sodium hydrogen carbonate

• ChemBase编号: 1202
• 分子式: CHNaO3
• 平均质量: 84.00661
• 单一同位素质量: 83.98233817
• SMILES: [Na+].OC(=O)[O-]
• Canonical SMILES: [O-]C(=O)O.[Na+]
• InChI: InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
• InChIKey: UIIMBOGNXHQVGW-UHFFFAOYSA-M

名称和登记号

名称

• IUPAC标准名: sodium hydrogen carbonate
• IUPAC传统名: potassium bicarbonate; sodium bicarbonate
• 商标名: Natrum bicarbonicum; Gripe water; Hema BP-38; Colovage; Colyte; E-Z-EM Prep Lyte; Elliotts B solution; Endosol extra; Glycoprep; Go-evac; Golytely; Co-lav; Citrocarbonate; Baros; BSS plus; 800 Sodium Bicarbonate Powder; Acidosan; Neut; Nulytely; OCL; Peg-lyte; Sandoz sodium bicarbonate; Sodium bicarbonate in plastic container; Sodium bicarbonate liquid concentrate; Meylon
• 别名: 重碳酸钠; 碳酸氢钠; 碳酸氢钠 溶液; 碳酸氢钠, ACS; 碳酸氢钠; 小苏打; 碳酸氢钠, Puratronic®; Sodium bicarbonate solution; Sodium bicarbonate concentrate; Sodium bicarbonate; Sodium hydrogencarbonate; Sodium bicarbonate solution; nahcolita; sodium bicarbonata; Sodium hydrogen carbonate, ACS; Sodium hydrogen carbonate; Sodium hydrocarbonate; Sodium hydrogen carbonate; Sodium hydrogencarbonate; Sodium acid carbonate; Carbonic acid monosodium salt; Bicarbonate of soda; Sodium bicarbonate; Baking Soda; Monosodium carbonate; SODIUM BICARBONATE ACS REAGENT GRADE; SODIUM BICARBONATE, U.S.P.; SODIUM BICARBONATE, HPLC GRADE; Natrii hydrogenocarbonas; Sodium bicarbonate; Sodium hydrogen carbonate, Puratronic®

登记号

• CAS号: 144-55-8
• EC号: 231-791-2; 205-633-8
• MDL号: MFCD00003528
• Beilstein号: 4153970
• 默克索引号: 148583
• PubChem SID: 24899673; 24899815; 24899682; 24848145; 46507049; 160964664; 24899817; 24899582; 24858955; 24899739; 24865036; 24889074; 24899571; 24899695; 24862462
• PubChem CID: 516892
• CHEBI ID: 32139
• ATC码: B05XA02; QG04BQ01; B05CB04
• CHEMBL: 1353
• Chemspider ID: 8609
• DrugBank ID: DB01390
• KEGG ID: C12603
• 医学主题词(MeSH): Sodium+bicarbonate
• 美国药典/FDA物质标识码: 8MDF5V39QO
• 维基百科标题: Sodium_bicarbonate

理论计算性质

JChem

• Acid pKa: 6.0525417
• 质子受体: 3
• 质子供体: 1
• LogD (pH = 5.5): 0.142811
• LogD (pH = 7.4): -1.1138874
• Log P: 0.25005138
• 摩尔折射率: 20.3353 cm^3
• 极化性: 3.759794 Å^3
• 极化表面积: 60.36 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: -0.06
• LOG S: 0.96
• 溶解度: 7.64e+02 g/l

分子性质

理化性质

• 溶解度: 100 mg/mL at 25 oC [MERCK INDEX (1996)]; 9 g/100 mL69 g/L (0 °C) ; 96 g/L (20 °C) ; 165 g/L (60 °C); 236 g/L (100 °C) in water; H2O: soluble0.1 g/mL at 25 °C, clear, colorless; H2O: soluble0.5 g/10 mL, clear, colorless; H2O: soluble1 M at 20 °C, clear, colorless; H2O: soluble1 M, clear, colorless; insoluble in ethanol; Soluble in water. Insoluble in alcohol
• 外观: crystalline; dry powder; Granular; liquid; powder; Powder; solution (7.5%); White crystals
• 熔点: 270 °C; decomposition begins at 50 °C; 50°C (decomposes)
• 沸点: 851°C
• 密度: 2.159; 2.159 at 20 °C; 2.16 g/mL at 25 °C(lit.); 2.20 g cm^-3
• 折射率: 1.3344; 1.500
• 分配系数: -0.82
• 紫外吸收波长: λ: 240 nm Amax: ≤0.1; λ: 250 nm Amax: ≤0.04; λ: 260 nm Amax: ≤0.01; λ: 260 nm Amax: ≤0.02; λ: 280 nm Amax: ≤0.01; λ: 500 nm Amax: ≤0.01
• pKa: (1) 6.37, (2) 10.25 (carbonic acid) (25°C); 10.3296.351 (carbonic acid)
• 气味: odorless
• 标准摩尔生成焓 (ΔfH^o298): -948 kJ·mol^-1
• 标准摩尔熵 (S^o298): 102 J·mol^-1·K^-1
• pH值: ≤8.6 (20 °C, 5%); 7.5-8.5 (25 °C, 1 M in H2O, freshly prepared); 8.0-8.6 (25 °C, 50 mg/mL in H2O)

安全信息

• 保存条件: Room Temperature (15-30°C)
• RTECS编号: VZ0950000
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 1; nwg
• 危险公开号: R:36/37/38
• 安全公开号: S:20-25-26-37/39
• TSCA收录: 是
• 主要危害: Causes serious eye irritation
• NFPA704:
  

  0

  1

  0
• 半数致死量: 4.22 g kg^-
• GHS危险声明: H303
• GHS警示性声明: P312
• 个人保护装置: Eyeshields, Gloves; Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C

药理学性质

• 给药途径: Intravenous, oral

产品相关信息

• 纯度: ≥99%; ≥95%; ≥99.0%; ≥99.0% (T); ≥99.5%; ≥99.5% (T); ≥99.7%; ≥99.7% (T); 99%; 99.0-100.5%; 99.5%; 99.5-100.3%; 99.5-100.5%; 99.7-100.3%; 99.7-100.3% dry basis; 99.998% (metals basis)
• 浓度: 0.1 M NaHCO3 in H2O
• 级别: ACS; ACS reagent; ACS reagent, reag. Ph. Eur.; Biotechnology Performance Certified; for HPLC; for molecular biology; HPLC; Hybri-Max™; JIS special grade; Ph Eur; puriss.; puriss. p.a.; purum p.a.; REAGENT; ReagentPlus®; SAJ first grade; USP
• 颗粒大小: -40-+140 mesh
• 适用性: cell culture tested; complies for appearance of solution; in accordance for filter test; in accordance for RP gradient test; insect cell culture tested; meets USP testing specifications; suitable for cell culture; suitable for hybridoma; suitable for insect cell culture
• 简要说明: 7.5% solution; for research or for further manufacturing use
• 杂质: ≤0.0005% ammonium (NH4); ≤0.0005% Phosphorus (P); ≤0.002% ammonium (NH4), complies; ≤0.003% S compounds; ≤0.003% S-compounds (as SO4); ≤0.003% sulfur compounds (as SO4); ≤0.005% I red. matters (as SO2); ≤0.005% iod red. matter (as I); ≤0.005% iod red. matter (as J); ≤0.015% in water insoluble matters; ≤0.015% Insoluble matter; ≤0.015% insolubles; 2-5% Na2CO3; ammonia (NH3), in accordance; bioburden, tested; DNase, RNase, Protease, tested; endotoxin, tested; insoluble matter, passes filter test; organic volatile impurities, complies; residual solvents, complies; water-insoluble matter, complies
• 痕量阳离子: Al: ≤0.0005%; Al: ≤0.5 mg/kg; Al: ≤10 mg/kg; As: ≤0.1 mg/kg; As: ≤2 mg/kg; As: 2 ppm (MHS-AAS); Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca, Mg and R2O3 precipitate: ≤0.02%; Ca: ≤0.005%; Ca: ≤0.02%; Ca: ≤100 mg/kg; Ca: ≤100 ppm; Cd: ≤5 mg/kg; Cd: ≤5 ppm; Cd: ≤50 mg/kg; Co: ≤5 mg/kg; Co: ≤50 mg/kg; Co: ≤50 ppm; Cr: ≤5 mg/kg; Cu: ≤0.0005%; Cu: ≤5 mg/kg; Cu: ≤5 ppm; Cu: ≤50 mg/kg; Fe: ≤0.0005%; Fe: ≤0.001%; Fe: ≤10 mg/kg; Fe: ≤20 mg/kg; Fe: ≤5 mg/kg; Fe: ≤5 ppm; heavy metals (as Pb): ≤5 ppm; heavy metals: ≤5 ppm; Hg: ≤1 mg/kg; K: ≤0.005%; K: ≤100 mg/kg; K: ≤50 mg/kg; K: ≤50 ppm; Li: ≤5 mg/kg; Mg: ≤0.005%; Mg: ≤50 mg/kg; Mg: ≤50 ppm; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; NH4+: ≤0.0005%; NH4+: ≤5 mg/kg; NH4+: ≤5 ppm; Ni: ≤5 mg/kg; Ni: ≤50 mg/kg; Ni: ≤50 ppm; Pb: ≤0.0005%; Pb: ≤10 mg/kg; Pb: ≤2 mg/kg; Pb: ≤5 mg/kg; Pb: ≤5 ppm; Sr: ≤5 mg/kg; Zn: ≤0.0005%; Zn: ≤5 mg/kg; Zn: ≤5 ppm; Zn: ≤50 mg/kg
• 痕量阴离子: carbonate (CO32-): in accordance; chloride (Cl-): ≤0.003%; chloride (Cl-): ≤10 mg/kg; chloride (Cl-): ≤100 mg/kg; chloride (Cl-): ≤150 mg/kg; chloride (Cl-): ≤20 mg/kg; chloride (Cl-): ≤30 mg/kg; phosphate (PO43-): ≤0.001%; phosphate (PO43-): ≤10 mg/kg; sulfate (SO42-): ≤0.003%; sulfate (SO42-): ≤100 mg/kg; sulfate (SO42-): ≤30 mg/kg; sulfur compounds (as SO42-): ≤0.003%
• Foreign Activity: DNase, RNase and protease, none detected
• 无菌消毒: sterile-filtered
• 干燥失重: ≤0.2% loss on drying (silica gel)
• pH范围: 6.8 - 7.4; 7.8 - 8.2
• 产品质量级别: GMP; PREMIUM
• 品质说明: meets analytical specification of Ph. Eur., BP, USP, FCC, E500
• λ: 1 M in H2O; 10 % in H2O
• 药典: testing & handling conforms to Pharmacopeia
• 产品线: BioReagent; BioUltra; BioXtra
• 线性分子式: NaHCO3

详细说明

MP Biomedicals - 02194847

Molecular Biology Reagent
Purity: >99%

MP Biomedicals - 02191435

ACS Reagent Grade
Purity: 99.5%-100.0%
Crystalline powder

MP Biomedicals - 02194553

Cell Culture Reagent
Crystalline
Purity: 99.5%

MP Biomedicals - 02195497

Crystalline
Purity: 99.5%

DrugBank - DB01390

• Drug Groups: approved
• Description: Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
• Indication: Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
• Pharmacology: Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
• Affected Organisms: Humans and other mammals
• External Links: Wikipedia; RxList; Drugs.com

Sigma Aldrich - S4019

法律信息
Hybri-Max 商标 Sigma-Aldrich Co. LLC

Sigma Aldrich - S5761

Application
Sodium bicarbonate is broadly used as a physiological buffer in cell culture applications. The pKa for bicarbonate <-> carbonic acid reaction is 6.4 The pKa for bicarbonate <-> carbonate reaction is 10.3. Sodum bicarbonate has two pKas, 6.4 and 10.3. It is broadly used as an physiological buffer in in vitro applications.

Sigma Aldrich - S8761

Preparation Note
用细胞培养级水配制。

Sigma Aldrich - 71627

Other Notes
灌注液（如林格液）的重要组分1

Sigma Aldrich - 59221C

Application
Sodium bicarbonate is the most common buffer used in standard cell culture media and reagents. Additionally, most cells require carbonate ions for certain metabolic functions. Dry powder media is not typically manufactured with sodium bicarbonate because it may cause the media to clump over time. During liquid medium preparation, sodium bicarbonate can be added as a sterile solution or as a powder prior to filtration.

Sigma Aldrich - 36486

General description
该经过认证的离子色谱洗脱浓缩液可通过电势滴定检验溯源到 NIST 国家标准参考物质。符合 ISO 指南 31。精确含量、不确定度、可溯源性和有效期在证书上都有详细描述。 下载地址：http://www.sigma-aldrich.com。
Preparation Note
由碳酸氢钠和高纯水（18.2MΩ， 0.2μm 膜过滤）配制而成

Sigma Aldrich - S8875

包装
1, 2.5 kg in poly bottle
5 kg in poly drum
500 g in poly bottle
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

Sigma Aldrich - S6297

包装
1 kg in poly bottle
250 g in poly bottle

Sigma Aldrich - 401676

包装
12 kg in fiber drum
2.5 kg in poly bottle

Sigma Aldrich - S6014

包装
12, 50 kg in poly drum