5-chloro-N-(6-phenylhexyl)naphthalene-1-sulfonamide

• ChemBase编号: 105316
• 分子式: C22H24ClNO2S
• 平均质量: 401.94946
• 单一同位素质量: 401.12162769
• SMILES: Clc1cccc2c1cccc2S(=O)(=O)NCCCCCCc1ccccc1
• Canonical SMILES: Clc1cccc2c1cccc2S(=O)(=O)NCCCCCCc1ccccc1
• InChI: InChI=1S/C22H24ClNO2S/c23-21-15-8-14-20-19(21)13-9-16-22(20)27(25,26)24-17-7-2-1-4-10-18-11-5-3-6-12-18/h3,5-6,8-9,11-16,24H,1-2,4,7,10,17H2
• InChIKey: YUXMTDYHFPRPLG-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 5-chloro-N-(6-phenylhexyl)naphthalene-1-sulfonamide
• IUPAC传统名: 5-chloro-N-(6-phenylhexyl)naphthalene-1-sulfonamide
• 别名: SC-9; N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide; 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide; N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide; 5-CHLORO-N-(6-PHENYLHEXYL)-1-NAPHTHALENESULFONAMIDE

登记号

• CAS号: 102649-78-5
• MDL号: MFCD00065544
• PubChem SID: 24898364; 162092103
• PubChem CID: 124172

理论计算性质

• Acid pKa: 9.894852
• 质子受体: 2
• 质子供体: 1
• LogD (pH = 5.5): 6.1878676
• LogD (pH = 7.4): 6.186654
• Log P: 6.187883
• 摩尔折射率: 112.1392 cm^3
• 极化性: 45.56286 Å^3
• 极化表面积: 46.17 Å^2
• 可自由旋转的化学键: 8
• 里宾斯基五规则: false

分子性质

理化性质

• 溶解度: Chloroform; Ethyl Acetate
• 外观: Pale Yellow Solid
• 熔点: 82-84°C

安全信息

• 保存条件: Refrigerator
• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C

详细说明

MP Biomedicals - 02159753

(SC-9; N(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide)
Potent Protein Kinase C activator which apparently substitutes for phosphatidylserine.

Sigma Aldrich - P2803

Biochem/physiol Actions
Activates protein kinase C in a Ca2+-dependent manner

Toronto Research Chemicals - P330000

Activates protein kinase C in a Ca2+-dependent manner, via a mechanism similar to that of phosphatidylserine.

参考文献

• Nishino, H., et al.: Biochim. Biophys. Acta, 889, 236 (1986)
• Blest, A.D., et al.: J. Comp. Physiol., 170, 189 (1986)
• Yau, W.M., et al.: Am. J. Physiol., 263, G659 (1992)