tetracalcium hydroxycalciumylium triphosphate

• ChemBase编号: 102993
• 分子式: Ca5HO13P3
• 平均质量: 502.311423
• 单一同位素质量: 501.67595488
• SMILES: [Ca+2].[Ca+2].[Ca+2].[Ca+2].O[Ca+].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-]
• Canonical SMILES: [O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ca+]O.[Ca+2].[Ca+2].[Ca+2].[Ca+2]
• InChI: InChI=1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10
• InChIKey: XYJRXVWERLGGKC-UHFFFAOYSA-D

名称和登记号

名称

• IUPAC标准名: tetracalcium hydroxycalciumylium triphosphate
• IUPAC传统名: tetracalcium(2+) hydroxycalciumylium triphosphate; tetracalcium hydroxycalciumylium triphosphate
• 别名: 磷酸钙 三元; 磷酸钙 三元; 骨粉; 牛骨粉; 碱式磷酸钙; 羟磷灰石; 羟基磷灰石; Calcium phosphate hydroxide; Durapatite; Hydroxylapatite; HYDROXYLAPATITE FAST FLOW; Calcium phosphate tribasic; HAp; Tribasic calcium phosphate; Calcium hydroxyphosphate; Calcium phosphate tribasic; Hydroxyapatite; HYDROXYLAPATITE, CERAMIC; HYDROXYLAPATITE HIGH RESOLUTION; Si-HAp

登记号

• CAS号: 12167-74-7; 1306-06-05; 1306-06-5
• EC号: 215-145-7; 235-330-6
• MDL号: MFCD00010904
• PubChem SID: 24895395; 24879158; 24885371; 24892590; 24845698; 24879156; 24880760; 162090783; 24852723; 24892771; 24857195
• PubChem CID: 0

理论计算性质

• Acid pKa: 1.7961261
• 质子受体: 4
• 质子供体: 0
• LogD (pH = 5.5): -3.3916447
• LogD (pH = 7.4): -3.9718332
• Log P: -1.0201038
• 摩尔折射率: 11.2868 cm^3
• 极化性: 5.564544 Å^3
• 极化表面积: 86.25 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: false

分子性质

理化性质

• 溶解度: H2O: insoluble
• 外观: buffered aqueous suspension; dispersion; nanoparticles; nanopowder; powder; solid
• 熔点: 1100 °C(lit.)
• 密度: 1.038 g/mL at 25 °C
• pH值: 4-6

安全信息

• 保存条件: Room Temperature (15-30°C)
• RTECS编号: MY8434000
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 2; 3
• 危险公开号: 36/37/38
• 安全公开号: 26
• GHS危险品标识: GHS07
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• GHS警示性声明: P261-P305 + P351 + P338
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves; Eyeshields, Gloves; Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥90% (as Ca3(PO4)2, KT); ≥90% (calculated on glowed substance); ≥97%; ≥99.995% trace metals basis; 34.0-40.0% Ca basis; 35-40% Ca basis; 98.0-103.0%
• 浓度: 10 wt. % in H2O
• 级别: puriss.; purum p.a.; reagent grade; SAJ first grade
• 颗粒大小: <200 nm (BET)
• 适用性: insect cell culture tested; plant cell culture tested
• 杂质: ≤0.001% heavy metals (as Pb); ≤0.2% insoluble in HCl; ≤5% water (KFT); residual solvents, complies
• 痕量阳离子: As: ≤2 mg/kg; Cd: ≤1 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cu: ≤20 mg/kg; Fe: ≤400 mg/kg; Hg: ≤1 mg/kg; Ni: ≤5 mg/kg; Pb: ≤2 mg/kg; Pb: ≤5 mg/kg; Zn: ≤10 mg/kg; Zn: ≤20 mg/kg
• 痕量阴离子: chloride (Cl-): ≤1500 mg/kg; chloride (Cl-): ≤500 mg/kg; fluoride (F-): ≤50 mg/kg; sulfate (SO42-): ≤2000 mg/kg; sulfate (SO42-): ≤5000 mg/kg
• 其他组分: ≤0.025 wt. % dispersant (non-metal based); 5 wt. % silica as dopant
• 比表面积: >9.4 m2/g; BET surf. area 10-15 m2/g (typical); BET surf. area 14.3 m2/g (typical)
• 干燥失重: ≤10% loss on ignition, 800 °C; ≤8% loss on ignition, 800 °C
• 产品类型: Type I
• 品质说明: meets analytical specification of Ph. Eur., BP, FCC, E341
• 堆密度: 2-6 g/cm3
• 产品线: BioReagent
• Capacity: 0.7 mg/g, dry material binding capacity (DNA); 1.2 mg/g, dry material binding capacity (DNA); 12 mg/g, dry material binding capacity (BSA); 15 mL/g, dry material binding capacity (BSA)
• 线性分子式: [Ca5(OH)(PO4)3]x; 3Ca3(PO4)2 · Ca(OH)2
• Flow rate: >25 mL/h/cm2; 75 mL/h/cm2

详细说明

MP Biomedicals - 02159814

Ceramic Hydroxylapatite is a spherical, highly regular particle with excellent durability, reproducibility and resolution. This high capacity material has a 40 μm particle size, and the narrow particle size distribution assures high flow rates with minimal back pressure and fines. Especially useful for process purifications and large scale applications.
Average Pore Size: 700 Angstroms
Pressure limit: 3000 psi
Packing density: Approx. 0.6 g/ml
Ca/P molar ratio: 1.67 (stoichiometric)

MP Biomedicals - 02150162

Fast Flow Free-flowing powder for column chromatography. This unique form of calcium phosphate has an inorganic matrix ideal for fractionation and purification of proteins, enzymes, steroids, nucleic acids, plasmids and viruses.

MP Biomedicals - 02150163

High Resolution
Free-flowing powder for column chromatography. This material has the same applications as Hydroxylapatite (#150162) but allows for faster separations
and higher resolution.

Sigma Aldrich - 55497

Other Notes
蛋白质纯化1,2,3；从双链 RNA 中分离单链 RNA4；DNA 纯化5

Sigma Aldrich - C3161

Other Notes
Approx. Ca10(PO4)6(OH)2
Preparation Note
Precipitated to reduce trace impurities.
Application
Calcium phosphate tribasic (C3161) is plant cell culture tested (0.2 mg/ml) and is appropriate for use in plant cell culture experiments. Calcium phosphate tribasic is utilized to engineer new biomaterials for applications such as bone grafts and fillers.

Sigma Aldrich - 55496

Other Notes
DNA 纯化1；DNA 损伤分析2；双链 DNA 的稳定3

Sigma Aldrich - 693863

包装
5 g in glass bottle
Application
类似于纯 HAp 纳米粉体（目录号 677418），可将硅取代的羟基磷灰石 (Si-HAp) 纳米粉体结合到可生物降解的聚合物复合材料中或沉积在生物相容性表面上。据发现，硅离子代入一部分 HAp 晶格的磷酸化位点可增强 HAp 的生物活性。1,2
Protocols & Applications
Bone Tissue Engineering Based on Calcium Phosphate Ceramics

Sigma Aldrich - 289396

包装
25, 100 g in poly bottle

Sigma Aldrich - C5267

包装
100, 500 g in poly bottle

Sigma Aldrich - 702153

包装
25 mL in glass bottle
Protocols & Applications
Bone Tissue Engineering Based on Calcium Phosphate Ceramics

Sigma Aldrich - 677418

Application
已发现，结合到可生物降解的聚合物复合材料1中或沉积在生物相容性基底2上的羟基磷灰石纳米粉体可促进骨形成细胞（造骨细胞）的粘着和增殖。
包装
5, 10, 25 g in poly bottle
Protocols & Applications
Bone Tissue Engineering Based on Calcium Phosphate Ceramics

Sigma Aldrich - 574791

包装
5, 15 g in glass bottle
Protocols & Applications
Bone Tissue Engineering Based on Calcium Phosphate Ceramics

Sigma Aldrich - H0252

Application
用于纯化蛋白质和核酸。
包装
根据干重确定包装尺寸
Physical form
悬浮于 0.001M 磷酸盐缓冲液中，pH 为 6.8；固体含量约为 25%