您当前所在的位置:首页 > 产品中心 > 产品详细信息
4330-99-8 分子结构
点击图片或这里关闭

dimethyl[2-methyl-3-(10H-phenothiazin-10-yl)propyl]amine

ChemBase编号:1115
分子式:C18H22N2S
平均质量:298.44568
单一同位素质量:298.15036971
SMILES和InChIs

SMILES:
S1c2c(N(CC(CN(C)C)C)c3c1cccc3)cccc2
Canonical SMILES:
CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C
InChI:
InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
InChIKey:
ZZHLYYDVIOPZBE-UHFFFAOYSA-N

引用这个纪录

CBID:1115 http://www.chembase.cn/molecule-1115.html

Collapse All Expand All

名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
dimethyl[2-methyl-3-(10H-phenothiazin-10-yl)propyl]amine
IUPAC传统名
spansule
trimeprazine
商标名
Alimezine
Dosegran
Doxergan
Dysedon
Imakol
Levoprome
Panectyl
Repeltin
Repetin
Temaril
Teralen
Theralene
Vallergan
别名
(+-)-Alimemazine
(+-)-Trimeprazine
Alimemazine
Alimemazine S,S-dioxide
Bayer 1219
Oxomemazin
Oxomemazina [INN-Spanish]
Oxomemazine
Methylpromazine
Oxomemazine [DCF:INN]
Oxomemazinum [INN-Latin]
Oxymemazine
Trimeperazine
Trimeprazine 5,5-dioxide
Trimeprazine hemi-(+)tartrate
Trimeprazine Tartrat
Trimeprazine Tartrate
Trimeprazine
N,N,β-Trimethyl-10H-phenothiazine-10-propanamine Tartrate
10-(2-Methyl-3-dimethylaminopropyl)phenothiazine Tartrate
10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine Tartrate
(+/-)-Alimemazine Tartrate
Panectyl
Repeltin
Temaril
Temaril 16
Theralene
Vallergan
Vanectyl
NSC 17475
Trimeprazine Hemitartrate Salt
CAS号
4330-99-8
84-96-8
PubChem SID
160964578
46508449
PubChem CID
5574

数据来源

数据来源

所有数据来源 商品来源 非商品来源
数据来源 数据ID 价格
TRC
T795700 external link 加入购物车 请登录

理论计算性质

理论计算性质

JChem ALOGPS 2.1
质子受体 质子供体
LogD (pH = 5.5) 1.0487792  LogD (pH = 7.4) 2.398943 
Log P 4.4102793  摩尔折射率 93.3679 cm3
极化性 36.0012 Å3 极化表面积 6.48 Å2
可自由旋转的化学键 里宾斯基五规则 true 
Log P 4.82  LOG S -4.55 
溶解度 8.35e-03 g/l 

分子性质

分子性质

理化性质 安全信息 产品相关信息 生物活性(PubChem)
溶解度
0.942 mg/L expand 查看数据来源
Methanol expand 查看数据来源
Water expand 查看数据来源
外观
White to Off-White Solid expand 查看数据来源
熔点
153-155°C expand 查看数据来源
疏水性(logP)
4.6 expand 查看数据来源
保存条件
Refrigerator expand 查看数据来源
MSDS下载
下载链接 expand 查看数据来源
质检报告
下载链接 expand 查看数据来源

详细说明

详细说明

DrugBank DrugBank TRC TRC
DrugBank -  DB01246 external link
Item Information
Drug Groups approved
Description A phenothiazine derivative that is used as an antipruritic. [PubChem]
Indication Used to prevent and relieve allergic conditions which cause pruritus (itching) and urticaria (some allergic skin reactions).
Pharmacology Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics, but differing in the ring-substitution and chain characteristics. Trimeprazine is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, trimeprazine is not used clinically as an anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic (anti-nausea). Trimeprazine is used principally as an anti-emetic, to prevent motion sickness or as an anti-histamine in combination with other medications in cough and cold preparations. Tricyclic antihistamines are also structurally-related to the tricyclic antidepressants, explaining the antihistaminergic adverse effects of these two drug classes and also the poor tolerability profile of tricyclic H1-antihistamines.
Toxicity Symptoms of overdose clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Well absorbed in the digestive tract.
Toronto Research Chemicals -  T795700 external link
Antipruritic. Antibacterial, antimicrobial agent.

参考文献

参考文献

供应商提供 Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966)
  • Abdel-Moety, E., et al.: Eur. J. Pharm. Sci., 5, 1 (1966)
  • Basavaiah, K., et al.: Chem. Pharm. Bull., 47, 1351 (1966)
正在搜索,请耐心等待...(如果遇到网页错误或者长时间没有结果,请刷新页面[F5])

专利

专利

PubChem iconPubChem Patent Google Patent Search IconGoogle Patent

互联网资源

互联网资源

百度图标百度 google iconGoogle