lithium(1+) ion

• ChemBase编号: 1184
• 分子式: Li+
• 平均质量: 6.941
• 单一同位素质量: 7.01600455
• SMILES: [Li+]
• Canonical SMILES: [Li+]
• InChI: InChI=1S/Li/q+1
• InChIKey: HBBGRARXTFLTSG-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: lithium(1+) ion
• IUPAC传统名: LithoTab
• 商标名: LithoTab; Eskalith
• 别名: Lithium

登记号

• CAS号: 7439-93-2
• PubChem SID: 46505392; 160964646
• PubChem CID: 28486

理论计算性质

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): 0.0
• LogD (pH = 7.4): 0.0
• Log P: 0.0
• 摩尔折射率: 0.0 cm^3
• 极化性: 1.7969184 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

详细说明

DrugBank - DB01356

• Drug Groups: approved
• Description: Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.
• Indication: Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
• Pharmacology: Although lithium has been used for over 50 years in treatment of bipolar disorder, the mechanism of action is still unknown. Lithium's therapeutic action may be due to a number of effects, ranging from inhibition of enzymes such as glycogen synthase kinase 3, inositol phosphatases, or modulation of glutamate receptors.
• References: Quiroz JA, Machado-Vieira R, Zarate CA Jr, Manji HK: Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects. Neuropsychobiology. 2010;62(1):50-60. Epub 2010 May 7. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

参考文献

• Quiroz JA, Machado-Vieira R, Zarate CA Jr, Manji HK: Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects. Neuropsychobiology. 2010;62(1):50-60. Epub 2010 May 7. Pubmed