[3-(hexadecanoyloxy)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy]phosphonic acid

• ChemBase编号: 131283
• 分子式: C39H69O8P
• 平均质量: 696.934121
• 单一同位素质量: 696.4730058
• SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC
• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)COP(=O)(O)O
• InChI: InChI=1S/C39H69O8P/c1-3-5-7-9-11-13-15-17-18-19-20-22-24-26-28-30-32-34-39(41)47-37(36-46-48(42,43)44)35-45-38(40)33-31-29-27-25-23-21-16-14-12-10-8-6-4-2/h11,13,17-18,20,22,26,28,37H,3-10,12,14-16,19,21,23-25,27,29-36H2,1-2H3,(H2,42,43,44)/b13-11-,18-17-,22-20-,28-26-
• InChIKey: SPYWWYSOADUXOQ-BMPTZMRASA-N

名称和登记号

名称

• IUPAC标准名: [3-(hexadecanoyloxy)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy]phosphonic acid
• IUPAC传统名: 3-(hexadecanoyloxy)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxyphosphonic acid
• 别名: Ca2+-activated phospholipid-dependent serine-threonine kinase ζ isozyme human; PKCζ human; Protein Kinase Cζ isozyme human

登记号

• MDL号: MFCD03458228
• PubChem SID: 162225561; 24898083
• PubChem CID: 16219812
• Enzyme Commission Number: IUBMB ); 2.7.1.37 ( BRENDA

理论计算性质

• Acid pKa: 1.317406
• 质子受体: 5
• 质子供体: 2
• LogD (pH = 5.5): 9.782457
• LogD (pH = 7.4): 8.760826
• Log P: 12.210115
• 摩尔折射率: 201.4422 cm^3
• 极化性: 77.96821 Å^3
• 极化表面积: 119.36 Å^2
• 可自由旋转的化学键: 36
• 里宾斯基五规则: false

分子性质

理化性质

• 外观: buffered aqueous solution

安全信息

• 德国WGK号: 1
• 个人保护装置: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• 保存温度: -70°C

药理学性质

• 相关基因信息: human ... PRKCZ(5590)

产品相关信息

• 纯度: ≥75% (SDS-PAGE)
• 运输包装: dry ice
• 基因表达载体: expressed in baculovirus infected insect cells
• Mol. Weight: mol wt 76-80 kDa by SDS-PAGE

详细说明

Sigma Aldrich - P0194

Physical form
Solution in 20 mM HEPES, pH 7.5; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 250 mM NaCl, 0.05% Triton X-100, and 50% glycerol.
Biochem/physiol Actions
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.
Suitability
PKC ε can transfer 1100 nmole of phosphate to PKC ε substrate peptide per minute per mg of total protein at 30 °C.