您当前所在的位置:首页 > 产品中心 > 产品详细信息
68-39-3 分子结构
点击图片或这里关闭

4-amino-1,2-oxazolidin-3-one

ChemBase编号:145
分子式:C3H6N2O2
平均质量:102.09194
单一同位素质量:102.04292744
SMILES和InChIs

SMILES:
O1NC(=O)C(N)C1
Canonical SMILES:
NC1CONC1=O
InChI:
InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)
InChIKey:
DYDCUQKUCUHJBH-UHFFFAOYSA-N

引用这个纪录

CBID:145 http://www.chembase.cn/molecule-145.html

Collapse All Expand All

名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
4-amino-1,2-oxazolidin-3-one
IUPAC传统名
DL-cycloserine
(+-)-4-amino-3-isoxazolidinone
商标名
Closerin
Closina
Cyclomycin
Cyclorin
Cycloserin
Farmiserina
Farmiserine
Micoserina
Miroserina
Miroseryn
Novoserin
Orientomycin
Oxamicina
Oxamycin
Oxymycin
Seromycin
Tebemicina
Tisomycin
Wasserina
别名
4-氨基-3-异噁唑烷酮
DL-环丝氨酸
D-环丝氨酸
4-Amino-3-isoxazolidone
DL-Cycloserine
4-Amino-3-isoxazolidinone
(R)-(+)-4-Amino-3-isoxazolidinone
D-Cycloserine
D-Cycloserine
(+/-)-3-Oxoisooxazolidin-4-amine
rac Cycloserine
4-amino-1,2-oxazolidin-3-one
4-Aminoisoxazolidin-3-one
alpha-Cycloserine
Cicloserina
D-CS
D-Cycloserine
D-Cycloserine synth. BP 88
D-Cycloserine, synthetic
D-Oxamicina
D-Oxamycin
DL-Cycloserine
L-Cycloserine
Cycloserine
CAS号
68-39-3
68-41-7
EC号
200-688-4
200-687-9
MDL号
MFCD00005353
MFCD00064323
Beilstein号
80798
默克索引号
142751
PubChem SID
24278332
160963608
PubChem CID
401

理论计算性质

理论计算性质

JChem ALOGPS 2.1
Acid pKa 4.210087  质子受体
质子供体 LogD (pH = 5.5) -2.4357781 
LogD (pH = 7.4) -2.4206417  Log P -2.4213324 
摩尔折射率 21.8488 cm3 极化性 9.062646 Å3
极化表面积 64.35 Å2 可自由旋转的化学键
里宾斯基五规则 true 
Log P -2.31  LOG S 0.93 
溶解度 8.77e+02 g/l 

分子性质

分子性质

理化性质 安全信息 药理学性质 产品相关信息 生物活性(PubChem)
溶解度
Soluble expand 查看数据来源
Soluble in water. Slightly soluble in methanol, propylene glycol. expand 查看数据来源
Water expand 查看数据来源
外观
crystalline expand 查看数据来源
Off-White Solid expand 查看数据来源
熔点
>183°C (dec.) expand 查看数据来源
137°C dec. expand 查看数据来源
比旋光度
+115 (c=2 in water) expand 查看数据来源
疏水性(logP)
-0.9 expand 查看数据来源
-1.192 expand 查看数据来源
保存条件
Refrigerator expand 查看数据来源
保存注意事项
Air Sensitive expand 查看数据来源
RTECS编号
NY2974900 expand 查看数据来源
NY2975000 expand 查看数据来源
MSDS下载
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
德国WGK号
3 expand 查看数据来源
TSCA收录
expand 查看数据来源
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter expand 查看数据来源
保存温度
-20°C expand 查看数据来源
相关基因信息
human ... GPT(2875), GPT2(84706) expand 查看数据来源
纯度
95% expand 查看数据来源
95+% expand 查看数据来源
97% expand 查看数据来源
98% expand 查看数据来源
98+% expand 查看数据来源
质检报告
下载链接 expand 查看数据来源
Empirical Formula (Hill Notation)
C3H6N2O2 expand 查看数据来源

详细说明

详细说明

DrugBank DrugBank Sigma Aldrich Sigma Aldrich TRC TRC
DrugBank -  DB00260 external link
Item Information
Drug Groups approved
Description Antibiotic substance produced by Streptomyces garyphalus. [PubChem]
Indication Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
Pharmacology Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Cycloserine works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria
Toxicity Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.
Half Life Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.
External Links
Wikipedia
Drugs.com
Sigma Aldrich -  C7005 external link
Biochem/physiol Actions
Inhibitor of alanine aminotransferase and other pyridoxal-phosphate-requiring transaminases1; blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase.
Sigma Aldrich -  862002 external link
Biochem/physiol Actions
Inhibitor of alanine aminotransferase and other pyridoxal-phosphate-requiring transaminases1; blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase.
Toronto Research Chemicals -  C988800 external link
Antibacterial (tuberculostatic).

参考文献

参考文献

供应商提供 Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • Lamb., J.W., et al.: Anal. Profiles Drug Subs., 1, 53 (1972)
  • Gentry-Weeks, C., et al.: J. Biol. Chem., 268, 7298 (1972)
  • Alexander, F., et al.: Eur. J. Biochem., 219, 953 (1972)
  • Auger, S., et al.: Biochimie, 87, 231 (1972)
正在搜索,请耐心等待...(如果遇到网页错误或者长时间没有结果,请刷新页面[F5])

专利

专利

PubChem iconPubChem Patent Google Patent Search IconGoogle Patent

互联网资源

互联网资源

百度图标百度 google iconGoogle