N,2-dimethyl-2-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-9-amine

• ChemBase编号: 128290
• 分子式: C16H18N2
• 平均质量: 238.32752
• 单一同位素质量: 238.14699859
• SMILES: CNC1Cc2c(cccc2)N(C)c2ccccc12
• Canonical SMILES: CNC1Cc2ccccc2N(c2c1cccc2)C
• InChI: InChI=1S/C16H18N2/c1-17-14-11-12-7-3-5-9-15(12)18(2)16-10-6-4-8-13(14)16/h3-10,14,17H,11H2,1-2H3
• InChIKey: YXVZOBVWVRFPTE-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: N,2-dimethyl-2-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaen-9-amine; N,2-dimethyl-2-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3,5,7,12,14-hexaen-9-amine
• IUPAC传统名: metapramine; N,2-dimethyl-2-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3,5,7,12,14-hexaen-9-amine
• 别名: 10,11-Dihydro-N,5-dimethyl-5H-Dibenz[b,f]azepin-10-amine; 5-Methyl-10-methylamino-10,11-dihydrodibenzo[b,f]azepine; Metapramine; RP 19560; 10,11-Dihydro-5-methyl-10-5H-Dibenz[b,f]azepine; Metapramine

登记号

• CAS号: 21730-16-5
• PubChem SID: 162222598
• PubChem CID: 65700
• Chemspider ID: 59127
• 美国药典/FDA物质标识码: 303954M7YF
• 维基百科标题: Metapramine

理论计算性质

• 质子受体: 2
• 质子供体: 1
• LogD (pH = 5.5): 0.1552892
• LogD (pH = 7.4): 1.3929796
• Log P: 3.294852
• 摩尔折射率: 75.6687 cm^3
• 极化性: 29.205658 Å^3
• 极化表面积: 15.27 Å^2
• 可自由旋转的化学键: 1
• 里宾斯基五规则: true

分子性质

药理学性质

• 给药途径: Oral
• 半衰期: 7-8 hours
• 法定药品分级: Rx-only

详细说明

Toronto Research Chemicals - M225830

Metapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine.

参考文献

• Dagonneau, H. et al.: Comp. Rend. Sea. Soc. Biol. Ses Fil., 180, 53 (1986)
• Bonierbale M. et al.: L'Encéphale, 2, 219 (1986)
• Cuenca, E. et al.: Arch. Farmacol. Toxicol., 5, 154 (1986)