(6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6H,6aH,7H,10H,10aH-benzo[c]isochromen-1-ol

• ChemBase编号: 132094
• 分子式: C25H38O3
• 平均质量: 386.56742
• 单一同位素质量: 386.28209508
• SMILES: CCCCCCC(C)(C)c1cc(c2c(c1)OC([C@H]1[C@H]2CC(=CC1)CO)(C)C)O
• Canonical SMILES: CCCCCCC(c1cc(O)c2c(c1)OC([C@H]1[C@H]2CC(=CC1)CO)(C)C)(C)C
• InChI: InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3/t19-,20-/m1/s1
• InChIKey: SSQJFGMEZBFMNV-WOJBJXKFSA-N

名称和登记号

名称

• IUPAC标准名: (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6H,6aH,7H,10H,10aH-benzo[c]isochromen-1-ol
• IUPAC传统名: (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6aH,7H,10H,10aH-benzo[c]isochromen-1-ol
• 别名: (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol; (6aR-trans)-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-Dibenzo[b,d]pyran-9-methanol; (-)-HU-210; HU 210; (6aR-trans-3-(1, 1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol; HU-210

登记号

• CAS号: 112830-95-2
• MDL号: MFCD01074786
• Beilstein号: 4298162
• PubChem SID: 24895815; 162226371
• PubChem CID: 9821569

理论计算性质

• Acid pKa: 9.983896
• 质子受体: 3
• 质子供体: 2
• LogD (pH = 5.5): 6.1395755
• LogD (pH = 7.4): 6.1384654
• Log P: 6.1395893
• 摩尔折射率: 116.7339 cm^3
• 极化性: 45.373898 Å^3
• 极化表面积: 49.69 Å^2
• 可自由旋转的化学键: 7
• 里宾斯基五规则: false

分子性质

理化性质

• 溶解度: Chloroform; DMSO; DMSO: soluble
• 外观: Pale Yellow Solid; solid (air sensitive)
• 熔点: 68-73°C

安全信息

• 保存条件: Controlled Substance, -20°C Freezer, Under Inert Atmosphere; desiccated
• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 毒品管制信息: USDEA Schedule I; stupéfiant; regulated under CDSA - not available from Sigma-Aldrich Canada
• 保存温度: -20°C

药理学性质

• 相关基因信息: human ... CNR1(1268), CNR2(1269)rat ... Cnr1(25248)

产品相关信息

• 运输包装: wet ice

详细说明

Sigma Aldrich - H7909

Biochem/physiol Actions
Cannabinoid receptor agonist.

Toronto Research Chemicals - H673500

A synthetic agonist analog of Δ9-Tetrahydro Cannabinol (T293200), which is the primary psychoactive component of marijuana. HU-210 is a potent central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist. It binds to neuroblastoma cell memb

参考文献

• Slipetz, D.M. et al.: Mol. Pharmacol., 48, 352 (1995)
• Bertalovitz, A.C. et al.: Drug Dev. Res., 71, 404 (1995)
• Howlett, A.C. et al.: Curr. Pharm. Des., 1, 343 (1995)