sodium 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

• ChemBase编号: 103416
• 分子式: C12H11N2NaO3
• 平均质量: 254.21711
• 单一同位素质量: 254.0667365
• SMILES: [Na+].CCn1cc(C(=O)[O-])c(=O)c2c1nc(C)cc2
• Canonical SMILES: CCn1cc(C(=O)[O-])c(=O)c2c1nc(C)cc2.[Na+]
• InChI: InChI=1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
• InChIKey: ROKRAUFZFDQWLE-UHFFFAOYSA-M

名称和登记号

名称

• IUPAC标准名: sodium 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
• IUPAC传统名: sodium nalidixate; potassium 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
• 别名: 1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸 钠盐; 萘啶酸 钠盐; Nalidixic acid sodium salt; 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid sodium salt; 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid; NALIDIXIC ACID; NALIDIXIC ACID SODIUM SALT, γ-IRRADIATED

登记号

• CAS号: 3374-05-8
• EC号: 222-159-7
• MDL号: MFCD00064376
• Beilstein号: 3580062
• PubChem SID: 162090940; 24278589
• PubChem CID: 3864541

理论计算性质

• Acid pKa: 5.950253
• 质子受体: 5
• 质子供体: 0
• LogD (pH = 5.5): 1.0300463
• LogD (pH = 7.4): -0.25419375
• Log P: 1.0082526
• 摩尔折射率: 73.6616 cm^3
• 极化性: 22.908102 Å^3
• 极化表面积: 73.33 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: H2O: soluble50 mg/mL, clear, faintly yellow
• 外观: powder
• 熔点: > 280°C

安全信息

• 保存条件: 0°C; 0°C, Desiccate
• RTECS编号: QN2885500
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi); 有害性(Harmful) (Xn)
• 德国WGK号: 3
• 危险公开号: 42/43; R:40-36/37/38
• 安全公开号: 22-36/37-45; S:20-25-26-37/39
• GHS危险品标识: GHS07; GHS08
• GHS警示词: Danger
• GHS危险声明: H302-H317-H334
• GHS警示性声明: P261-P280-P342 + P311
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥95% (NT)
• 杂质: ≤7% water
• 无菌消毒: γ-irradiated
• 产品质量级别: PREMIUM
• Empirical Formula (Hill Notation): C12H11N2NaO3

详细说明

MP Biomedicals - 02151724

Sodium Salt
Crystalline

MP Biomedicals - 02194794

Molecular Biology Reagent
γ-Irradiated
Sodium Salt
DNA synthesis inhibitor.

Sigma Aldrich - N4382

Biochem/physiol Actions
Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.1
包装
1, 5, 25, 100 g in glass bottle

Sigma Aldrich - N3143

Application
Recommended for use in molecular biology applications at 15 μg/ml
Biochem/physiol Actions
Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.1
Reconstitution
Prepare stock solutions directly in the vial with sterile water (5-50 mg/ml). Stock solutions should be stored at -20 °C.

Sigma Aldrich - 70126

Biochem/physiol Actions
Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.1