(2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(4R,5S,6S,7R,9R,11Z,13Z,15R,16R)-6-{[(2R,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-15-({[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}methyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde

• ChemBase编号: 132528
• 分子式: C50H83NO23
• 平均质量: 1066.18692
• 单一同位素质量: 1065.53558792
• SMILES: CC[C@@H]1[C@H](/C=C(\C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C)O[C@H]1C[C@@]([C@H]([C@@H](O1)C)O)(C)O)N(C)C)O)CC=O)C)/C)CO[C@H]1[C@@H]([C@@H]([C@@H]([C@H](O1)C)O)OC)OC.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
• Canonical SMILES: OC(=O)[C@@H]([C@H](C(=O)O)O)O.O=CC[C@H]1C[C@@H](C)C(=O)/C=C\C(=C/[C@@H]([C@H](OC(=O)C[C@H]([C@@H]([C@H]1O[C@@H]1O[C@H](C)[C@H]([C@@H]([C@H]1O)N(C)C)O[C@@H]1O[C@@H](C)[C@@H]([C@](C1)(C)O)O)C)O)CC)CO[C@@H]1O[C@H](C)[C@H]([C@H]([C@H]1OC)OC)O)\C
• InChI: InChI=1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14-,23-18-;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
• InChIKey: ICVKYYINQHWDLM-YOMZPPEJSA-N

名称和登记号

名称

• IUPAC标准名: (2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(4R,5S,6S,7R,9R,11Z,13Z,15R,16R)-6-{[(2R,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-15-({[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}methyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
• IUPAC传统名: 2-[(4R,5S,6S,7R,9R,11Z,13Z,15R,16R)-6-{[(2R,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-15-({[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}methyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde; L(+)-tartaric acid
• 别名: 泰乐菌素 酒石酸酯; 泰乐菌素 溶液; Tylosin tartrate; Tylosin solution

登记号

• CAS号: 74610-55-2
• MDL号: MFCD07783824
• PubChem SID: 24900350; 162226805; 24900364
• PubChem CID: 71308573

理论计算性质

• Acid pKa: 12.436767
• 质子受体: 17
• 质子供体: 5
• LogD (pH = 5.5): 0.61862975
• LogD (pH = 7.4): 2.1053298
• Log P: 2.3159072
• 摩尔折射率: 232.2071 cm^3
• 极化性: 93.33953 Å^3
• 极化表面积: 238.67 Å^2
• 可自由旋转的化学键: 16
• 里宾斯基五规则: false

分子性质

理化性质

• 溶解度: H2O: ≤50 mg/mL
• 外观: powder

安全信息

• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 德国WGK号: 2; 3
• 危险公开号: 42/43
• 安全公开号: 22-36/37-45
• GHS危险品标识: GHS08
• GHS警示词: Danger
• GHS危险声明: H317-H334
• GHS警示性声明: P261-P280-P342 + P311
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• 保存温度: 2-8°C

产品相关信息

• 浓度: 8 mg/mL in 0.9% NaCl
• 药效: ≥800 units/mg tylosin
• 适用性: suitable for cell culture
• 杂质: endotoxin, tested
• 无菌消毒: sterile-filtered

详细说明

Sigma Aldrich - T3397

Application
Recommended for use in cell culture applications at 1 ml/L.
Biochem/physiol Actions
Inhibits bacterial protein synthesis at the level of 50S ribosome (L27 protein) binding. Antimicrobial spectrum: Gram-positive bacteria and mycoplasma.
Other Notes
Formulated to contain 8 mg/ml tylosin in 0.9% sodium chloride.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Sigma Aldrich - T6134

General description
泰乐菌素 A、B、C 和 D 酒石酸盐的混合物。
Application
Tylosin is a macrolide antibiotic commonly used in veterinary medicine. It is used to study protein synthesis at the level of the 50S ribosome, implant site abscess prevention in cattle, disposition kinetics1 and Mycoplasma gallisepticum and Mycoplasma meleagridis infections2.
Biochem/physiol Actions
Tylosin tartrate inhibits bacterial protein synthesis at the level of 50S ribosome (L27 protein) binding.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Sigma Aldrich - T6271

Application
Recommended for use in cell culture applications at 8 mg/L.
Biochem/physiol Actions
Interferes with bacterial protein synthesis by binding to the 50S subunit.Antimicrobial spectrum: Gram-positive bacteria and mycoplasma.
General description
泰乐菌素 A、B、C 和 D 酒石酸盐的混合物。
Reconstitution
Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 3 days.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information