bis(dimethylsilyl)amine

• ChemBase编号: 112754
• 分子式: C4H15NSi2
• 平均质量: 133.3396
• 单一同位素质量: 133.07430255
• SMILES: C[SiH](C)N[SiH](C)C
• Canonical SMILES: C[SiH](N[SiH](C)C)C
• InChI: InChI=1S/C4H15NSi2/c1-6(2)5-7(3)4/h5-7H,1-4H3
• InChIKey: NQCZAYQXPJEPDS-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: bis(dimethylsilyl)amine
• IUPAC传统名: bis(dimethylsilyl)amine
• 别名: 1,1,3,3-四甲基二硅氮烷; 四甲基二硅氮烷; TETRAMETHYL DISILAZANE; TMDS; 1,1,3,3-Tetramethyldisilazane; Bis(dimethylsilyl)amine; Tetramethyldisilazane

登记号

• CAS号: 15933-59-2
• EC号: 240-072-2
• MDL号: MFCD00025626
• Beilstein号: 741869
• PubChem SID: 24848399; 162097892
• PubChem CID: 6327317

理论计算性质

• 质子受体: 1
• 质子供体: 1
• LogD (pH = 5.5): -4.1027784
• LogD (pH = 7.4): -3.7365577
• Log P: -0.5031
• 摩尔折射率: 38.6353 cm^3
• 极化性: 15.48848 Å^3
• 极化表面积: 12.03 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

分子性质

理化性质

• 熔点: 99-100 °C
• 沸点: 99-100°C
• 闪点: 26.6 °F; -3 °C; -3°C(26°F)
• 密度: 0.752 g/mL at 25 °C(lit.); 0.768
• 折射率: 1.4055; n20/D 1.404(lit.)

安全信息

• 保存注意事项: Moisture Sensitive
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C); 易燃性(Flammable) (F); 刺激性(Irritant) (Xi)
• 联合国危险货物编号: 2924; UN2924
• 德国WGK号: 3
• 联合国危险货物等级: 3
• 联合国危险货物包装类别(PG): 2; II
• 危险公开号: 11-34; 11-36/37/38
• 安全公开号: 16-26-36; 16-26-36/37/39-45
• TSCA收录: 是
• GHS危险品标识: GHS02; GHS05; GHS07
• GHS警示词: Danger
• GHS危险声明: H225-H314-H318; H225-H315-H319-H335
• GHS警示性声明: P210-P261-P305 + P351 + P338; P210-P280-P303+P361+P353-P305+P351+P338-P310
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 2924 3/PG 2

产品相关信息

• 纯度: ≥97.0% (GC); 95+%; 97%; 98+%
• 级别: purum
• 线性分子式: [(CH3)2SiH]2NH

详细说明

MP Biomedicals - 05225649

MP Biomedicals Rare Chemical collection

Sigma Aldrich - 139246

包装
10 g in glass bottle

Sigma Aldrich - 87830

Other Notes
硅烷化试剂1；β-羟基烯烃的硅烷化/氢化硅烷化，形成硅氧烷2,3

参考文献

• Reagent for the preparation (see Appendix 4) of dimethylsilyl (DMS) derivatives, compare Hexamethyldisilazane, A15139. With allylic and homoallylic alcohols, the products can undergo Pt- or Rh-catalyzed intramolecular hydrosilylation, providing a regioselective route to 1,3-diols: J. Am. Chem. Soc., 108, 6090 (1986). For an example of this reaction, see Chlorodimethylsilane, A13113.
• The potassium derivative, formed by reaction with KH in THF, reacts with alkyl halides to give, after hydrolysis, high yields of primary amines, thus providing a convenient alternative to the classical Gabriel method. Other silazanes, including hexamethyldisilazane, give lower yields: Synthesis, 150 (1995):