N-[1,2-dihydroxy-2-(prop-2-enamido)ethyl]prop-2-enamide

• ChemBase编号: 106687
• 分子式: C8H12N2O4
• 平均质量: 200.19188
• 单一同位素质量: 200.07970687
• SMILES: OC(NC(=O)C=C)C(O)NC(=O)C=C
• Canonical SMILES: C=CC(=O)NC(C(NC(=O)C=C)O)O
• InChI: InChI=1S/C8H12N2O4/c1-3-5(11)9-7(13)8(14)10-6(12)4-2/h3-4,7-8,13-14H,1-2H2,(H,9,11)(H,10,12)
• InChIKey: ZMLXKXHICXTSDM-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: N-[1,2-dihydroxy-2-(prop-2-enamido)ethyl]prop-2-enamide
• IUPAC传统名: N-[1,2-dihydroxy-2-(prop-2-enamido)ethyl]prop-2-enamide
• 别名: N,N′-二羟乙基双丙烯酰胺; N,N′-(1,2-二羟乙烯)二丙烯酰胺; N,N'-(1,2-二羟乙烯)二丙烯酰胺; N,N′-(1,2-Dihydroxyethylene)bisacrylamide; N,N'-(1,2-DIHYDROXYETHYLENE)-bis-ACRYLAMIDE; DHEBA; N,N′-Bisacryloyl-1,2-dihydroxy-1,2-ethylenediamine; N,N′-(1,2-Dihydroxyethylene)bis-acrylamide; 1,2-Bis(acrylamido)ethylene glycol; N,N'-(1,2-Dihydroxyethylene)bisacrylamide

登记号

• CAS号: 868-63-3
• EC号: 212-780-1
• MDL号: MFCD00008624
• Beilstein号: 1941875
• PubChem SID: 24857712; 162089033
• PubChem CID: 102501

理论计算性质

• 摩尔折射率: 48.1114 cm^3
• 极化性: 18.758928 Å^3
• 极化表面积: 98.66 Å^2
• 可自由旋转的化学键: 5
• 里宾斯基五规则: true
• Acid pKa: 11.464695
• 质子受体: 4
• 质子供体: 4
• LogD (pH = 5.5): -1.000612
• LogD (pH = 7.4): -1.0006455
• Log P: -1.0006113

分子性质

理化性质

• 熔点: 141-143°C; 156 °C (dec.)(lit.)
• 电导率: <60 μmho (2% solution)

安全信息

• 欧盟危险性物质标志: 有毒(Toxic) (T); 有害性(Harmful) (Xn)
• 德国WGK号: 3
• 危险公开号: 20/21/22-36/37/38; 45-46-22
• 安全公开号: 26-36; 53-36-45
• TSCA收录: 是
• GHS危险品标识: GHS07; GHS08
• GHS警示词: Warning
• GHS危险声明: H302-H312-H315-H319-H332-H335; H340-H350-H302
• GHS警示性声明: P261-P280-P305 + P351 + P338; P281-P264-P301+P312-P308+P313-P405-P501A
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥99.0% (TLC); 97%; 98%
• 级别: for electrophoresis
• 适用性: in accordance for electrophoresis test
• 痕量阳离子: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤500 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• 痕量阴离子: chloride (Cl-): ≤50 mg/kg; sulfate (SO42-): ≤50 mg/kg
• 线性分子式: [H2C=CHCONHCH(OH)-]2
• Empirical Formula (Hill Notation): C8H12N2O4

详细说明

MP Biomedicals - 04808331

Purity: 98%
Reversible cross-linker which contains a 1,2-diol structure (periodate sensitive) and two amidomethylol bonds (base cleavable). Useful in forming gradient gels where sample recovery is desired. Gels with DHEBA can be dissolved by incubation in periodic acid or sodium periodate.

Sigma Aldrich - D9538

Analysis Note
经过测试可用作交联剂，用于回收分离的生物分子。
Application
作为聚丙烯酰胺凝胶的可逆交联剂，能够生成凝胶，该凝胶于室温下在高碘酸稀释溶液 (2%) 中 1-2 小时可溶解。凝胶增溶对于从聚丙烯酰胺凝胶中回收蛋白质非常有用。

Sigma Aldrich - 294381

包装
5, 25 g in glass bottle

Sigma Aldrich - 37475

Other Notes
聚丙烯酰胺凝胶电泳交联剂，产生的凝胶可溶于稀释的高碘酸或水性碱溶液1。

参考文献

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