N-ethyl-3-phenylbicyclo[2.2.1]heptan-2-amine

• ChemBase编号: 1262
• 分子式: C15H21N
• 平均质量: 215.33394
• 单一同位素质量: 215.16739968
• SMILES: N(C1C2CC(C1c1ccccc1)CC2)CC
• Canonical SMILES: CCNC1C2CCC(C1c1ccccc1)C2
• InChI: InChI=1S/C15H21N/c1-2-16-15-13-9-8-12(10-13)14(15)11-6-4-3-5-7-11/h3-7,12-16H,2,8-10H2,1H3
• InChIKey: IKFBPFGUINLYQI-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: N-ethyl-3-phenylbicyclo[2.2.1]heptan-2-amine
• IUPAC传统名: fencamfamine
• 商标名: Glucoenergan; Reactivan; Euvitol
• 别名: Fencamfamin; Fencamfamin hydrochloride; Fencamfamine [inn-french]; Fencamfamine hydrochloride; Fencamfaminum [inn-latin]; Fencanfamina [inn-spanish]; Fencamfamina [dcit]; 2-Ethylamino-3-phenylnorcamphane hydrochloride; 2-Ethylamino-3-phenyl-norcamphane hydrochloride; 2-Aethylamino-3-phenyl-nor-camphan; Fencamfamine

登记号

• CAS号: 1209-98-9
• PubChem SID: 160964722; 46508161
• PubChem CID: 14584

理论计算性质

JChem

• 质子受体: 1
• 质子供体: 1
• LogD (pH = 5.5): -0.029843722
• LogD (pH = 7.4): 0.3056124
• Log P: 3.2056742
• 摩尔折射率: 67.6398 cm^3
• 极化性: 26.954664 Å^3
• 极化表面积: 12.03 Å^2
• 可自由旋转的化学键: 3
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: 3.46
• LOG S: -4.86
• 溶解度: 2.95e-03 g/l

分子性质

理化性质

• 疏水性(logP): 3.20 [SANGSTER (1994)]

详细说明

DrugBank - DB01463

• Drug Groups: illicit; approved; withdrawn
• Description: Fencamfamine (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases. [Wikipedia]
• Indication: For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy.
• Pharmacology: Fencamfamine increases drive and mental alertness and an elevation of mood and a general feeling of well-being. It is a central nervous system stimulant, which increases locomotor activity.
• Toxicity: Overdosage is characterised by nausea, agitation and restlessness, dryness of the mouth, dizziness and tremor. In gross overdosage the above symptoms may also be associated with dyspnoea, tachycardia, disorientation and convulsions.
• Affected Organisms: Humans and other mammals
• References: [Link] ; DeLucia R, Planeta CS: Fencamfamine. Gen Pharmacol. 1990;21(2):161-3. [Pubmed]
• External Links: Wikipedia

参考文献

• Link
• DeLucia R, Planeta CS: Fencamfamine. Gen Pharmacol. 1990;21(2):161-3. Pubmed