({[({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid sodium

• ChemBase编号: 133291
• 分子式: C9H15N2NaO14P3
• 平均质量: 491.131453
• 单一同位素质量: 490.96338234
• SMILES: c1cn(c(=O)[nH]c1=O)C1CC(C(O1)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O.[Na]
• Canonical SMILES: OC1CC(OC1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1ccc(=O)[nH]c1=O.[Na]
• InChI: InChI=1S/C9H15N2O14P3.Na/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)
• InChIKey: ISKGXNFLJOMAKE-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: ({[({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid sodium
• IUPAC传统名: deoxyuridine-5'-triphosphate sodium
• 别名: dUTP 钠盐; 2′-脱氧尿苷 5′-三磷酸 钠盐 溶液; 2′-脱氧尿苷 5′-三磷酸 钠盐; 2′-Deoxyuridine 5′-triphosphate sodium salt solution; 2′-Deoxyuridine 5′-triphosphate sodium salt

登记号

• CAS号: 102814-08-4; 94736-09-1
• MDL号: MFCD01630759; MFCD00084701
• PubChem SID: 24893804; 24893218; 162227568
• PubChem CID: 16219193

理论计算性质

• Acid pKa: 0.89528304
• 质子受体: 11
• 质子供体: 6
• LogD (pH = 5.5): -9.158568
• LogD (pH = 7.4): -9.894156
• Log P: -2.4817672
• 摩尔折射率: 83.6736 cm^3
• 极化性: 34.385967 Å^3
• 极化表面积: 238.69 Å^2
• 可自由旋转的化学键: 8
• 里宾斯基五规则: false

分子性质

安全信息

• 德国WGK号: 1
• 保存温度: -20°C

产品相关信息

• 纯度: ~95%; ≥99%
• 浓度: 100 mM in H2O
• Foreign Activity: DNase, RNase, none detected
• 运输包装: dry ice

详细说明

Sigma Aldrich - D4001

Application
2′-Deoxyuridine 5′-triphosphate (dUTP) may be used to study the distribution, specificity and kinetics of deoxyuridine 5′-triphosphate nucleotidohydrolase(s) (dUTPase, EC 3.6.1.23). dUTPase are important enzymes that protect cells from the incorporation of dUTP into DNA.dUTP is a component of the TUNEL (terminal deoxyribonucleotidyl-transferase-(TdT)-mediated deoxyuridine-5′-triphosphate- (dUTP) nick-end labeling) test. TUNEL is a common method for detecting DNA fragmentation that results from apoptotic signaling cascades.

Sigma Aldrich - D0184

Application
在 PCR 中与尿嘧啶 DNA 糖基化酶联用以防遗留污染。在 PCR 反应中，用 dUTP 代替 dTTP。