4-[(2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid sodium

• ChemBase编号: 133661
• 分子式: C15H16Cl2N2NaO8
• 平均质量: 446.19191
• 单一同位素质量: 445.01814012
• SMILES: c1cc(ccc1[C@H]([C@@H](COC(=O)CCC(=O)O)NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na]
• Canonical SMILES: OC(=O)CCC(=O)OC[C@H]([C@@H](c1ccc(cc1)[N+](=O)[O-])O)NC(=O)C(Cl)Cl.[Na]
• InChI: InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/t10-,13-;/m1./s1
• InChIKey: OQAWGHRXAVKAIG-HTMVYDOJSA-N

名称和登记号

名称

• IUPAC标准名: 4-[(2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid sodium
• IUPAC传统名: chloramphenicol succinate sodium
• 别名: Chloramphenicol α-succinate; Chloramphenicol succinate sodium salt

登记号

• CAS号: 982-57-0
• EC号: 213-568-1
• MDL号: MFCD00079025
• PubChem SID: 162227938; 24892643
• PubChem CID: 16219114

理论计算性质

• Acid pKa: 3.6750705
• 质子受体: 7
• 质子供体: 3
• LogD (pH = 5.5): -0.6805518
• LogD (pH = 7.4): -2.3224185
• Log P: 1.1446916
• 摩尔折射率: 93.2455 cm^3
• 极化性: 36.007523 Å^3
• 极化表面积: 158.75 Å^2
• 可自由旋转的化学键: 11
• 里宾斯基五规则: true

分子性质

安全信息

• RTECS编号: AB6905000
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 德国WGK号: 3
• 危险公开号: 40
• 安全公开号: 22-36
• GHS危险品标识: GHS08
• GHS警示词: Warning
• GHS危险声明: H351
• GHS警示性声明: P281
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品相关信息

• 纯度: ≥80% (HPLC)

详细说明

Sigma Aldrich - C3787

Application
Chloramphenicol is used as a selection agent for transformed cells containing a chloramphenicol resistance gene and is used to halt protein synthesis 1.
Biochem/physiol Actions
Chloramphenicol inhibits bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. Used as a selection agent for transformed cells containing a chloramphenicol resistance gene.
Chloramphenicol inhibits bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit.