N-[2-(diethylamino)ethyl]-4-acetamidobenzamide hydrochloride

• ChemBase编号: 111887
• 分子式: C15H24ClN3O2
• 平均质量: 313.82296
• 单一同位素质量: 313.1557047
• SMILES: Cl.CCN(CC)CCNC(=O)c1ccc(NC(=O)C)cc1
• Canonical SMILES: CCN(CCNC(=O)c1ccc(cc1)NC(=O)C)CC.Cl
• InChI: InChI=1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H
• InChIKey: IYEWBJUCJHKLHD-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: N-[2-(diethylamino)ethyl]-4-acetamidobenzamide hydrochloride
• IUPAC传统名: acecainide hydrochloride; NAPA hydrochloride
• 别名: N-乙酰普卡胺 盐酸盐; 乙酰卡尼 盐酸盐; N-乙酰普鲁卡因胺 盐酸盐; N-Acetylnovocainamide hydrochloride; Acecainide hydrochloride; N-ACETYLPROCAINAMIDE HYDROCHLORIDE; NAPA; N-Acetylprocainamide hydrochloride

登记号

• CAS号: 34118-92-8
• EC号: 251-831-2
• MDL号: MFCD00012501
• PubChem SID: 24852214; 24890983; 162097191
• PubChem CID: 71417

理论计算性质

• Acid pKa: 13.733227
• 质子受体: 3
• 质子供体: 2
• LogD (pH = 5.5): -2.2039006
• LogD (pH = 7.4): -0.63056004
• Log P: 1.017533
• 摩尔折射率: 82.4124 cm^3
• 极化性: 30.613617 Å^3
• 极化表面积: 61.44 Å^2
• 可自由旋转的化学键: 7
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: H2O: soluble50 mg/mL
• 外观: powder
• 熔点: 184-186 °C(lit.); 187-192°C

安全信息

• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C; 2-8°C

产品相关信息

• 纯度: ≥99% (HPLC); 99%
• 线性分子式: 4-(CH3CONH)C6H4CONHCH2CH2N(C2H5)2·HCl

详细说明

MP Biomedicals - 05221568

MP Biomedicals Rare Chemical collection

Sigma Aldrich - A5513

Application
N-Acetylprocainamide hydrochloride is a class III antiarrhythmic compound. N-Acetylprocainamide hydrochloride has been used in a study to determine the disposition of procainamide and N-acetylprocainamide in protein-calorie malnutrition. N-Acetylprocainamide hydrochloride has also been used to study pharmacokinetics of procainamide and N-acetylprocainamide in rats.
Biochem/physiol Actions
III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。

Sigma Aldrich - A5909

Biochem/physiol Actions
III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。

Sigma Aldrich - 205656

包装
1, 5 g in glass bottle
Biochem/physiol Actions
III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。