(2R,3S,6S,7R)-3-(3-formamido-2-hydroxybenzamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate

• ChemBase编号: 132411
• 分子式: C28H40N2O9
• 平均质量: 548.6252
• 单一同位素质量: 548.27338087
• SMILES: CCCCCCC1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)c1cccc(c1O)NC=O)C)OC(=O)CC(C)C
• Canonical SMILES: CCCCCCC1C(=O)O[C@H](C)[C@@H](C(=O)O[C@H]([C@@H]1OC(=O)CC(C)C)C)NC(=O)c1cccc(c1O)NC=O
• InChI: InChI=1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1
• InChIKey: UIFFUZWRFRDZJC-RBVQMQRASA-N

名称和登记号

名称

• IUPAC标准名: (2R,3S,6S,7R)-3-(3-formamido-2-hydroxybenzamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate
• IUPAC传统名: (2R,3S,6S,7R)-3-(3-formamido-2-hydroxybenzamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate
• 别名: Antimycin A from Streptomyces sp.

登记号

• CAS号: 1397-94-0
• MDL号: MFCD01779723
• PubChem SID: 162226688; 24891355
• PubChem CID: 16218979

理论计算性质

• Acid pKa: 7.510312
• 质子受体: 6
• 质子供体: 3
• LogD (pH = 5.5): 4.9459143
• LogD (pH = 7.4): 4.7034187
• Log P: 4.950101
• 摩尔折射率: 141.8772 cm^3
• 极化性: 55.32945 Å^3
• 极化表面积: 157.33 Å^2
• 可自由旋转的化学键: 12
• 里宾斯基五规则: false

分子性质

安全信息

• RTECS编号: CD0350000
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 联合国危险货物编号: 3462
• 德国WGK号: 3
• 联合国危险货物等级: 6.1
• 联合国危险货物包装类别(PG): 2
• 危险公开号: 25
• 安全公开号: 26-36/37/39-45
• GHS危险品标识: GHS06; GHS09
• GHS警示词: Danger
• GHS危险声明: H300-H400
• GHS警示性声明: P264-P273-P301 + P310
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• RID/ADR: UN 3462 6.1/PG 2
• 保存温度: -20°C; 2-8°C

产品相关信息

• 纯度: ~90% (HPLC)
• 产品质量级别: PREMIUM

详细说明

Sigma Aldrich - A8674

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
Inhibitor of electron transfer at complex III. Induces apoptosis.
Quality
A mixture of antimycins.
Application
Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

Sigma Aldrich - 10792

Biochem/physiol Actions
Inhibitor of electron transfer at complex III. Induces apoptosis.
Other Notes
Inhibits the electron transport system1,2,3