dichloroplatinum diamine

• ChemBase编号: 111049
• 分子式: Cl2H6N2Pt
• 平均质量: 300.04504
• 单一同位素质量: 298.95559456
• SMILES: N.N.Cl[Pt]Cl
• Canonical SMILES: Cl[Pt]Cl.N.N
• InChI: InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
• InChIKey: LXZZYRPGZAFOLE-UHFFFAOYSA-L

名称和登记号

名称

• IUPAC标准名: dichloroplatinum diamine
• IUPAC传统名: platinum(II) chloride diamine
• 别名: 反式-二氨基二氯化铂(II); 反式-二氨二氯合铂(II); 顺-二氯二氨基铂(II); 顺式-二胺二氯铂; 顺氯氨铂; 顺铂; cis-Diammineplatinum(II) dichloride; cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; Cisplatin; cis-Diamineplatinum(II) dichloride; trans-Dichlorodiammineplatinum(II); trans-Platinum(II)diammine dichloride; PLATINUM DIAMMINO DICHLORIDE; cis-Diammineplatinum(II) dichloride

登记号

• CAS号: 15663-27-1; 14913-33-8
• EC号: 239-733-8; 238-980-9
• MDL号: MFCD00011623
• PubChem SID: 24871609; 162097060; 24898212; 24278632
• PubChem CID: 5702198

理论计算性质

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): 1.299
• LogD (pH = 7.4): 1.299
• Log P: 1.299
• 摩尔折射率: 12.2726 cm^3
• 极化性: 12.376327 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 外观: yellow crystalline
• 熔点: 270 °C(lit.); 340 °C (dec.)(lit.)

安全信息

• RTECS编号: TP2450000; TP2455000
• 欧盟危险性物质标志: 有毒(Toxic) (T); 有害性(Harmful) (Xn)
• 联合国危险货物编号: 3288
• 德国WGK号: 2; 3
• 联合国危险货物等级: 6.1
• 联合国危险货物包装类别(PG): 2
• 危险公开号: 41-42/43; 45-25-41
• 安全公开号: 23-36/37-39-45; 53-26-39-45
• GHS危险品标识: GHS05; GHS06; GHS08
• GHS警示词: Danger
• GHS危险声明: H300-H318-H350; H317-H318-H334
• GHS警示性声明: P201-P264-P280-P301 + P310-P305 + P351 + P338-P308 + P313; P261-P280-P305 + P351 + P338-P342 + P311
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves; Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• RID/ADR: UN 3288 6.1/PG 2

产品相关信息

• 纯度: ≥96.0% (Pt); ≥99.9% trace metals basis
• 线性分子式: Pt(NH3)2Cl2

详细说明

MP Biomedicals - 05217548

MP Biomedicals Rare Chemical collection

Sigma Aldrich - P4394

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
包装
1 g in glass bottle
25, 100, 250 mg in glass bottle

Sigma Aldrich - 479306

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
用于防止睾丸癌发展的高活性化学治疗药物。
Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
包装
1, 5 g in glass bottle

Sigma Aldrich - P1525

包装
1 g in glass bottle
250 mg in glass bottle

Sigma Aldrich - 33422

Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
Other Notes
Antitumor compound1; Review (chemistry and properties)2,3