methyl 2-(6-amino-3-imino-3H-xanthen-9-yl)benzoate hydrochloride

• ChemBase编号: 104590
• 分子式: C21H17ClN2O3
• 平均质量: 380.82428
• 单一同位素质量: 380.09277009
• SMILES: Cl.COC(=O)c1ccccc1c1c2ccc(=N)cc2oc2c1ccc(N)c2
• Canonical SMILES: COC(=O)c1ccccc1c1c2ccc(=N)cc2oc2c1ccc(c2)N.Cl
• InChI: InChI=1S/C21H16N2O3.ClH/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20;/h2-11,22H,23H2,1H3;1H
• InChIKey: MYFATKRONKHHQL-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: methyl 2-(6-amino-3-imino-3H-xanthen-9-yl)benzoate hydrochloride
• IUPAC传统名: methyl 2-(3-amino-6-iminoxanthen-9-yl)benzoate hydrochloride
• 别名: 2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester; Rhodamine 123; 2-[6-Amino-3-imino-3H-xanthen-9-yl]benzoic acid methyl ester; RHODAMINE 123

登记号

• CAS号: 62669-70-9
• EC号: 263-687-8
• MDL号: MFCD00012664
• Beilstein号: 6030951
• PubChem SID: 24888136; 24899403; 162093087
• PubChem CID: 9929799

理论计算性质

• 质子受体: 4
• 质子供体: 2
• LogD (pH = 5.5): 0.67261815
• LogD (pH = 7.4): 2.3732333
• Log P: 2.8461912
• 摩尔折射率: 123.3732 cm^3
• 极化性: 37.654495 Å^3
• 极化表面积: 85.4 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: ethanol: soluble20 mg/mL, clear, red

安全信息

• 保存条件: Room Temperature (15-30°C), Protect from light
• RTECS编号: ZE0883000
• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品相关信息

• 纯度: ≥85% (HPLC)
• 级别: for fluorescence
• 适用性: in accordance for fluorescence
• 杂质: ≤10% water
• 产品线: BioReagent
• 线性分子式: C21H17ClN2O3

详细说明

MP Biomedicals - 02156530

Used as a laser dye.

Sigma Aldrich - 83702

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
Fluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Functional assays for MDR proteins are better prognostic indicators in cancer therapy than levels of MDR protein expression. Rh 123 can be used in multiparameter analyses without fluorescence interference in combination with common protein labeling dyes such as PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid). Recent reports indicate Rh 123 may also be a substrate of MRP1.
Other Notes
Supravital mitochondrial-specific dye1

Sigma Aldrich - R8004

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Useful as a laser dye and to have selective cell growth effects. Mitochondrial specific fluorescent dye and substrate for P-glycoprotein.
Biochem/physiol Actions
Fluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Functional assays for MDR proteins are better prognostic indicators in cancer therapy than levels of MDR protein expression. Rh 123 can be used in multiparameter analyses without fluorescence interference in combination with common protein labeling dyes such as PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid). Recent reports indicate Rh 123 may also be a substrate of MRP1.
包装
5, 25, 100 mg in glass bottle

参考文献

• Bernal, S.D., et al., Science , 218 : 1117, (1982).