(4S)-4-amino-1,2-oxazolidin-3-one

• ChemBase编号: 105470
• 分子式: C3H6N2O2
• 平均质量: 102.09194
• 单一同位素质量: 102.04292744
• SMILES: O=C1NOC[C@@H]1N
• Canonical SMILES: N[C@H]1CONC1=O
• InChI: InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1
• InChIKey: DYDCUQKUCUHJBH-REOHCLBHSA-N

名称和登记号

名称

• IUPAC标准名: (4S)-4-amino-1,2-oxazolidin-3-one
• IUPAC传统名: (+)-cycloserine
• 别名: 环丝氨酸; (S)-4-Amino-3-isoxazolidone; L-Cycloserine; L-4-Amino-3-Isoxazolidinone; L-CYCLOSERINE; (S)-4-AMinoisoxazolidin-3-one

登记号

• CAS号: 339-72-0
• EC号: 206-427-0
• MDL号: MFCD00064324
• Beilstein号: 80799
• PubChem SID: 24278296; 162092510
• PubChem CID: 449215

理论计算性质

• Acid pKa: 4.210087
• 质子受体: 3
• 质子供体: 2
• LogD (pH = 5.5): -2.4357781
• LogD (pH = 7.4): -2.4206417
• Log P: -2.4213324
• 摩尔折射率: 21.8488 cm^3
• 极化性: 9.062646 Å^3
• 极化表面积: 64.35 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: H2O: soluble50 mg/mg protein

安全信息

• 保存条件: 0°C, Desiccate
• RTECS编号: NY2976000
• 德国WGK号: 2
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C

产品相关信息

• 纯度: 97%

详细说明

MP Biomedicals - 02190316

Crystalline
Antibiotic substance.
Inhibitor of transaminases.

Sigma Aldrich - C1159

包装
10, 25, 100 mg in poly bottle
250 mg in poly tube
Biochem/physiol Actions
Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.1
L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.