2-(2-oxopyrrolidin-1-yl)acetamide

• ChemBase编号: 104531
• 分子式: C6H10N2O2
• 平均质量: 142.1558
• 单一同位素质量: 142.07422757
• SMILES: NC(=O)CN1CCCC1=O
• Canonical SMILES: NC(=O)CN1CCCC1=O
• InChI: InChI=1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)
• InChIKey: GMZVRMREEHBGGF-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 2-(2-oxopyrrolidin-1-yl)acetamide
• IUPAC传统名: 2-oxo-1-pyrrolidineacetamide; 2-oxo-pyrrolidine acetamide
• 商标名: Breinox, Dinagen, Lucetam, Nootropil, Nootropyl, Oikamid, and many others
• 别名: 2-氧代-1-吡咯烷乙酰胺; 吡拉西坦; 吡乙酰胺; 2-(2-oxopyrrolidin-1-yl)acetamide; 2-(2-Oxopyrrolidino)acetamide; (2-Oxopyrrolidino)acetamide; Avigilen; Axonyl; Cerebroforte; Piramem; Pyracetam; UCB 6215; 2-Oxo-1-pyrrolidineacetamide; PIRACETAM; Piracetam; 2-(2-oxopyrrolidin-1-yl)acetamide

登记号

• CAS号: 7491-74-9
• EC号: 231-312-7
• MDL号: MFCD00079246
• PubChem SID: 162092750; 24860593; 24278639
• PubChem CID: 4843
• ATC码: N06BX03
• CHEMBL: 36715
• Chemspider ID: 4677
• KEGG ID: D01914
• 美国药典/FDA物质标识码: ZH516LNZ10
• 维基百科标题: Piracetam

理论计算性质

• Acid pKa: 15.934727
• 质子受体: 2
• 质子供体: 1
• LogD (pH = 5.5): -1.6848925
• LogD (pH = 7.4): -1.6848925
• Log P: -1.6848925
• 摩尔折射率: 35.0614 cm^3
• 极化性: 13.547892 Å^3
• 极化表面积: 63.4 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: DMSO; Methanol
• 外观: White Solid
• 熔点: 140-142°C

安全信息

• 保存条件: Refrigerator; Room Temperature (15-30°C)
• RTECS编号: UX9660500
• 德国WGK号: 2
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

药理学性质

• 作用靶点: Others
• 给药途径: Oral and parenteral
• 生物利用度: ~100%
• 排泄: Urinary
• 半衰期: 4–5 hr
• 法定药品分级: POM (UK)
• 相关基因信息: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)rat ... Gria1(50592); rat ... Gria1(50592)

产品相关信息

• 级别: VETRANAL™, analytical standard
• 成盐信息: Free Base
• Empirical Formula (Hill Notation): C6H10N2O2

详细说明

MP Biomedicals - 02156275

(2-Oxo-1-pyrrolidineacetamide)

Sigma Aldrich - P5295

Biochem/physiol Actions
Prototypical nootropic with mechanism of action similar to that of aniracetam and oxiracetam; modulates Na+-flux at AMPA receptors.

Sigma Aldrich - 33895

法律信息
VETRANAL 商标 Sigma-Aldrich Co. LLC

Toronto Research Chemicals - P500800

Nootropic.

参考文献

• Gobert, J., et al.: J. Pharm. Belg., 27, 281 (1972)
• Oosterveld, W.J., et al.: Arzneim.-Forsch., 30, 1947 (1972)
• Chouinard, G., et al.: Psychopharmacol. Bull., 17, 129 (1972)