990; 24724463
• PubChem CID: 9904718

理论计算性质

• Acid pKa: 4.7217865
• 质子受体: 2
• 质子供体: 1
• LogD (pH = 5.5): 5.6328254
• LogD (pH = 7.4): 3.8553112
• Log P: 6.477207
• 摩尔折射率: 91.6736 cm^3
• 极化性: 36.62372 Å^3
• 极化表面积: 37.3 Å^2
• 可自由旋转的化学键: 14
• 里宾斯基五规则: false

分子性质

理化性质

• 溶解度: DMSO: >2 mg/mL
• 外观: clear oil

安全信息

• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥95% (HPLC)
• Empirical Formula (Hill Notation): C20H36O2

详细说明

Sigma Aldrich - D5318

Biochem/physiol Actions
DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.