3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid

• ChemBase编号: 105857
• 分子式: C14H24N2O10
• 平均质量: 380.34776
• 单一同位素质量: 380.14309498
• SMILES: OC(=O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O
• Canonical SMILES: OC(=O)CN(CC(=O)O)CCOCCOCCN(CC(=O)O)CC(=O)O
• InChI: InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
• InChIKey: DEFVIWRASFVYLL-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid
• IUPAC传统名: EGTA
• 别名: 乙二醇-O,O'-双(2-氨乙基)-N,N,N',N'-四乙酸; 乙二醇二乙醚二胺四乙酸; 乙二醇双氨乙基醚四乙酸; 依他酸; 乙二醇双(2-氨基乙基醚)四乙酸; Ethylenebis(oxyethylenenitrilo)tetraacetic acid; Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid; EGTA (chemical); Ethylenebis(oxyethylenenitrilo)tetraacetic acid; ETHYLENEGLYCOL-bis-(β-AMINOETHYLETHER)-N,N'-TETRAACETIC ACID; ETHYLENE GLYCOL-bis-(β-AMINOETHYLETHER)-N,N,N',N'-TETRAACETIC ACID; EGTA; ETHYLENE GLYCOL-bis-(β-AMINO-ETHYLETHER)-N,N,N',N'-TETRAACETIC ACID; Chel™-DE; Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid; Egtazic acid; Ethylene-bis(oxyethylenenitrilo)tetraacetic acid; Glycol ether diamine tetraacetic acid

登记号

• CAS号: 67-42-5
• EC号: 200-651-2
• MDL号: MFCD00004291
• Beilstein号: 1717370
• 默克索引号: 143529
• PubChem SID: 24845592; 24894530; 24845591; 24278421; 162092617; 24894367
• PubChem CID: 6207
• CHEBI ID: 30740
• CHEMBL: 240390
• Chemspider ID: 5972
• KEGG ID: D00569
• 美国药典/FDA物质标识码: 526U7A2651
• 维基百科标题: EGTA_(chemical)

理论计算性质

• Acid pKa: 2.1556778
• 质子受体: 12
• 质子供体: 4
• LogD (pH = 5.5): -11.342245
• LogD (pH = 7.4): -14.649551
• Log P: -7.2473655
• 摩尔折射率: 84.4326 cm^3
• 极化性: 33.452957 Å^3
• 极化表面积: 174.14 Å^2
• 可自由旋转的化学键: 17
• 里宾斯基五规则: false

分子性质

理化性质

• 溶解度: 0.1 M NaOH: soluble0.1 M at 20 °C, clear, colorless; 1 M NaOH: soluble0.1 M at 20 °C, clear, colorless; H2O: soluble (increases as pH is increased)
• 熔点: ~250 °C (dec.); 241 °C (dec.)(lit.); 241°C; 241°C (Decomposes); 245-255 °C; ca 242°C dec.

安全信息

• 保存条件: Room Temperature (15-30°C)
• RTECS编号: AH3760000
• 德国WGK号: 2
• TSCA收录: 是
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品相关信息

• 纯度: ≥97%; ~98%; ≥97%; ≥97.0%; ≥98.0% (T); ≥98.5%; ≥98.5% (calc. to the dried substance); ≥99.0% (T); 97%
• 级别: for complexometry; for molecular biology
• 燃烧残渣: <0.1%; ≤0.05% (as SO4); ≤0.1% (as SO4)
• 杂质: <0.0005% Phosphorus (P); <0.1% Insoluble matter; ≤0.001% heavy metals (as Pb); DNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; RNases, none detected
• 痕量阳离子: Al: <0.0005%; Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: <0.0005%; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: <0.0005%; Cu: ≤5 mg/kg; Fe: <0.0005%; Fe: ≤10 mg/kg; Fe: ≤5 mg/kg; K: <0.005%; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: <0.0005%; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: <0.05%; Na: ≤200 mg/kg; NH4+: <0.05%; Ni: ≤5 mg/kg; Pb: <0.001%; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: <0.0005%; Zn: ≤5 mg/kg
• 痕量阴离子: sulfate (SO42-): <0.05%; sulfate (SO42-): ≤400 mg/kg; sulfate (SO42-): ≤50 mg/kg
• Foreign Activity: DNAse (exonuclease), NICKase (endonuclease), RNAse, and protease, none detected
• 干燥失重: ≤1% loss on drying, 150 °C; ≤1.0% loss on drying; ≤1.0% loss on drying, 110 °C
• 产品质量级别: ELITE; PREMIUM
• 产品线: BioUltra
• abs.: absorption0.1M/263 nm, 1 M NaOH cut-off
• 线性分子式: [-CH2OCH2CH2N(CH2CO2H)2]2

详细说明

MP Biomedicals - 02195174

(EGTA) Crystalline Purity: ~98% Chelating agent for determination of calcium in the presence of magnesium.

MP Biomedicals - 02194823

Molecular Biology Reagent
Purity: >97%

Sigma Aldrich - E3889

Application
可用于在存在镁的情况下测定钙的螯合剂。
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 234532

Application
可用于在存在镁的情况下测定钙的螯合剂。
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 34596

Application
可用于在存在镁的情况下测定钙的螯合剂。
General description
请访问 滴定中心 了解更多信息。
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 03779

Application
可用于在存在镁的情况下测定钙的螯合剂。
General description
请访问 滴定中心 了解更多信息。
Other Notes
Reagent for the determination of calcium1
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - E0396

Application
可用于在存在镁的情况下测定钙的螯合剂。
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 03777

Application
可用于在存在镁的情况下测定钙的螯合剂。
Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid can be used to study molecular biology, biochemicals, reagents and chelators. Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid has been used in a study that illustrated the response of the β-cyclodextrin-hemin complex in the induction of cucumber adventitious rooting through heme oxygenase-1-dependent mechanism and calcium signaling.
Other Notes
Buffer component in dideoxy sequencing of RNA using reverse transcriptase1.
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 03780

Application
可用于在存在镁的情况下测定钙的螯合剂。
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - E4378

Application
可用于在存在镁的情况下测定钙的螯合剂。
包装
1 kg in poly bottle
10, 25, 100, 250, 500 g in poly bottle
Physical properties
在水中的溶解性随 pH 值增加而增加
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 03778

Application
可用于在存在镁的情况下测定钙的螯合剂。
法律信息
Chel 商标 Ciba-Geigy AG

参考文献

• Schmidt, R.W. and Reilly, C.N., Anal. Chem. , 29 : 264 (1957).
• Reagent for complexometry.