1,3-dithiane

• ChemBase编号: 137582
• 分子式: C4H8S2
• 平均质量: 120.23632
• 单一同位素质量: 120.00674226
• SMILES: C1CSCSC1
• Canonical SMILES: C1CCSCS1
• InChI: InChI=1S/C4H8S2/c1-2-5-4-6-3-1/h1-4H2
• InChIKey: WQADWIOXOXRPLN-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 1,3-dithiane
• IUPAC传统名: 1,3-dithiane
• 别名: 1,3-二噻烷; 1,3-Dithiane; 1,3-Dithiane

登记号

• CAS号: 505-23-7
• EC号: 208-006-7
• MDL号: MFCD00006654
• Beilstein号: 102534
• PubChem SID: 24849705; 162231844; 24867374
• PubChem CID: 10451

理论计算性质

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): 1.498092
• LogD (pH = 7.4): 1.498092
• Log P: 1.498092
• 摩尔折射率: 34.0023 cm^3
• 极化性: 13.498343 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 熔点: 52-54 °C; 52-54 °C(lit.); 52-55°C
• 沸点: 207-208°C
• 闪点: 194 °F; 90 °C; 90°C(194°F)

安全信息

• RTECS编号: JO5070000
• 联合国危险货物编号: UN3335
• 德国WGK号: 3
• 联合国危险货物等级: 9
• 联合国危险货物包装类别(PG): III
• TSCA收录: 否
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品相关信息

• 纯度: ≥97.0% (GC); 97%; 98%
• 级别: purum
• Empirical Formula (Hill Notation): C4H8S2

详细说明

Sigma Aldrich - 157872

包装
1, 5, 25, 100 g in glass bottle

Sigma Aldrich - 43745

Other Notes
综述1,2

参考文献

• Chloramine-T: Synth. Commun., 2, 7 (1972); NCS, AgNO₃, acetonitrile-water: J. Org. Chem., 36, 3553 (1971); 48, 1552 (1983); SO₂Cl₂, silica, DCM-water: Synthesis, 678 (1976); Bromodimethylsulfonium bromide (from DMSO and bromine): Synthesis, 720 (1979); DMSO-HCl-dioxane: Synthesis, 679 (1982); CuCl₂, CuO, acetone: Org. Synth. Coll., 6, 109 (1988); CAN, acetonitrile-water: Synth. Commun., 11, 423 (1981); DDQ, acetonitrile-water: J. Chem. Soc., Perkin 1, 453 (1996); Phenyl phosphorodichloridate, NaI, acetonitrile-DMF: Tetrahedron Lett., 29, 5471 (1988); Glyoxylic acid in AcOH: Synthesis, 694 (1976); HIO₄, THF-ether: Tetrahedron Lett., 37, 4331 (1996); PhI(OAc)₂, acetone-water: Syn. Commun., 30, 4081 (2000). For facilitation of cleavage of 1,3-dithianes by S-alkylation, see Trimethyloxonium tetrafluoroborate, A15175.
• The 2-lithio derivative, normally generated with n-BuLi, behaves as a formyl anion equivalent. It has been shown that the rigorous exclusion of atmospheric oxygen minimizes side reactions and is critical in obtaining optimum results in these lithiation procedures: J. Org. Chem., 60, 4258 (1995).
• Monoalkylation of the 2-lithio-derivative and cleavage of the dithiane leads to an aldehyde. Successive dialkylation provides a route to ketones. For reviews of the reversal of the normal reactivity of groups, "umpolung", see: Angew. Chem. Int. Ed., 18, 239 (1979), and of the umpolung of carbonyl activity through sulfur-containing reagents: Synthesis, 357 (1977). See also 1,3-Propanedithiol, A15261, 1,3-Dithiolane, L11914, and 1,2-Ethanedithiol, L12865.
• Reaction with 2-cyclohexenone proceeds via 1,2-addition. For details of this and subsequent cleavage and rearrangement, see: Org. Synth. Coll., 8, 309 (1993):
  
• For conversion to the dithienium salt by hydride abstraction, see Triphenylcarbenium tetrafluoroborate, A12949.
• Reviews: Synthetic uses of 1,3-dithianes: Tetrahedron, 45, 7643 (1989); Chemistry of 1,3-dithioacetals: Organosulfur Chemistry, P. Page, Ed., Academic Press N.Y. (1995).
• For an example of successive acylation and alkylation of 1,3-dithiane, which can be carried out as a one-pot sequence, see: Synthesis, 625 (1980).
• Cleavage of 1,3-dithianes has been effected by a variety of methods, including: