methanesulfonic acid

• ChemBase编号: 107832
• 分子式: CH4O3S
• 平均质量: 96.10566
• 单一同位素质量: 95.98811499
• SMILES: CS(=O)(=O)O
• Canonical SMILES: CS(=O)(=O)O
• InChI: InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)
• InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: methanesulfonic acid
• IUPAC传统名: mesylate; methanesulfonic acid
• 别名: 甲烷磺酸 溶液; 甲基磺酸; 甲磺酸; Methanesulfonic acid solution; Methanesulfonic acid solution; Methanesulfonic acid concentrate; METHANESULFONIC ACID, 70% SOLUTION; Methylsulfonic acid; MSA; Methanesulfonic acid; Methanesulfonic acid; Mesic acid

登记号

• CAS号: 75-75-2
• EC号: 231-791-2; 200-898-6
• MDL号: MFCD00007518
• Beilstein号: 1446024
• 默克索引号: 145954
• PubChem SID: 24896907; 24850732; 24870724; 24879176; 24873902; 162095461; 24890163; 24870726
• PubChem CID: 6395
• CHEBI ID: 27376
• Chemspider ID: 6155
• 美国药典/FDA物质标识码: 12EH9M7279
• 维基百科标题: Methanesulfonic_acid

理论计算性质

• Acid pKa: -1.6106497
• 质子受体: 3
• 质子供体: 1
• LogD (pH = 5.5): -3.3367643
• LogD (pH = 7.4): -3.3367722
• Log P: -0.9603736
• 摩尔折射率: 16.5315 cm^3
• 极化性: 7.422034 Å^3
• 极化表面积: 54.37 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 外观: brown
• 熔点: 17-19 °C(lit.); 17–19 °C; 19-20°C; 20°C
• 沸点: 166-168°C/10mm; 167 °C/10 mmHg(lit.); 167 °C /10 mmHg, 122 °C/1 mmHg
• 闪点: >110°C(230°F); 156°C(312°F); 170 °C; 189 °C; 338 °F; 372.2 °F
• 密度: 1.039 g/mL at 20 °C; 1.319 g/mL at 25 °C; 1.320; 1.475-1.485 g/mL at 20 °C; 1.48 g/cm^3; 1.481; 1.481 g/mL at 25 °C(lit.)
• 折射率: 1.4150; 1.4300; n20/D 1.415; n20/D 1.416; n20/D 1.429; n20/D 1.429(lit.)
• 蒸汽压: <1 mmHg ( 20 °C); 1 mmHg ( 20 °C)
• 蒸汽密度: 3.3 (vs air)
• 紫外吸收波长: λ: 210 nm Amax: ≤0.2; λ: 220 nm Amax: ≤0.15; λ: 230 nm Amax: ≤0.10; λ: 240 nm Amax: 0.02; λ: 240-320 nm Amax: <0.4; λ: 250 nm Amax: 0.01; λ: 260 nm Amax: ≤0.05; λ: 260 nm Amax: 0.01; λ: 500 nm Amax: ≤0.05
• pKa: -1.9

安全信息

• 保存注意事项: Light Sensitive & Hygroscopic
• RTECS编号: PB1140000
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• 联合国危险货物编号: 2586; 2922; 3265; UN2586
• 德国WGK号: 1; 2; nwg
• 联合国危险货物等级: 8
• 联合国危险货物包装类别(PG): 2; 3; III
• 危险公开号: 21/22-34; 21/22-35; 34; R:34
• 安全公开号: 20-23-26-36/37/39-45-60; 26-36/37/39-45; 26-36-45; S:26-36-45
• TSCA收录: 是
• GHS危险品标识: GHS05; GHS07
• GHS警示词: Danger
• GHS危险声明: H290-H302 + H312-H314; H290-H302-H314; H290-H314; H314
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A; P280-P305 + P351 + P338-P310
• 个人保护装置: Eyeshields, Gloves; Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 2586 8/PG 3; UN 2922 8/PG 2; UN 3265 8/PG 2
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥98.0% (T); ≥99.0% (T); ≥99.5%; 70% aq. soln.; 98.0-102.0% (1 M NaOH, T); 98+%
• 浓度: ~1 M in H2O; ~50% in H2O; ~70% in H2O; 0.1 M CH3SO3H in H2O (0.1N); 4 M (with 0.2% (w/v) tryptamine); 4.0 M±0.1 M in H2O (T); 70 wt. % in H2O
• 级别: anhydrous; electronic grade; for HPCE; for ion chromatography; for protein sequence analysis; puriss.; purum; technical
• 适用性: corresponds for IR spectroscopy; corresponds to standard for RP gradient test; in accordance for filter test
• 蒸发残渣: ≤0.1%
• 杂质: <0.5% water; ≤1,000 ppm Sulfate (SO4); ≤10 ppm Iron; ≤5 ppm ethyl methansesulfonate (GC); ≤5 ppm heavy metals; ≤5 ppm methyl methanesulfonate (GC); ≤50 ppm Chloride (Cl); impurities reacting with OPA reagent, none detected(fluorescence test)
• 痕量阳离子: Al: ≤0.01 mg/kg; Ba: ≤0.01 mg/kg; Bi: ≤0.01 mg/kg; Ca: ≤0.05 mg/kg; Cd: ≤0.01 mg/kg; Co: ≤0.01 mg/kg; Cr: ≤0.01 mg/kg; Cu: ≤0.01 mg/kg; Fe: ≤0.05 mg/kg; K: ≤0.05 mg/kg; Li: ≤0.01 mg/kg; Mg: ≤0.01 mg/kg; Mn: ≤0.01 mg/kg; Mo: ≤0.01 mg/kg; Na: ≤0.10 mg/kg; Ni: ≤0.01 mg/kg; Pb: ≤0.01 mg/kg; Sr: ≤0.01 mg/kg; Zn: ≤0.01 mg/kg
• 痕量阴离子: chloride (Cl-): ≤50 ppm; sulfate (SO42-): ≤100 ppm
• 产品质量级别: GMP
• 品质说明: ampule
• λ: H2O reference; neat
• 线性分子式: CH3SO3H

详细说明

Sigma Aldrich - 516724

Legal Information
Arkema 产品

Sigma Aldrich - 516848

Legal Information
Arkema 产品

Sigma Aldrich - 64280

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.

Sigma Aldrich - M4141

Application
用于完整的蛋白质和肽水解及色氨酸回收。水解后，先稀释样品，再进行氨基酸分析。
包装
氩气下密封的安瓿瓶包装。

Sigma Aldrich - 471348

包装
1 L in glass bottle
100, 500 mL in glass bottle
18 L in poly drum
Legal Information
Arkema Inc. 制造

Sigma Aldrich - 471356

包装
100, 500 mL in poly bottle
5 L in poly drum
2 L in glass bottle
2.5 L in poly bottle
5, 25 mL in glass bottle

Sigma Aldrich - 64291

包装
ampoules 10 x 1 ml

Sigma Aldrich - 55517

General description
该经过认证的离子色谱洗脱浓缩液可通过电势滴定检验溯源到 NIST 国家标准参考物质。符合 ISO 指南 31。精确含量、不确定度、可溯源性和有效期在证书上都有详细描述。 下载地址：http://www.sigma-aldrich.com。
Preparation Note
由甲烷磺酸和高纯水（18.2MΩ，经 0.2μm 膜过滤）配制而成

参考文献

• Strong acid which has been used for the deprotection of peptides; see Appendix 6.
• Cleaves methyl ethers of phenols in the presence of the soft nucleophile methionine as a methyl acceptor. Polymethoxyaldehydes or ketones undergo selective cleavage of the methoxy group meta to the carbonyl: J. Chem. Soc., Perkin 1, 2288 (1977). Similarly, in combination with dimethyl sulfide, selective O-demethylation of mixed phosphate esters occurs: Synthesis, 451 (1983).